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Cognitive performance, fatigue and event-related potentials in patients with clinically isolated syndrome.
Multiple sclerosis (MS) is a chronic disease of the central nervous system with a background associated with immune-mediated demyelinating processes accompanied by axonal loss. Multifocal and diffuse damage to the brain results in a diversity of symptoms and signs of neurological deficit. Among these, cognitive impairment and fatigue have already been recognized and investigated because they substantially affect patients' social and vocational functioning [1 –4]. Impaired cognitive performance is reported in 30-70% of MS patients and is still supposed to be underestimated [1,2]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - July 13, 2016 Category: Neurosurgery Authors: Anna Pokryszko-Dragan, Edyta Dziadkowiak, Mieszko Zagrajek, Krzysztof Slotwinski, Ewa Gruszka, Malgorzata Bilinska, Ryszard Podemski Source Type: research

Cognitive performance, fatigue and event-related potentials in patients with clinically isolated syndrome.
Multiple sclerosis (MS) is a chronic disease of the central nervous system with a background associated with immune-mediated demyelinating processes accompanied by axonal loss. Multifocal and diffuse damage to the brain results in a diversity of symptoms and signs of neurological deficit. Among these, cognitive impairment and fatigue have already been recognized and investigated because they substantially affect patients' social and vocational functioning [1–4]. Impaired cognitive performance is reported in 30-70% of MS patients and is still supposed to be underestimated [1,2]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - July 13, 2016 Category: Neurosurgery Authors: Anna Pokryszko-Dragan, Edyta Dziadkowiak, Mieszko Zagrajek, Krzysztof Slotwinski, Ewa Gruszka, Malgorzata Bilinska, Ryszard Podemski Source Type: research

Paraneoplastic opsoclonus associated with squamous cell carcinoma of the tongue
Opsoclonus is a pathological eye movement phenomenon in which the eyes experience involuntary, arrhythmic, rapid, multidirectional, conjugate movements. It occurs in all eye positions and during smooth pursuit, and can also persist during sleep. It is differentiated from nystagmus in that there is no slow eye movement phase, and it differs from ocular flutter because the eye movement is multidirectional and not confined to the horizontal. Opsoclonus can be accompanied by tremors, cerebellar ataxia, myoclonic jerks, or encephalopathy. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - July 12, 2016 Category: Neurosurgery Authors: DonRaphael Wynn, Joseph Merriman, Ami B. Patel, Ying J. Hitchcock, Ignacio Garrido-Laguna, David Renner, Stacey L. Clardy Tags: Case Report Source Type: research

Effectiveness and safety of natalizumab in real-world clinical practice: review of observational studies
Clinical trials have shown that natalizumab is highly effective for treating relapsing forms of multiple sclerosis (MS). The purpose of this analysis was to conduct a targeted review of data from country-specific observational studies and registries of natalizumab-treated patients with relapsing MS in order to more fully investigate the longer-term effectiveness and safety of this disease-modifying therapy in real-world clinical practice settings. A PubMed search was conducted on March 13, 2014, using the terms (natalizumab AND multiple sclerosis) AND (observational OR registry OR post-marketing OR clinical practice). (Sou...
Source: Clinical Neurology and Neurosurgery - July 12, 2016 Category: Neurosurgery Authors: Vincent van Pesch, Christian J. Sindic, Oscar Fern ández Source Type: research

Is Susac syndrome associated with bipolar disorder?
Susac ’s Syndrome (SS) is a rare autoimmune disorder affecting the precapillary arterioles of the brain, retina, and cochlea. Young women, in particular, are at risk, but the disorder can also affect males (3.5 female/1 male) [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - July 12, 2016 Category: Neurosurgery Authors: Clea Staelens, Kurt Audenaert, Hannelore Tandt, Gilbert Lemmens, Veroniek Van Driessche Tags: Case report Source Type: research