Effect of Aluminium Chloride Concentration on Diltiazem Hydrochloride Release from pH-sensitive Hydrogel Beads Composed of Hydrolyzed Grafted k-Carrageenan and Sodium Alginate
Conclusion: The preliminary investigation of the beads developed in this study showed a promising sustained release profile of the drug. Therefore, the cross-linked hydrogel beads are promising carriers for oral controlled release of water soluble drug diltiazem HCl. (Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
Biodegradable Polymer Hydrogels Based in Sorbitol and Citric Acid for Controlled Release of Bioactive Substances from Plants (Polyphenols)
Conclusion: Results evidence that E. coli and S. aureus are sensitive to low strictinin concentrations (2.43 mgL-1) released from HGs. (Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
Hydrogels Based in Cassava Starch with Antibacterial Activity for Controlled Release of Cysteamine-silver Nanostructured Agents
Conclusion: Hydrogels can be used as controlled-release systems of substance with antibacterial activity (AgNPs, cysa and AgNPs-cysa). Antibacterial effect against Escherichia coli and Staphylococcus aureus was seen to be relatively low at studied concentrations; however, the charge of antimicrobial activity can be controlled as a result of high water absorption capacity. Inhibition percent for hybrid systems (AgNPs-cysa) was seen to be most effective against Escherichia coli and very similar to the observed effect for AgNPs. (Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
A Study of Correlation between Anti-peroxidative Potential of Quercetin and Ascorbic Acid with Malondialdehyde by RP-HPLC
Conclusion: It was revealed that quercetin and ascorbic acid have beneficial effect to suppress or decrease the drug induced changes in lipid profile of liver samples. (Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
Xanthan Gum a Versatile Biopolymer: Current Status and Future Prospectus in Hydro Gel Drug Delivery
Commercially available, most important microbial polysaccharide is xanthan gum. In many pharmaceutical products and cosmetics, xanthan gum has been widely used as emulsifying and suspending agent. The gelatinous layer creates hinderance to the penetration of water, thereby slowing down the solubilization of the xanthan gum. Its less solubility in polar solvents, is limiting the application of xanthan gum in various drug delivery systems. Biocompatibility, abundance in nature and hydrogel’s similarity with biological systems; are the characteristics of polysaccharides to be chosen as suitable material for biomedical appli...
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
Biodegradable Guar Gum Based Hydrogel for Pharmaceutical Application
Biodegradable and nontoxic natural biopolymers are commonly being studied as a potential carrier material for novel drug delivery system due to its bio-compatible nature. Hydrogels are hydrophilic cross-linked polymer networks. They are able to imbibe large amounts of water or biological fluids. Guar gum (GG) is a galactomannan. It is obtained from plant Cyamopsis Tetragonolobus Linn. It has wide applications in pharmaceutical formulations, cosmetic, food, textile, paper, explosive, toiletries industries, etc. However, due to uncontrollable rate of viscosity, uncontrollable rate of hydration, instability of its solution fo...
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
EDITORIAL: Special Issue: Natural Biopolymer Based Hydrogel in Drug Delivery
(Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
Preface
(Source: Current Chemical Biology)
Source: Current Chemical Biology - April 27, 2017 Category: Biochemistry Source Type: research
Acknowledgements to Reviewers
(Source: Current Chemical Biology)
Source: Current Chemical Biology - November 25, 2016 Category: Biochemistry Source Type: research
Application of Bioinformatics to Investigate the Mutant Alleles of Multiple Endocrine Neoplasia Type 1 on its Structure, Function and Stability
Conclusion: Our results have shown that missense mutations P12L, L22R, E45K, G110E, F144V, I147F, G161D, C170R, E184D and V220M have strong structural, conformational, Function and pathogenic but low tendency order. This research helpful for clinical work at MEN1 genes to find out which mutation is responsible for disease causing. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 25, 2016 Category: Biochemistry Source Type: research
Phylogenetic, Sequence Analysis and Structural Studies of Maturase K Proteins from Mangroves
Conclusion: Thus, this study suggests that matK proteins could be a good candidate for plant systematics and DNA barcoding studies of mangrove species. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 25, 2016 Category: Biochemistry Source Type: research
Binding Interactions of Forskolin with Human Serum Albumin: Insights from In silico and Spectroscopic Studies
Conclusion: The study demonstrates the binding of forskolin to HSA and formation of HSA-forskolin complex. We further hypothesize the imperative role of HSA in the pharmacokinetics of forskolin. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 25, 2016 Category: Biochemistry Source Type: research
Candida easanensis Strain JK-8 β-Glucosidase: A Glucose-Tolerant Enzyme with High Specific Activity for Laminarin
Thermotolerant yeasts, Candida easanensis strain JK-8 secreted a β-glucosidase when grown in liquid media containing various carbon sources. The greatest enzyme activity was found in medium containing 1% cellobiose as a sole carbon source. An extracellular β-glucosidase was purified to homogeneity by anion exchange chromatography and hydrophobic interaction chromatography. The molecular weight (Mw) of the β-glucosidase was estimated to be 48 kDa by SDS-PAGE. The optimal activity was at pH 4.5-5.5 and 60°C. The purified enzyme was stable in the pH range of 4.0-6.0 and had a 2 h half life at 50°C. The presen...
Source: Current Chemical Biology - November 25, 2016 Category: Biochemistry Source Type: research
Ferrous Ion Chelating Modification and Treatment of Iron-Deficiency Anemia of Exopolysaccharide from Lachnum sp.
Conclusion: LEP-1b-Fe is a kind of polysaccharide-iron complex with good therapeutic effect on IDA and improved physical properties. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 25, 2016 Category: Biochemistry Source Type: research
Phytochemicals and Cancer Stem Cells: A Pancreatic Cancer Overview
Among gastro-intestinal cancers, pancreatic cancer is the fourth leading cause of cancer-related death mainly due to late diagnosis. Although there is significant improvement in chemotherapy regimen but still five year survival rate is maximum 6%. Resistance offered by cancer stem cells towards the chemotherapeutic drug might be one solid reason behind this. Cancer stem cells (CSC), a subset of the heterogeneous cell population of a tumor are self-renewable and can differentiate into all types of cancer cells. Inhibition of CSC activity might be a good approach in treatment of cancer. Anti-cancer activities of several natu...
Source: Current Chemical Biology - November 25, 2016 Category: Biochemistry Source Type: research
