The Two Faces of Protein Flexibility: A Topological Approach
Conclusion: This stems from the large amount of observations pointing to natively unfolded tracts of protein sequences as responsible for protein-protein interactions. Given the interaction with other macromolecules is the core of protein physiological role, in a local (orthosteric) paradigm of pharmacological action, we maximize the probability of perturbing the system by an agent binding in the same place where such interaction takes place: the most flexible parts of the structure. In the case of an allosteric (non-local) paradigm, the focus shifts toward the signal transmission across the protein molecule: this renders ...
Source: Current Chemical Biology - July 16, 2018 Category: Biochemistry Source Type: research
Protein Flexibility: A Challenging Issue of Drug Discovery
Conclusion: Protein flexibility stands out to be one of the most important and challenging issues for binding and discovering the potent drugs. Proteins may possess several conformations, but to study the nature of the binding site in them, one must consider its binding partner. Thus, only that conformation of protein is involved in the binding in which the structure of binding site is complementary to that of ligand. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 16, 2018 Category: Biochemistry Source Type: research
Protein Flexibility and Drug Design
(Source: Current Chemical Biology)
Source: Current Chemical Biology - July 16, 2018 Category: Biochemistry Source Type: research
Meet Our Editorial Board Member
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Source: Current Chemical Biology - July 16, 2018 Category: Biochemistry Source Type: research
Acknowledgements to Reviewers
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Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Dose-Response Effects of the CM11 as a Short Cationic Antimicrobial Peptide on Histopathological and Biochemical Changes in Mice
Conclusion: Our findings showed that although in comparison with the control group, markers level is normal but damages were visible in the tissues, as increase in the level of tissue damages has not led to increased levels of markers. It seems that the lack of correlation between tissue damage and level of liver markers probably is related to the level of damage. (Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Design, Network Analysis, In silico Modeling and Synthesis of Biologically Active Thiazolo Quinazoline Scaffolds as Anti-tubercular Agent
Conclusion: The highest inhibition observed with the synthesized compound was 6,7,8,9-tetrahydro- 5H-5-(2'-hydroxyphenyl)-2-(4'-fluorobenzylidene) thiazolo[2,3-b]quinazolin-3-phenylhydrazone 5f. (Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Synthesis, Antioxidant and Anti-inflammatoy Effects of Antioxidant Acid Amides with GABA and N-Acyl-pyrrolidin-2-ones
Conclusion: Since inflammation and oxidative stress are common characteristics of degenerative disorders, agents combining anti-inflammatory, antioxidant and cytoprotective properties could be proven useful for their treatment. (Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Dietary Compounds, Epigenetic Modifications and Metabolic Diseases
Conclusion: In this review we will focus on how dietary components which are widely present in daily dietary, acting on epigenetic mechanisms, may exhibit various effects on metabolic diseases. (Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Peptides from the Genus Jatropha: Beyond Isolation
Conclusion: Even though structural elucidation, interaction mechanisms, biosynthesis and posttranslational modifications remain challenges that need to be overcome, there is little doubt that novel peptide findings will elucidate these questions and that their synthetic analogues will represent a promising future for developing therapeutic drugs. (Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Molecular Evolution of Diverse Enzymatic Activity in Biomolecules
Conclusion: In this article, we have tried to bring all innovative works together which would be beneficial in the field of enzyme engineering, industry as well as therapeutics. (Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Fe-S Proteins Acting as Redox Switch: New Key Actors of Cellular Adaptive Responses
Conclusion: This sensing mechanism efficiently helps cells to turn on survival pathways quickly and recover from stressful conditions. (Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Meet Our Editorial Board Member
(Source: Current Chemical Biology)
Source: Current Chemical Biology - September 12, 2017 Category: Biochemistry Source Type: research
Crystallization and Preliminary X-ray Diffraction Analysis of CsaA from P. torridus: A Chaperone Rarely Found in Archaea
Conclusion: Crystallization trials with purified PtCsaA protein resulted in crystals suitable for Xray diffraction analysis. The crystals belonged to the orthorhombic space group P212121 and diffracted to the resolution limit of about 1.70 Å. Structure solution is expected to proceed using molecular replacement methods. The comparison of the resulting model structure to its counterparts from bacteria is expected to throw light on the structural similarities and differences between the homologs found in the two prokaryotic domains. (Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
Alzheimer´s Disease-associated Aβ42 Peptide: Expression and Purification for NMR Structural Studies
Conclusion: This approach, which does not require the use of costly and time-consuming reversed phase high performance liquid chromatography (RP-HPLC), offers a much straightforward strategy to those previously described to obtain [U-15N] Aβ42 and it is the first protocol through which to achieve [U-2H,13C,15N] Aβ42. The peptides obtained are of high purity and have the required isotope enrichment to support NMR-based structural studies. (Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
