Takeda G-protein Receptor (TGR)-5 Evolves Classical Activestate Conformational Signatures in Complex with Chromolaena Odorata-derived Flavonoid-5,7-dihydroxy-6-4-dimethoxyflavanone
Conclusion: TGR5 evolves active state conformation from a starting intermediate state conformation when bound to COF, which further supports its underlying anti-diabetic activities. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
Prospective of Natural Gum Nanoparticulate Against Cardiovascular Disorders
Conclusion: This problem can be overcome by using natural polymers. Natural gums can be used in nanoparticulate drug delivery systems as reducing and stabilizing agents and in some cases; they may directly or indirectly influence the rate of drug release and absorption from the preparation. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
Emerging Marine Immunomodulatory Small-molecules (2010- Present)
Conclusion: An increasing number of immunomodulatory marine small-molecules with diverse intriguing structure-skeletons were discovered. They may serve as a basis for further studies of marine natural products for their chemistry, related mechanism of action and structure- activity relationships. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
CRISPR-Cas Technology: A Role in Transcriptional Recording and Chromatin Remodeling Events
(Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
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(Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research
Telomere DNA Binding, Cleavage and Anticancer Activity of [Cu(phendione)(Hpyramol)Cl]
Conclusion: The complex [Cu(L)(L’)Cl] was tested for anticancer activity, induced by ROS and DNA cleavage. The IC50 values resulted in nanomolar concentrations with selected cancer cell lines. Relatively the Cu complex shows less toxicity with the normal cell line L132. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
In-Vitro and In-Silico Characterization of Xylose Reductase from Emericella nidulans
Conclusion: Current investigation supported the enzyme’s specific application i.e. bioconversion of xylose to xylitol due to its higher selectivity. In-silico analysis may provide significant structural and physiological information for modifications and improved stability. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
In silico Defining the Repeat-containing Proteins in the Acinetobacter baumannii Proteome, a Great Reservoir of Templates for Synthetic Biology
Conclusion: Repeat containing proteins are important biological determinants of A. baumannii and are well worth researching for finding drug targets and vaccine candidates. These proteins can be served as a template for designing and synthesizing peptides for therapeutic and diagnostic approaches. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
Evaluation of Toll-like Receptor 2 Gene Expression in Rheumatoid Arthritis and Correlation with the Disease Activity
Conclusion: TLR2 pathway may have an important role in RA pathogenesis and could be a new biomarker for diagnosis and monitoring disease activity. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
Preparation and Characterization of PEGylated C18 Fatty Acids/Anti-SNAP25 Antibody-Targeted Liposomes
Conclusion: L1/DP/AS25 was found to be the most stable PEGylated antibody-targeted liposome system because its particle size remained between 90 and 125 nm in 28 days. Transmission electron microscopy observations also supported the incorporation of AS25 and DP on the membrane surface as predicted. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
Antimicrobial Activity of Highly Fluorinated Thiocarbamates and Dithiocarbamates
Conclusion: The fluorinated compounds showed, in general, a relatively more potent antibacterial activity than non-fluorinated counterparts. The results indicate that these thiocarbamates and dithiocarbamates could be promising candidates as potential antimicrobial agents. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
Endogenous Repair System of Oxidative Damage of DNA
DNA is one of the most important biomolecules of living cells which carries genetic information from generation to generation. Many endogenous and exogenous agents may disrupt the structure of DNA. Change in the cellular genome can lead to errors in replication, transcription and in protein synthesis. DNA damage occurs naturally or result from a metabolic and hydrolytic process which release some very active chemical entities like free radicals, Reactive Oxygen Species (ROS), Reactive Nitrogen Intermediate (RNI), Reactive Carbonyl Species (RCS), lipid peroxidation products and alkylating agents. Superoxide radical, hydroxy...
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
Something Old, Something New and Something Used in Alzheimer's; the Idea of Pore, Ethanol and the Use of Oocytes to Understand the Disease
Conclusion: We believe, therefore, that the available data suggest an important role of the amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid aggregates. (Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
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(Source: Current Chemical Biology)
Source: Current Chemical Biology - July 12, 2019 Category: Biochemistry Source Type: research
Screening and Molecular Characterization of Cellulase Producing Actinobacteria from Litchi Orchard
Conclusion: Conclusive evidence on the basis of different parameters established the presence of cellulase producing actinobacteria in the litchi orchard which can convert cellulose into fermentable sugar. (Source: Current Chemical Biology)
Source: Current Chemical Biology - February 8, 2019 Category: Biochemistry Source Type: research
