Application of Bioinformatics to Investigate the Mutant Alleles of Multiple Endocrine Neoplasia Type 1 on its Structure, Function and Stability

Conclusion: Our results have shown that missense mutations P12L, L22R, E45K, G110E, F144V, I147F, G161D, C170R, E184D and V220M have strong structural, conformational, Function and pathogenic but low tendency order. This research helpful for clinical work at MEN1 genes to find out which mutation is responsible for disease causing.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research