Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - September 1, 2017 Category: Cancer & Oncology Source Type: research
Risk factors of Lung Cancer in nonsmoker
Generally, the cause of lung cancer is attributed to tobacco smoking. But many of the new lung cancer cases have been reported in nonsmokers. Apart from smoking; air pollution, environmental exposure, mutations, and single-nucleotide polymorphisms are known to be associated with lung cancer. Improper diet, alcohol consumption, marijuana smoking, estrogen, infections with human papillomavirus (HPV), HIV, and Epstein-Barr virus are suggested to be linked with lung cancer but clear evidences to ascertain their relation is not available. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 28, 2017 Category: Cancer & Oncology Authors: Nahid Akhtar, Jeena Gupta Bansal Source Type: research
Risk factors of Lung Cancer in Non-smoker
Generally, the cause of lung cancer is attributed to tobacco smoking. But many of the new lung cancer cases have been reported in non-smokers. Apart from smoking; air pollution, environmental exposure, mutations and single nucleotide polymorphisms are known to be associated with lung cancer. Improper diet, alcohol consumption, marijuana smoking, estrogen, infections with HPV (human papillomavirus), HIV and Epstein-Barr virus are suggested to be linked with lung cancer but clear evidences to ascertain their relation is not available. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 28, 2017 Category: Cancer & Oncology Authors: Nahid Akhtar, Jeena Gupta Bansal Source Type: research
Rituximab desensitization in three patients with severe rituximab allergy
Rituximab is a chimeric monoclonal antibody that targets CD20 positive B cells and has a positive effect on both overall and progression-free survival in B cell lymphoid malignancies. Combination rituximab with chemotherapy treatment provide survival improvement. Although rituximab is an important treatment option in hematological malignancies, the risk of allergic reactions is high. These reactions are usually IgE-mediated and can be varied in regards of severity from urticaria to anaphylaxis. It is an option to interrupt the treatment and ommit rituximab therapy who had allergic reactions. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 28, 2017 Category: Cancer & Oncology Authors: Erman Öztürk, Leyla Pur Özyiğit, Ayşe Bilge Öztürk, Meltem Olga Akay, Mustafa Çetiner, Burhan Ferhanoğlu Source Type: research
The necessity of intrathecal chemotherapy for the treatment of breast cancer patients with leptomeningeal metastasis: A systematic review and pooled analysis
Leptomeningeal carcinomatosis is a devastating disease. Despite its numerous complications, intrathecal (IT) chemotherapy remains a longstanding treatment for leptomeningeal carcinomatosis. Using case studies with internationally reported results, we attempted to determine the necessity of IT chemotherapy in treating leptomeningeal carcinomatosis. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 12, 2017 Category: Cancer & Oncology Authors: Yen-Chien Lee, Chung-Cheng Hsieh, Jen-Pin Chuang, Chung-Yi Li Source Type: research
Title Page
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 1, 2017 Category: Cancer & Oncology Source Type: research
Information for Readers
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 1, 2017 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 1, 2017 Category: Cancer & Oncology Source Type: research
Relevance of DNA damage repair in the management of prostate cancer
Recent insights into the genomic aberrations that underlie and drive prostate cancer have redoubled efforts to molecularly stratify treatments based on predictive markers. Approximately 23% of patients with metastatic castration-resistant prostate cancer exhibit somatic and/or germline aberrations in genes implicated in DNA repair, such as BRCA2, BRCA1, ATM, CHEK2 and PALB2, as well as mismatch repair (MMR) genes. At least 10% of men with advanced disease have germline mutations in DNA repair genes (DRG). (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - June 26, 2017 Category: Cancer & Oncology Authors: Patricia Banks, Wen Xu, Declan Murphy, Paul James, Shahneen Sandhu Source Type: research
Targeting ATR in cancer medicine
Deoxyribonucleic acid (DNA) damage occurs continually through various intrinsic and extrinsic mechanisms such as ultraviolet radiation, smoking, reactive oxygen species and errors during replication. The cellular DNA damage response (DDR) comprises of signaling networks that regulate a spectrum of processes, including cell-cycle progression, which enable DNA repair to occur. Ataxia telangiectasia mutated (ATM) and ataxia telangiectasia mutated and rad3-related (ATR) kinase are two key regulators of the DDR cell cycle checkpoints. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 16, 2017 Category: Cancer & Oncology Authors: Raghav Sundar, Jessica Brown, Alvaro Ingles Russo, Timothy A. Yap Source Type: research
Direct Medical Cost Associated with Colorectal Cancer in North of Jordan
Colorectal cancer (CRC) is mainly characterized as the malignant and impaired growth of rectal cells in the intestinal region. Direct medical cost is related to resources, which are directly used in treating the patient that mainly includes the cost of drugs, diagnostic, treatment, follow up, rehabilitation and hospital admission. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 15, 2017 Category: Cancer & Oncology Authors: Qais Alefan, Rana Malhees, Nizar Mhaidat Source Type: research
Information for Readers
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 1, 2017 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 1, 2017 Category: Cancer & Oncology Source Type: research
Title Page
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 1, 2017 Category: Cancer & Oncology Source Type: research
Considerations of developing an NGS assay for clinical applications in precision oncology: The NCI-MATCH NGS assay experience
Next generation sequencing (NGS) technologies have been widely adapted in clinical oncology by utilizing the profiled genetic mutation information to select patients and to guide the choice of target therapy. To fulfill the regulatory compliance, development of an NGS assay that will be used in clinical trials requires an analytical validation to meet its intend clinical use. NCI-MATCH trial is the largest precision oncology basket trial which uses a single NGS assay (NCI-MATHC NGS assay) to screen the actionable mutations in 6000 patients, who have relapsed/refractory solid tumors and lymphomas after standard systemic tre...
Source: Current Problems in Cancer - May 1, 2017 Category: Cancer & Oncology Authors: Chih-Jian Lih, Naoko Takebe Source Type: research
