Hsp90 as Drug Target Against Bacterial and Fungal Infections
Heat shock proteins (Hsps) are a group of proteins that serve to improve cell survival in response to a variety of environmental stresses of the host. In recent years, Hsps gained interest in cancer therapy and as drug target against microbial infections. The antimicrobial resistance especially by Gram-negative pathogens poses a threat to mankind. The pathogen proteins of Hsp family yield Hsp90 inhibitor antibiotic reveal mechanisms that interact with the ADP/ATP-sites of Hsp90. For the present review, we used the databases and websites PubMed, SciFinder, Scopus, ProQuest, Google and Google Scholar. The review discusses th...
Source: Current Chemical Biology - December 28, 2020 Category: Biochemistry Source Type: research
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(Source: Current Chemical Biology)
Source: Current Chemical Biology - December 28, 2020 Category: Biochemistry Source Type: research
Evaluation of Prophylactic and Therapeutic Roles of N-Acetylcysteine on Biochemical and Oxidative Changes Induced by Acute Poisoning of Diazinon in Various Rat Tissues
Background: Exposure to diazinon (DZN) as an organophosphorus insecticide is associated with reducing the antioxidant capacity of cells. N-acetyl cysteine (NAC) is widely used in clinics to treat several diseases related to oxidative stress. Objective: The current study was aimed to evaluate the prophylactic and therapeutic roles of NAC on biochemical and oxidative changes induced by acute poisoning of DZN in various tissues of male Wistar rats. Methods: Thirty rats were divided into five groups: control group received corn oil as DZN solvent; DZN group received 100 mg/kg of DZN; NAC group received 160 mg/kg of NAC; NAC-DZ...
Source: Current Chemical Biology - November 26, 2020 Category: Biochemistry Source Type: research
Nigella sativa Seed Protects Against Cadmium-induced Renal Toxicity in Rats
Background: Prevalence of chemical-induced renal injuries has been on a fast rise over the years and has become the leading cause of mortality and morbidity in the society, with environmental pollutants, heavy metals inclusive, seen as the causal agents. Recently, the role of medicinal foods in human health has gained considerable attention. Objective: We investigated the protective effects of methanolic extract of Nigella sativa (MENS) (Black seed) against cadmium-induced renal toxicity in albino rats. Methods: Twenty-five (25) male albino rats, weighing (150-170g), were randomly grouped into five groups: A-E. Group B (Ne...
Source: Current Chemical Biology - November 19, 2020 Category: Biochemistry Source Type: research
Bioremediation of Simulated Textile Effluent by an Efficient Bio-catalyst Purified from a Novel Pseudomonas fluorescence LiP-RL5
Conclusion: High catalytic efficiency of purified LiP from P. fluorescens LiP-RL5 suggests its utility as a potential candidate for biodegradation of toxic dyes in the industrial effluent, which could be successfully utilized for wastewater treatment at commercial level. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 19, 2020 Category: Biochemistry Source Type: research
In Silico Investigation of Luminol, Its Analogues and Mechanism of Chemiluminescence for Blood Identification Beyond Forensics
Conclusion: This study provides novel insight on the luminol and its expanded mechanism for broader possible applications with careful development of new methodologies. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 19, 2020 Category: Biochemistry Source Type: research
Evaluation of Prophylactic and Therapeutic Roles of NAcetylcysteine on Biochemical and Oxidative Changes Induced by Acute Poisoning of Diazinon in Various Rat Tissues
Background: Exposure to diazinon (DZN) as an organophosphorus insecticide is associated with reducing the antioxidant capacity of cells. N-acetyl cysteine (NAC) is widely used in clinics to treat several diseases related to oxidative stress. Objective: The current study was aimed to evaluate the prophylactic and therapeutic roles of NAC on biochemical and oxidative changes induced by acute poisoning of DZN in various tissues of male Wistar rats. Methods: Thirty rats were divided into five groups: control group received corn oil as DZN solvent; DZN group received 100 mg/kg of DZN; NAC group received 160 mg/kg of NAC; NAC-DZ...
Source: Current Chemical Biology - November 19, 2020 Category: Biochemistry Source Type: research
Analysis of Ion and pH Effects on Iron Response Element (IRE) and mRNA-Iron Regulatory Protein (IRP1) Interactions
Conclusion: The results obtained from this study clearly indicate that IRE RNA/IRP complex is destabilized by the change in pH and ionic strength. These observations suggest that both pH and ion are important for the assembly and stability of the IRE RNA/IRP complex formation. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 19, 2020 Category: Biochemistry Source Type: research
A Recent Review on Drug Modification Using 1,2,3-triazole
Motivated by evidence garnered from literature probing the use of triazoles in drug discovery and development, we reported the utilization of bioisosteric replacement and molecular hybridization in this review. Bio-isosteric replacement has played a significant role in modulating rapid and versatile strategy in synthesizing molecules with multifaceted medicinal properties. Molecular hybridization seeks to conjugate two molecular fragments with diverse applications under very mild reaction conditions. In this regard, 1,2,3-triazole is a well-known scaffold with widespread occurrence in medicinal compounds. It is characteriz...
Source: Current Chemical Biology - November 19, 2020 Category: Biochemistry Source Type: research
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(Source: Current Chemical Biology)
Source: Current Chemical Biology - November 19, 2020 Category: Biochemistry Source Type: research
POCl3 Mediated Syntheses, Pharmacological Evaluation and Molecular Docking Studies of Some Novel Benzofused Thiazole Derivatives as a Potential Antioxidant and Anti-inflammatory Agents
Conclusion: New anti-inflammatory and antioxidant agents were needed; it has been proved that benzofused thiazole derivatives were 3c, 3d and 3e constituted as an interesting template for the evaluation of new anti-inflammatory agents and an antioxidant’s work also may provide an interesting template for further development. (Source: Current Chemical Biology)
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
Distinct DNA Metabolism and Anti-proliferative Effects of Goat Urine Metabolites: An Explanation for Xeno-tumor Heterogeneity
Conclusion: This study signifies the clear differences in DNA metabolizing effects of goat UDF over other selected animal sources. Furthermore, the observed DNA metabolizing effects of goat UDF well correlate with anti-proliferative effects upon HCT-116 and MCF-7 cells. This study is a first report to show the comparison of urine metabolites among various animals. Interestingly, findings propose an indirect link that may support the possible reasons behind xeno-tumor heterogeneity in the form of rare occurrences of colorectal and mammary cancer in goat over other ruminants, non-ruminants and human. (Source: Current Chemical Biology)
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
Cytotoxicity Evaluation of Dimethoxy and Trimethoxy Indanonic Spiroisoxazolines Against Cancerous Liver Cells
Conclusion: In vitro biological evaluations revealed that dimethoxy and trimethoxy indanonic spiroisoxazoline compounds are good candidates for the development of new anti-liver cancer agents. (Source: Current Chemical Biology)
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders
In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm, endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary and essential for cell viability, signal transduction, cell-cycle control as well as transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious dis...
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
Exploration of Ion Channels in Mycobacterium tuberculosis: Implication on Drug Discovery and Potent Drug Targets Against Tuberculosis
Scientific interest in mycobacteria has been sparked by the medical importance of Mycobacterium tuberculosis (Mtb) that is known to cause severe diseases in mammals, i.e. tuberculosis and by properties that distinguish them from other microorganisms which are notoriously difficult to treat. The treatment of their infections is difficult because mycobacteria fortify themselves with a thick impermeable cell envelope. Channel and transporter proteins are among the crucial adaptations of Mycobacterium that facilitate their strength to combat against host immune system and anti-tuberculosis drugs. In previous studies, it was in...
Source: Current Chemical Biology - June 30, 2020 Category: Biochemistry Source Type: research
