Clinical Neurology and Neurosurgery This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Chorea gravidarum associated with Moyamoya angiopathy treated with alpha-methyldopa
We recently published a first systematic study concerning movement symptoms in Moyamoya disease in this journal [1]. Moyamoya disease is a cerebrovascular disorder characterized by bilateral progressive narrowing and occlusion of the distal internal carotid artery and adjacent basal cranial vessels with development of characteristic collateral circulation. We recently published that movement symptoms are more often than traditionally thought to be [1]. Several underlying mechanisms have been discussed, comprising cerebral ischemia and diffuse hypoperfusion as well as hormonal factors [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 6, 2017 Category: Neurosurgery Authors: Jens Platzen, Peter Berlit, Markus Kraemer Tags: Letter to the Editor Source Type: research

Resource Utilization for Non-operative Cervical Radiculopathy: Management by Surgeons versus Non-surgeons
Cervical radiculopathy is a relatively prevalent condition with an estimated incidence of 1.79 occurrences per 1000 person-years [1]. It is most commonly attributed to disc or spondylotic pathologies [2], although other etiologies include degenerative changes and inflammatory responses [3,4]. The vast majority of patients with such conditions improve with non-operative modalities such as medications, physical therapy, corticosteroid injections, or chiropractic and acupuncture techniques [1,5]. In specific situations, such as failure to improve with non-operative treatment, surgery may be an appropriate option [6,7]. (Sourc...
Source: Clinical Neurology and Neurosurgery - May 6, 2017 Category: Neurosurgery Authors: Sophie H. Chung, Daniel D. Bohl, Jonathan T. Paul, Jeffrey A. Rihn, James S. Harrop, Zoher Ghogawala, Alan S. Hilibrand, Jonathan N. Grauer Source Type: research

Different patterns of gelatinolytic activity in pituitary macro- and microadenomas
Gelatinases, Matrix MetalloProteinase(MMP)-2 and MMP-9, belong to zinc-dependent endopeptidases involved in several physiological and pathological processes including inflammation and tumor development [1]. Both enzymes are capable of damaging extracellular matrix (ECM) proteins leading to the facilitation of carcinogenesis [2,3]. Although gelatinases are studied in numerous aggressive tumors the literature about their role in the pathogenesis of pituitary adenomas (PA) is scant. Overexpression of MMP-2 and MMP-9 in tumor tissue was noticed in an invasive PA [4,5]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 4, 2017 Category: Neurosurgery Authors: Daniel Babula, Joanna Kocot, Anna Horecka, Marcin Baran, Jacek Kurzepa Source Type: research

Guillain-Barr é Syndrome, variants & forms fruste: Reclassification with new criteria
Clinical phenotypes and electrophysiology characteristics play important roles in Guillain-Barr é syndrome (GBS) diagnosis, subtypes classification and prognosis. Although GBS commonly presents as acute flaccid paralytic polyradiculoneuropathy with or without cranial nerves involvement, several clinically distinctive forms fruste have been described, in addition to Miller-Fisher syndrome (MFS ), which is defined by the unique clinical triad, or in isolation, of ophthalmoplegia, ataxia, and areflexia [1,2]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 4, 2017 Category: Neurosurgery Authors: Fu Liong Hiew, Rahmansah Ramlan, Shanthi Viswanathan, Santhi Puvanarajah Source Type: research

Genetic and epigenetic alterations in meningiomas
Meningiomas represent the most common primary tumors of the central nervous system, making up nearly one third of all primary intracranial tumors [1] and having an incidence of 4.4 cases per 100,000 person-years [2]. Intracranial meningiomas are more common in women than men and frequently occur in patients aged 50 –60 years [3]. There is evidence that the incidence of meningiomas in patients older than 70 is 3.5 times higher than in those under 70 in both sexes [4]. Autopsy and imagingstudies indicate that the incidence of meningiomas is roughly 3% in the population [5]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 3, 2017 Category: Neurosurgery Authors: Vasiliki Galani, Evangeli Lampri, Anna Varouktsi, George Alexiou, Antigoni Mitselou, Athanasios P. Kyritsis Tags: Topic review Source Type: research

Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human biliverdin reductase
In neurological oncology surgery practice, meningiomas as extra-axial and gliomas as intra-axial tumors are the most common brain tumors and despite modern treatment modalities, we are still far from the total cure, especially in high-grade gliomas (HGG) and again in high-grade meningiomas. Even in low-grade gliomas (LGG), recurrence or up-grading is encountered within 5 –7 years following the first surgery, although total removal has been achieved. Low-grade meningiomas such as grade-I, has also recurrence rate which is very low but possible. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 3, 2017 Category: Neurosurgery Authors: Pinar Atukeren, Sena Oner, Oguz Baran, Rahsan Kemerdere, Bulent Eren, Ufuk Cakatay, Taner Tanriverdi Source Type: research

Revisiting racial disparities in access to surgical management of drug-resistant temporal lobe epilepsy post implementation of Affordable Care Act
Racial and socioeconomic disparities have existed in the United States (US) healthcare system for decades [1]. Disparities in access to healthcare facilities for maintenance of chronic medical conditions, non-surgical interventions and surgical treatments have been exemplified in many previous studies. [2 –5] These disparities are more profound for elective surgical procedures, both in receipt of surgery and post-surgical outcomes. In neurosurgery, disparities in access to neuro-oncologic care at high-volume hospitals and outcomes have been noted particularly in African Americans (AAs) and Hispanic s as compared to Cauca...
Source: Clinical Neurology and Neurosurgery - May 2, 2017 Category: Neurosurgery Authors: Kanika Sharma, Piyush Kalakoti, Miriam Henry, Vikas Mishra, Rosario Maria Riel-Romero, Christina Notarianni, Anil Nanda, Hai Sun Source Type: research

Effects of preadmission beta-blockers on neurogenic stunned myocardium after aneurysmal subarachnoid hemorrhage: a meta- Analysis
Subarachnoid hemorrhage (SAH) may be induced by two reasons: trauma and spontaneity (aneurysmal, 75% –80%, and nonaneurysmal). The peak age of the aneurysmal subarachnoid hemorrhage was 55-60 years old, Clinical manifestations of SAH included sudden severe headache, vomiting, syncope, and the irritation of the brain. Despite of the advance in medical and surgical management, aneurysmal subarachno id hemorrhage (aSAH) remains a disease with significant morbidity and mortality. The complications of aSAH included hydrocephalus (obstructive and traffic), neurogenic pulmonary edema, neurogenic stunned myocardium (NSM) [1–4]...
Source: Clinical Neurology and Neurosurgery - May 1, 2017 Category: Neurosurgery Authors: Hai Luo, Wei-xin Song, Jin-wen Jiang, Jian-lan Zhao, Wei-lin Rong, Mei-hua Li Source Type: research

Revisiting Bilateral Thalamotomy for Tremor
Deep brain stimulation (DBS) has been the predominant surgical procedure for movement disorders in the 21st century. Numerous studies document its capacity to improve motor symptoms of patients with essential tremor, Parkinson ’s disease (PD) and dystonia over best medical management [1–5]. Although creation of surgical lesions was widely performed for similar indications prior to the introduction of DBS, the adjustable nature of stimulation is felt to allow for a more optimal balance between relief of motor symptoms and negative impact on neighboring brain function [6]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 1, 2017 Category: Neurosurgery Authors: Jumana Alshaikh, Paul S. Fishman Source Type: research

Usefulness of StereoEEG-based tailored surgery for medial temporal lobe epilepsy. Preliminary results in 11 patients
Medial temporal lobe epilepsy (MTLE) typically shows hippocampal atrophy or hippocampal high signal intensity, on fluid attenuated inversion recovery (FLAIR) sequences acquired through magnetic resonance imaging (MRI) [1,2]. There is also a typical semiological progression from rising epigastric sensations to motor manifestations, which may include automatism or behavioral arrest [3]. In terms of etiology, hippocampal sclerosis is likely to be the underlying pathological substrate [4]; however, coexistent additional epileptogenic lesions have been reported, including focal cortical dysplasia and neuroepithelial tumors in o...
Source: Clinical Neurology and Neurosurgery - May 1, 2017 Category: Neurosurgery Authors: Yuichi Kubota, Taku Ochiai, Tomokatsu Hori, Takakazu Kawamata Source Type: research

Editorial Board
(Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 30, 2017 Category: Neurosurgery Source Type: research

Development of a prognostic scale for severely hemiplegic stroke patients in a rehabilitation hospital
There are many goals involved with stroke rehabilitation. The main goals are: (1) the ability to walk; (2) to improve the activities of daily living (ADL); and (3) to return home after recovery. To date, different scales have been proposed in stroke rehabilitation for the prediction of the prognosis in terms of the ability to walk [1 –3], ability to carry out ADL [4–6], duration of hospital stay [7–9], and destination [10]. However, most of these methods are aimed at predicting a single goal, and as a result, they allowed for the extraction of factors that are important for the prognosis of the concerned goals, but d...
Source: Clinical Neurology and Neurosurgery - April 28, 2017 Category: Neurosurgery Authors: Yoshitake Hirano, Osamu Nitta, Takeshi Hayashi, Hidetoshi Takahashi, Yasuhiro Miyazaki, Hiroshi Kigawa Source Type: research

Neurological outcomes of antidiabetic therapy: What the neurologist should know
The prevalence of diabetes mellitus still seems to be on the rise in many industrialized countries, and negative impacts on the prevalence of diabetes complications might be anticipated. Therefore, the potential preventive effect of antidiabetic drugs to reduce diabetes complications has met increasing interest, particularly as the number of available diabetes drugs has increased considerably in recent years. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 24, 2017 Category: Neurosurgery Authors: Olaf Eberhardt Md, Helge Topka Md Source Type: research

An Evaluation of Internet Use by Neurosurgery Patients Prior to Lumbar Disc Surgery and of Information Available on Internet
Low back pain is the second most common reason for admission to a healthcare institution and is a major public health problem [1 –3]. Eighty-four percent of the population suffers from low back pain at some period of their lives. The complaints usually resolve within 2-4 weeks with medical treatment or even without any treatment. Lumbar disc hernia-related pain is seen in about 39% of the cases [4]. Lumbar disc pathologies are mostly treated with conservative methods, but surgical intervention is required in 1-2% of the cases [5]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 24, 2017 Category: Neurosurgery Authors: Ibrahim Burak Atci, Hakan Yilmaz, Umit Kocaman, Mustafa Yavuz Samanci Tags: Research Article Source Type: research

A patient with autoimmune limb-girdle myasthenia, and a brief review of this treatable condition.
Limb-girdle myasthenia gravis (LGM) is an uncommon clinical picture with a peculiar proximal distribution of the muscle weakness with no ocular, bulbar or facial deficit. This condition could mimic some myopathies or be caused by congenital defects of the neuromuscular transmission. However such an onset is more frequent during infancy then in adulthood. The diagnosis of myasthenia could be suggested by: the decremental responses to repetitive nerve stimulation (RNS), the thymus pathology, or the evidence, despite rarely found, of anti-acetylcholine receptor antibodies (AchRAbs) [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - April 23, 2017 Category: Neurosurgery Authors: Domizia Vecchio, Claudia Varrasi, Cristoforo Comi, Paolo Ripellino, Roberto Cantello Tags: Review Source Type: research