Meet Our Editorial Board Member
(Source: Current Chemical Biology)
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Preface
(Source: Current Chemical Biology)
Source: Current Chemical Biology - April 7, 2021 Category: Biochemistry Source Type: research
Acknowledgements to Reviewers
(Source: Current Chemical Biology)
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
Dose Formulation, Biodistribution and PET Imaging Studies of a First-in-Class Fluorine-18 Organophosphorus Cholinesterase Inhibitor Tracer in Rat
Conclusion: Imaging and biodistribution data were highly correlated with expected radioactivity tissue uptake and distribution in target organs. Lower brain radioactivity levels by PET imaging were found for the new formulation (saline, 1% L-ascorbic acid, (Source: Current Chemical Biology)
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
Docking Simulations Exhibit Bortezomib and other Boron-containing Peptidomimetics as Potential Inhibitors of SARS-CoV-2 Main Protease
Conclusion: Interactions and the affinity of boron-containing peptidomimetics strongly suggest that boron-moieties increase affinity on the main protease, which is tested by in vitro assays. A Bis-boron-containing compound previously tested active on SARS-virus protease and bortezomib were identified as potent ligands. These advances may be relevant to drug designing, in addition to testing available boron-containing drugs in patients with COVID19 infection. (Source: Current Chemical Biology)
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
Differential Metabolites Markers from Trunking and Stressed Non-Trunking Sago Palm (Metroxylon sagu Rottb.)
Conclusion: Two sets of metabolite markers were expressed in the trunking and nontrunking sago palms. These metabolites can potentially be used as markers for identifying normal and stressed plants. (Source: Current Chemical Biology)
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
Comparative Study on Polyphenols Content and Antioxid ant Activity of Three Sweet Peppers Varieties (Capsicum annuum L.)
Conclusion: In conclusion, these findings can be regarded as very promising and justify further study, including the identification of antioxidant components in pepper extracts. Our work constitutes a first step in the study of fresh and dry sweet pepper as a promising source of natural antioxidants. (Source: Current Chemical Biology)
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
DFT Study and Synthesis of Novel Bioactive Bispyrazole using Mg/Al-LDH as a Solid Base Catalyst
Conclusion: In summary, the pharmacologically interesting bis-pyrazole derivatives were synthesized through Mg/Al-LDH as a solid base catalyst, in THF as a solvent. The synthesized bioactive compounds containing the pyrazole ring may have important biological activities and thus can serve as good candidates for pharmaceutical applications. Therefore, the catalyst Mg/Al-LDH showed high catalytic activity. Besides, a series of bispyrazole molecules were synthesized with a good yield and easy separation of the catalyst by simple filtration. Moreover, DFT calculations and reactivity indexes were used to explain the selectivity...
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
Peaceful Existence of Tumor Cells with Their Non-malignant Neighbors: The Trade of Tumor Cells with Tumor Microenvironment
Tumor cell growth and survival are the outcomes of communication between tumor cells and tumor microenvironment (TME). In other words, tumor cell growth and survival are greatly affected by the interaction between adjacent cells and tumor cells. In this paper, we review the recent advances in studies of TME, including metabolic interplays between tumor cells and their non-malignant neighbors (peaceful interaction and autophagy), trades of signaling pathways (approach to most important ones; cytokine pathway, NF-kB pathway, intra-tumoral hypoxia, oxidative stress, and nitric oxide-depended pathways), miRNAs (as the regulato...
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
Meet Our Associate Editor
(Source: Current Chemical Biology)
Source: Current Chemical Biology - January 18, 2021 Category: Biochemistry Source Type: research
Effect of Ionic Strength on the Aggregation Propensity of Aβ1-42 Peptide: An In-silico Study
Conclusion: Our findings from this computational study highlight the marked effect of ionic strength of the solution on the conformational dynamics and aggregation propensity of Aβ1-42 peptide monomer. (Source: Current Chemical Biology)
Source: Current Chemical Biology - December 28, 2020 Category: Biochemistry Source Type: research
Iron-Sulfur-Nitrosyl Complex Increases the Resistance of Pea Seedling to Water Deficiency
Conclusion: It can be assumed that the protective effect of TNIC-thio is due to the preservation of the functional state of the mitochondria. (Source: Current Chemical Biology)
Source: Current Chemical Biology - December 28, 2020 Category: Biochemistry Source Type: research
Evaluation of Snake Venom’s PhospholipaseA2 Enzyme Inhibition Activity of Cyphostemma adenocoule
Conclusion: In this study, the chloroform and ethanol extracts of the plant inhibited the enzyme of interest and thus proved the efficacy of anti-snake venom activity of the plant. (Source: Current Chemical Biology)
Source: Current Chemical Biology - December 28, 2020 Category: Biochemistry Source Type: research
Safety Evaluation of Eucalyptus globulus Essential Oils through Acute and Sub-acute Toxicity and Skin Irritation in Mice and Rats
Conclusion: This toxicity study demonstrated that Eucalyptus globulus essential oil is nontoxic at a relatively lower concentration. (Source: Current Chemical Biology)
Source: Current Chemical Biology - December 28, 2020 Category: Biochemistry Source Type: research
Insight on Ameliorative Role of Selenium Nanoparticles and Niacin in Wound Healing on Adult Female Albino Mice
Conclusion: Se NPs and niacin play an important role in accelerating and reducing the time of wound healing while they were antagonistic to each other. (Source: Current Chemical Biology)
Source: Current Chemical Biology - December 28, 2020 Category: Biochemistry Source Type: research
