Gastric Cancer: Geographic Differences in Multidisciplinary Management
Geographic variability in incidence, clinical presentation, and controversies surrounding optimal management have made gastric cancer a truly multidispliciplinary disease that is a challenge for epidemiologists, cancer biologists, oncologists, and surgeons alike. The decline in the incidence of gastric cancer with changing patterns of cardia versus non-cardia disease points to the multifactorial risks and the potential for risk intervention to reduce the mortality and morbidity from this disease. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - November 20, 2015 Category: Cancer & Oncology Authors: Shivaani Kummar Source Type: research
Title page
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - November 1, 2015 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - November 1, 2015 Category: Cancer & Oncology Source Type: research
Management of gastric cancer: East vs west
Gastric cancer is the fifth most common cancer in the world, with 952,000 new cases diagnosed in 2012.1 Although the incidence of gastric cancer is continuously decreasing, approximately 75% of cases die of the disease, representing the third leading cause of death due to cancer worldwide.1 Gastric cancer incidence shows remarkable international regional variation, with almost two-third of cases occurring in Asia. Besides, anatomical sites and pathologic features of gastric cancer show substantial geographic differences, suggesting different etiologies or associated risk factors. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 9, 2015 Category: Cancer & Oncology Authors: Sook Ryun Park Source Type: research
Management of gastric Cancer: East Vs. the west
Gastric cancer is the fifth most common cancer in the world, with 952,000 new cases diagnosed in 2012.1 Although the incidence of gastric cancer is continuously decreasing, about 75% of cases die of the disease, representing the third leading cause of cancer death worldwide.1 Of interest, gastric cancer incidence shows remarkable international regional variation, with almost two-thirds of all cases occurring in Asia. Besides, anatomic sites and pathologic features of gastric cancer show substantial geographical differences, suggesting different etiologies or associated risk factors. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 9, 2015 Category: Cancer & Oncology Authors: Sook Ryun Park Source Type: research
Systematic review of case reports on the abscopal effect
Radiation therapy is a highly effective local treatment for cancer. However, sporadic events of tumor regression in un-irradiated fields, known as abscopal effect, have been observed for decades. This abscopal effect has more recently been postulated to be a result of anti-tumor immune response induced by radiation therapy. With the advent of modern immunotherapy, the potential for immune activation by radiation therapy defines a novel role for radiation therapy in systemic disease. In this context, we have searched documented cases abscopal effect of radiation therapy in literature. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 8, 2015 Category: Cancer & Oncology Authors: Yazan Abuodeh, Puja Venkat, Sungjune Kim Source Type: research
From concept to clinic: Mathematically informed immunotherapy
Mathematical modeling has become a valuable tool in the continued effort to understand, predict and ultimately treat a wide range of cancers in recent years.1,2 By describing biological phenomena in the concise and formal language of mathematics, it is possible to elucidate key components of complex systems and ultimately develop tools capable of quantifying and predicting system behavior under given conditions. When these tools are applied as a complement to the detailed understanding of cancer biology provided by biological scientists and clinicians, new insights can be gained into the mechanisms and first-order principl...
Source: Current Problems in Cancer - October 8, 2015 Category: Cancer & Oncology Authors: Rachel Walker, Heiko Enderling Source Type: research
Systematic review of case reports on the abscopal effect
Radiation therapy is a highly effective local treatment for cancer. However, sporadic events of tumor regression in unirradiated fields, known as abscopal effect, have been observed for decades. This abscopal effect has more recently been postulated to be a result of antitumor immune response induced by radiation therapy. With the advent of modern immunotherapy, the potential for immune activation by radiation therapy defines a novel role for radiation therapy in systemic disease. In this context, we have searched documented cases abscopal effect of radiation therapy in literature. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 7, 2015 Category: Cancer & Oncology Authors: Yazan Abuodeh, Puja Venkat, Sungjune Kim Source Type: research
From concept to clinic: Mathematically informed immunotherapy
Mathematical modeling has become a valuable tool in the continued effort to understand, predict, and ultimately treat a wide range of cancers in recent years.1,2 By describing biological phenomena in the concise and formal language of mathematics, it is possible to elucidate key components of complex systems and ultimately develop tools capable of quantifying and predicting system behavior under given conditions. When these tools are applied as a complement to the detailed understanding of cancer biology provided by biological scientists and clinicians, new insights can be gained into the mechanisms and first-order princip...
Source: Current Problems in Cancer - October 7, 2015 Category: Cancer & Oncology Authors: Rachel Walker, Heiko Enderling Source Type: research
Clinical Trials Exploring the benefit of immunotherapy and radiation in Cancer treatment: A review of the past and A look into the future
Cancer immunotherapy is rapidly redefining the standard of cancer care. The role of radiation therapy in eliciting anti-tumoral immune response is also being actively investigated in combination with various immunotherapeutic agents to exploit potential synergy between the two modalities. In this review, we summarize the rationale and results of past and on-going clinical trials that combined the use of radiation therapy and immunogenic agents such as vaccines, cytokines, immune checkpoint inhibitors, co-stimulatory agonists, and myeloid activators. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 7, 2015 Category: Cancer & Oncology Authors: Arash Naghavi, Peter Johnstone, Sungjune Kim Source Type: research
The immune mechanisms of abscopal effect in radiation therapy
Radiation therapy (RT) is a cornerstone in oncologic management and is employed in various curative and palliative scenarios for local-regional control. RT is thought to locally control tumor cells by direct physical DNA damage or indirect insults from reactive oxygen species. Therapeutic effects apart from those observed at the treatment target, i.e. abscopal effect, have been observed for several decades, though the underlying mechanisms regulating this phenomenon have been unclear. Accumulating evidence now suggests that the immune system is a major determinant in regulating the abscopal effect. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 7, 2015 Category: Cancer & Oncology Authors: G. Daniel Grass, Niveditha Krishna, Sungjune Kim Source Type: research
Clinical trials exploring the benefit of immunotherapy and radiation in cancer treatment: A review of the past and a look into the future
Cancer immunotherapy is rapidly redefining the standard of cancer care. The role of radiation therapy in eliciting antitumoral immune response is also being actively investigated in combination with various immunotherapeutic agents to exploit potential synergy between the 2 modalities. In this review, we summarize the rationale and results of past and ongoing clinical trials that combined the use of radiation therapy and immunogenic agents such as vaccines, cytokines, immune checkpoint inhibitors, costimulatory agonists, and myeloid activators. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 6, 2015 Category: Cancer & Oncology Authors: Arash Olyie Naghavi, Peter A.S. Johnstone, Sungjune Kim Source Type: research
The immune mechanisms of abscopal effect in radiation therapy
Radiation therapy (RT) is a cornerstone in oncologic management and is employed in various curative and palliative scenarios for local-regional control. RT is thought to locally control tumor cells by direct physical DNA damage or indirect insults from reactive oxygen species. Therapeutic effects apart from those observed at the treatment target, that is, abscopal effect, have been observed for several decades, though the underlying mechanisms regulating this phenomenon have been unclear. Accumulating evidence now suggests that the immune system is a major determinant in regulating the abscopal effect. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - October 6, 2015 Category: Cancer & Oncology Authors: G. Daniel Grass, Niveditha Krishna, Sungjune Kim Source Type: research
Management of anorectal and intra-abdominal infections in the neutropenic cancer patient
Anorectal infection in the neutropenic cancer patient is a significant and potentially fatal complication in patients receiving systemic chemotherapy. The diagnosis is often made clinically on the basis of signs and symptoms (perianal pain, erythema, and tenderness), after surgical drainage of an abscess, or from cross-sectional imaging demonstrating perianal inflammation, fluid collection, or fistula formation. The management of these patients is not straightforward, and the literature continues to be unclear about the indications for and timing of surgical intervention. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - September 9, 2015 Category: Cancer & Oncology Authors: Patrick S. Sullivan, Courtney Moreno, Walid L. Shaib Source Type: research
Anorectal and Abdominal Infections in the Neutropenic Cancer Patient
Anorectal infection in the neutropenic cancer patient is a significant and potentially fatal complication in patients receiving systemic chemotherapy. The diagnosis is often made clinically on the basis on signs and symptoms (perianal pain, erythema, and tenderness), after surgical drainage of an abscess, or from cross sectional imaging demonstrating perianal inflammation, fluid collection, or fistula formation. The management of these patients is not straightforward, and the literature continues to be unclear about the indications for and timing of surgical intervention. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - September 9, 2015 Category: Cancer & Oncology Authors: Patrick S. Sullivan, Courtney Moreno, Walid Shaib Source Type: research
