Reduction of Retinal Nerve Fiber Layer Thickness in Vigabatrin-Exposed Patients: a Meta-Analysis

Epilepsy is considered as a group of neurological diseases, and characterized by epileptic seizures[1]. The prevalence of this disease is 0.5 –1%, with an overall rate of complete seizure controlled by drug treatment in 40–50% of epileptic patients[2]. Vigabatrin (VGB), an inhibitor of γ-aminobutyric (GABA) transaminase, is currently served as an effective adjunctive therapy for epilepsy patients with partial onset seizures [3–5] a nd as a monotherapy for infantile spasm [6,7].Unfortunately, asymptomatic visual field defects were recognized as side effects caused by treatment of VGB, and many studies have shown that VGB can cause toxicity to eye in terms of visual field constrictions [8–11].
Source: Clinical Neurology and Neurosurgery - Category: Neurosurgery Authors: Tags: Full length article Source Type: research