Clinical Neurology and Neurosurgery 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Ablative surgery for Parkinson ’s disease: Is there still a role for pallidotomy in the deep brain stimulation era?
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease and movement disorder, just after Alzheimer disease and essential tremor, respectively. It is rare before the age of 50, but the prevalence after 60 can range from 1 to 4% in the highest age groups [1], being typically a disease of the elderly. In Brazil, the prevalence in a community-based study was 3.3% above the age of 64 [2]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 23, 2017 Category: Neurosurgery Authors: Bruno Spindola, Marco Ant ônio Leite, Marco Orsini, Erich Fonoff, José Alberto Landeiro, Bruno Lima Pessoa Source Type: research
miziA patient with autoimmune limb-girdle myasthenia, and a brief review of this treatable condition.
Limb-girdle myasthenia gravis (LGM) is an uncommon clinical picture with a peculiar proximal distribution of the muscle weakness with no ocular, bulbar or facial deficit. This condition could mimic some myopathies or be caused by congenital defects of the neuromuscular transmission. However such an onset is more frequent during infancy then in adulthood. The diagnosis of myasthenia could be suggested by: the decremental responses to repetitive nerve stimulation (RNS), the thymus pathology, or the evidence, despite rarely found, of anti-acetylcholine receptor antibodies (AchRAbs) [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 23, 2017 Category: Neurosurgery Authors: Domizia Vecchio, Claudia Varrasi, Cristoforo Comi, Paolo Ripellino, Roberto Cantello Tags: Review Source Type: research
Identification of clinical and paraclinical findings predictive for headache occurrence during spontaneous subarachnoid hemorrhage
Non traumatic (spontaneous) subarachnoid hemorrhage (SAH) represents about 5% of cerebrovascular pathology and it is associated with the significant rate of complications such as rebleeding (within first four weeks), with significant mortality (up to half of patients die within three weeks) and long term disability (a third of survivors remain dependent) [1 –3]. Unfortunately, the initially presenting symptoms of SAH are manifold and can be subtle and overlap with commonly frequent conditions, such as coexisting patients‘ diseases or its complications. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 22, 2017 Category: Neurosurgery Authors: Srdjan Ljubisavljevic, Vuk Milosevic, Aleksandar Stojanov, Marina Ljubisavljevic, Olivera Dunjic, Miroslava Zivkovic Source Type: research
Increased expression of P2X7 receptor in peripheral blood mononuclear cells correlates with clinical severity and serum levels of Th17-related cytokines in patients with myasthenia gravis
Myasthenia gravis (MG) is an autoimmune-mediated neuromuscular disease and its incidence has been increasing lately[1]. The disorder is caused by antibodies binding to components in the neuromuscular junction, impairing neuromuscular transmission. Over 80% of patients have antibodies against acetylcholine receptor (AChR) [2]. AChR-specific CD4+ T cells i.e. T-help cells, which can be detected in most MG patients, likely have an important role in MG, because they modulate the synthesis of anti-AChR Ab and may be the prime movers in the pathogenesis of MG[3]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 19, 2017 Category: Neurosurgery Authors: Yong Zhang, Yanyan Zhang, Hao Li, Xiao Jia, Xiuying Zhang, Yan Xia, YuZhong Wang, Linlin Fu, Chenghua Xiao, Deqin Geng Source Type: research
A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer)
Lynch syndrome (hereditary nonpolyposis colorectal cancer) is an autosomal dominant disorder characterized by a significant risk of colorectal and endometrial cancers. A variety of other epithelial cancers may be associated with this syndrome, including ovarian, gastric, small bowel, hepatobiliary, renal, ureteral, skin, breast, prostate, and pancreatic cancers. Brain tumors are infrequent, but have been reported in series [1]. Individuals who have biallelic Lynch syndrome mutations in MLH1, MSH-2, MSH-6, or PMS-2 have a childhood-onset disorder now referred to as constitutional mismatch repair deficiency syndrome, in whic...
Source: Clinical Neurology and Neurosurgery - April 19, 2017 Category: Neurosurgery Authors: Sanjay Hinduja, Celia D. DeLozier, Stevan R. Knezevich, William R. Silveira, Viola W. Zhu Tags: Case Report Source Type: research
A New Quantitative Method to Assess Disproportionately Enlarged Subarachnoid Space (DESH) in Patients with Possible Idiopathic Normal Pressure Hydrocephalus: The SILVER Index
Idiopathic normal-pressure hydrocephalus (iNPH) is a surgically treatable form of dementia clinically associated with gait disturbance and urinary incontinence, as initially described by Hakim and Adams [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 19, 2017 Category: Neurosurgery Authors: Nicola Benedetto, Carlo Gambacciani, Filippo Aquila, Davide Tiziano Di Carlo, Riccardo Morganti, Paolo Perrini Tags: Full Length Article Source Type: research
Anterior lumbar interbody fusion with percutaneous pedicle screw fixation for multiple-level isthmic spondylolisthesis
Isthmic spondylolisthesis is caused by a defect in the pars interarticularis area of the lamina. Among the general population, the estimated incidence of isthmic spondylolisthesis is 2.6% –4.4% [1]. Lumbar isthmic spondylolisthesis occurs most commonly at a single spinal level, typically the L5–S1. Only a few cases of multiple-level isthmic spondylolisthesis have been reported in the literature [2–4]. Here, we report 23 cases of multiple-level isthmic spondylolisthesis and desc ribe clinical, radiological and treatment features. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 14, 2017 Category: Neurosurgery Authors: Chang-Sheng Hsieh, Hyung Chang Lee, Hyeong-Seok Oh, Sang-Joon Park, Byeong-Wook Hwang, Sang-Ho Lee Source Type: research
The visualization of the surgical field in tubular assisted spine surgery: Is there a difference between HD-endoscopy and microscopy?
A basic tenet in surgery is to treat pathologies effectively by preserving the normal anatomy. Since Yasargil and Casper introduced the microscope to spinal surgery in 1977 [1,2] microdiscectomy is considered to be the gold standard for the treatment of this disease [3 –5]. However, surgeons were seeking for new surgical techniques to further reduce the intraoperative tissue trauma and the perioperative discomfort of the patient. The idea of minimally invasive spinal surgery triggered the development of new surgical techniques and new tools for better illuminati on and magnification [6–9]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 10, 2017 Category: Neurosurgery Authors: Benedikt W. Burkhardt, M. Wilmes, Salman Sharif, Joachim M. Oertel Tags: Full Length Article Source Type: research
The reappearance of hemiplegic cluster headaches: A case report and review of the literature
Cluster headache (CH) is a rare and severe syndrome characterized by the recurrence of unilateral pain attacks localized on the orbital or temporal regions, of short duration (15-180minutes), and associated with ipsilateral autonomic symptoms such as conjunctival injection, lacrimation, nasal congestion, ptosis or eyelid edema. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 10, 2017 Category: Neurosurgery Authors: Jacopo Fantini, Arianna Sartori, Antonio Granato, Paolo Manganotti Source Type: research
The visualization of the surgical field in tubular assisted spine surgery is there a difference between HD-endoscopy and microscopy?
A basic tenet in surgery is to treat pathologies effectively by preserving the normal anatomy. Since Yasargil and Casper introduced the microscope to spinal surgery in 1977 [1,2] microdiscectomy is considered to be the gold standard for the treatment of this disease [3 –5]. However, surgeons were seeking for new surgical techniques to further reduce the intraoperative tissue trauma and the perioperative discomfort of the patient. The idea of minimally invasive spinal surgery triggered the development of new surgical techniques and new tools for better illuminati on and magnification [6–9]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 10, 2017 Category: Neurosurgery Authors: Benedikt W. Burkhardt, M. Wilmes, Salman Sharif, Joachim M. Oertel Source Type: research
Endothelin Polymorphisms as a Risk Factor for Cerebral Aneurysm Rebleeding Following Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) represents a unique form of hemorrhagic stroke due to rupture of an intradural cerebral aneurysm and is associated with high rates of morbidity and mortality. Considerable variation in the annual incidence of aSAH exists among different regions of the world with an incidence ranging from 2 to 16 cases per 100,000 [1,2]. Following the diagnosis of aSAH, early surgical or endovascular treatment of the aneurysm is recommended to reduce the rate of aneurysm rerupture [2]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 7, 2017 Category: Neurosurgery Authors: Paul M. Foreman, Robert M. Starke, Philipp Hendrix, Mark R. Harrigan, Winfield S. Fisher, Nilesh A. Vyas, Robert H. Lipsky, Minkuan Lin, Beverly C. Walters, Jean-Francois Pittet, Mali Mathru, Christoph J. Griessenauer Source Type: research
Reduction of Retinal Nerve Fiber Layer Thickness in Vigabatrin-Exposed Patients: a Meta-Analysis
Epilepsy is considered as a group of neurological diseases, and characterized by epileptic seizures[1]. The prevalence of this disease is 0.5 –1%, with an overall rate of complete seizure controlled by drug treatment in 40–50% of epileptic patients[2]. Vigabatrin (VGB), an inhibitor of γ-aminobutyric (GABA) transaminase, is currently served as an effective adjunctive therapy for epilepsy patients with partial onset seizures [3–5] a nd as a monotherapy for infantile spasm [6,7].Unfortunately, asymptomatic visual field defects were recognized as side effects caused by treatment of VGB, and many studies have shown that...
Source: Clinical Neurology and Neurosurgery - April 6, 2017 Category: Neurosurgery Authors: Yingqian Peng, Yinan Zhao, Wenyu Hu, Yongmei Hu, Yan He, Yedi Zhou Tags: Full length article Source Type: research
Cheiro-pedal syndrome: A Revisit of Etiology, Localization and Outcome
The characteristic distribution and pattern of somatosensory impairment can greatly promote the accuracy for predicting the localization and differentiation in clinical practice, like Brown-S équard syndrome in spinal cord and sensory deficit of Stopford type in medulla oblongata. The family of restricted acral sensory syndrome (RASS) consists of a constellation of incomplete sensory disorders confined to the distal part of limbs and/or face. [1,2] It can occur at a single site or multi ple sites separated distantly, [2] such as the cheiro-oral syndrome (COS)[3] and other analogues. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 6, 2017 Category: Neurosurgery Authors: Wei-Hsi Chen, Hung-Sheng Lin, Chi Chui, Hsin-Ling Yin Source Type: research
Internet Search Volumes in Brain Aneurysms and Subarachnoid Hemorrhage: Is There Evidence of Seasonality?
Studying risk factors for aneurysmal subarachnoid hemorrhage (SAH) allows for better understanding of pathophysiology, improved preventative strategies, and more efficient use of limited healthcare resources. Some risk factors, such as hypertension, smoking, and ethnicity are well-known1, but other often-overlooked factors such as meteorological conditions and seasonality, are still topics of controversy. Some previous studies have shown an increase in the occurrence of SAH in the wintertime and a nadir in the summer [2 –5], whereas others have instead reported a increase in the spring [3], summer [6], or autumn [7]. (So...
Source: Clinical Neurology and Neurosurgery - April 6, 2017 Category: Neurosurgery Authors: Jerry Ku, Naif M. Alotaibi, Justin Wang, George M. Ibrahim, Tom A. Schweizer, R.Loch Macdonald Source Type: research
Gender-Related Differences in Aneurysmal Subarachnoid Hemorrhage: A Hospital Based Study
The incidence of aneurysmal subarachnoid hemorrhage (aSAH) is 50% higher in women than in men [1,2]. Possible reasons for such a gender gap include repeated childbirths, hormonal factors, higher hemodynamic forces acting on the intracranial vessel wall, and a more severe impact of smoking on women [3 –6]. Repeated childbirths are associated with an increased risk of aSAH, possibly through pregnancy-induced hypertension and vascular tension during delivery, which weakens vessels and may lead to aneurysm formation [3]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 6, 2017 Category: Neurosurgery Authors: Gian Marco De Marchis, Chris Schaad, Christian Fung, Juergen Beck, Jan Gralla, Jukka Takala, Stephan M. Jakob Source Type: research
