Dual Opposed Survival-supporting and Death-promoting Roles of Autophagy in Cancer Cells: A Concise Review
Autophagy is a well-maintained process by which the cells recycle intracellular materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions, the induction of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy including allowing cell survival or promoting cell death could have a troublesome impact on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of autophagy in cancer is a vital need for its optimal manipulation in therapy. (Source: Current Chemical Biology)
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
Preface
(Source: Current Chemical Biology)
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
Meet Our Editorial Board Member
(Source: Current Chemical Biology)
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
POCl3 Mediated Syntheses, Pharmacological Evaluation and Molecular Docking Studies of Some Novel Benzofused Thiazole Derivatives as a Potential Antioxidant and Anti-inflammatory Agents
Conclusion: New anti-inflammatory and antioxidant agents were needed; it has been proved that benzofused thiazole derivatives were 3c, 3d and 3e constituted as an interesting template for the evaluation of new anti-inflammatory agents and an antioxidant’s work also may provide an interesting template for further development. (Source: Current Chemical Biology)
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
Distinct DNA Metabolism and Anti-proliferative Effects of Goat Urine Metabolites: An Explanation for Xeno-tumor Heterogeneity
Conclusion: This study signifies the clear differences in DNA metabolizing effects of goat UDF over other selected animal sources. Furthermore, the observed DNA metabolizing effects of goat UDF well correlate with anti-proliferative effects upon HCT-116 and MCF-7 cells. This study is a first report to show the comparison of urine metabolites among various animals. Interestingly, findings propose an indirect link that may support the possible reasons behind xeno-tumor heterogeneity in the form of rare occurrences of colorectal and mammary cancer in goat over other ruminants, non-ruminants and human. (Source: Current Chemical Biology)
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
Cytotoxicity Evaluation of Dimethoxy and Trimethoxy Indanonic Spiroisoxazolines Against Cancerous Liver Cells
Conclusion: In vitro biological evaluations revealed that dimethoxy and trimethoxy indanonic spiroisoxazoline compounds are good candidates for the development of new anti-liver cancer agents. (Source: Current Chemical Biology)
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders
In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm, endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary and essential for cell viability, signal transduction, cell-cycle control as well as transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious dis...
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
Exploration of Ion Channels in Mycobacterium tuberculosis: Implication on Drug Discovery and Potent Drug Targets Against Tuberculosis
Scientific interest in mycobacteria has been sparked by the medical importance of Mycobacterium tuberculosis (Mtb) that is known to cause severe diseases in mammals, i.e. tuberculosis and by properties that distinguish them from other microorganisms which are notoriously difficult to treat. The treatment of their infections is difficult because mycobacteria fortify themselves with a thick impermeable cell envelope. Channel and transporter proteins are among the crucial adaptations of Mycobacterium that facilitate their strength to combat against host immune system and anti-tuberculosis drugs. In previous studies, it was in...
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
Dual Opposed Survival-supporting and Death-promoting Roles of Autophagy in Cancer Cells: A Concise Review
Autophagy is a well-maintained process by which the cells recycle intracellular materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions, the induction of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy including allowing cell survival or promoting cell death could have a troublesome impact on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of autophagy in cancer is a vital need for its optimal manipulation in therapy. (Source: Current Chemical Biology)
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
Preface
(Source: Current Chemical Biology)
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
Meet Our Editorial Board Member
(Source: Current Chemical Biology)
Source: Current Chemical Biology - May 27, 2020 Category: Biochemistry Source Type: research
Acknowledgements to Reviewers
(Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
Specific Enzymatic Activity of Ceruloplasmin as a Potential Indicator of Copper Status
Conclusion: The study revealed that clinical group was significantly different in specific enzymatic activity of Cp as compared to control group. Besides this, the specific enzymatic activity of Cp was moderately but significantly correlated with serum Cu level in control group but did not reveal conclusive evidence in clinical population. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
Investigating Structural Requirements of Some Pyrimidine-linked Benzimidazole Derivatives as Anticancer Agents Against MCF-7 Cancerous Cell Line Through the use of 2D and 3D QSARs
Conclusion: These 2D and 3D models were found to give dependable indications which helped to optimize the pyrimidine-benzimidazole derivatives of the data set. The data yielded by 2D- QSAR and 3D-QSAR models will aid in giving better perceptions about structural requirements for developing newer anticancer agents. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
Green Synthesis of Silver Nanostructures Using Aqueous Extract of Dracocephalum kotschyi and Evaluation of Antioxidant Properties of Herbal Extracts and Antibacterial Feature of Green- Synthesized Nanostructures
Conclusion: According to the results of the present study, Dracocephalum kotschyi can be a suitable compound for the synthesis of nanostructures due to its indigenous cultivation and great medicinal properties. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
