Protein Flexibility: A Challenging Issue of Drug Discovery

Conclusion: Protein flexibility stands out to be one of the most important and challenging issues for binding and discovering the potent drugs. Proteins may possess several conformations, but to study the nature of the binding site in them, one must consider its binding partner. Thus, only that conformation of protein is involved in the binding in which the structure of binding site is complementary to that of ligand.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research