Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy [Original Articles]
Conclusions—
The benefit of sacubitril/valsartan, over an angiotensin-converting enzyme inhibitor, was consistent regardless of background therapy and irrespective of previous coronary revascularization or β-blocker dose.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01035255. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 11, 2016 Category: Cardiology Authors: Okumura, N., Jhund, P. S., Gong, J., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Swedberg, K., Zile, M. R., Solomon, S. D., Packer, M., McMurray, J. J. V., on behalf of the PARADIGM-HF Investigators and Committees* Tags: Clinical Studies, Heart Failure, Treatment, Mortality/Survival Original Articles Source Type: research
Early Follow-Up After a Heart Failure Exacerbation: The Importance of Continuity [Original Articles]
Conclusions—
Outpatient follow-up within 14 days after HF exacerbation requiring hospitalization or emergency department visit is associated with better outcomes, particularly if the follow-up is with a familiar physician. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 11, 2016 Category: Cardiology Authors: McAlister, F. A., Youngson, E., Kaul, P., Ezekowitz, J. A. Tags: Heart Failure, Health Services, Mortality/Survival Original Articles Source Type: research
Histological and Histometric Characterization of Myocardial Fibrosis in End-Stage Hypertrophic Cardiomyopathy: A Clinical-Pathological Study of 30 Explanted Hearts [Original Article]
Conclusions—
In end-stage, hypertrophic cardiomyopathy patients undergoing transplantation, more than one-third of the left ventricular myocardium was replaced by fibrosis, mainly of replacement type. MF preferentially involved the left ventricular apex and the midwall. Inferior and anterior walls and septum were maximally involved, whereas inferolateral and right ventricular were usually spared. These observations reflect the complex pathophysiology of hypertrophic cardiomyopathy and may provide clues for the timely recognition of disease progression by imaging techniques capable of quantifying MF. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 11, 2016 Category: Cardiology Authors: Galati, G., Leone, O., Pasquale, F., Olivotto, I., Biagini, E., Grigioni, F., Pilato, E., Lorenzini, M., Corti, B., Foa, A., Agostini, V., Cecchi, F., Rapezzi, C. Tags: Fibrosis, Cardiomyopathy, Heart Failure, Magnetic Resonance Imaging (MRI), Transplantation Original Article Source Type: research
Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines? [Original Article]
Conclusions—
Our findings suggest, for the first time, that skeletal muscle alterations are exacerbated in HFrEF compared with HFpEF, which predominantly reside in limb, rather than in respiratory, muscle. This disparity may be mediated, in part, by the different circulating inflammatory cytokines that were elevated between HFpEF and HFrEF. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - September 7, 2016 Category: Cardiology Authors: Seiler, M., Bowen, T. S., Rolim, N., Dieterlen, M.-T., Werner, S., Hoshi, T., Fischer, T., Mangner, N., Linke, A., Schuler, G., Halle, M., Wisloff, U., Adams, V. Tags: Basic Science Research, Growth Factors/Cytokines, Oxidant Stress, Pathophysiology, Heart Failure Original Article Source Type: research
Deflation Timing Influences Intra-Aortic Balloon Pump-Mediated Carotid Blood Flow Reversal: A Case Report [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 30, 2016 Category: Cardiology Authors: Schutt, R. C., Bhimiraj, A., Estep, J. D., Guha, A., Trachtenberg, B. H., Garami, Z. Tags: Cardiomyopathy, Ultrasound Images and Case Reports in Heart Failure Source Type: research
Established and Emerging Roles of Biomarkers in Heart Failure Clinical Trials [Development of Therapeutics for Heart Failure]
The role of circulating biomarkers in heart failure clinical trials has evolved in recent decades. Increasing evidence behind the use of natriuretic peptides, emergence of novel biomarkers, and increased emphasis on targeting therapies toward physiological basis of disease (so-called precision medicine) have all contributed to the continued expansion of biomarker use in heart failure clinical trials. We will explore the advantages and pitfalls encountered through the use of biomarkers in clinical trials as an inclusion criterion, toxicity marker, and end point. We will also review their role in providing insights into the ...
Source: Circulation: Heart Failure - August 30, 2016 Category: Cardiology Authors: Ibrahim, N. E., Gaggin, H. K., Konstam, M. A., Januzzi, J. L. Tags: Biomarkers, Heart Failure Development of Therapeutics for Heart Failure Source Type: research
Model Building as an Educational Hobby [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 10, 2016 Category: Cardiology Authors: Stevenson, L. W., Davis, R. B. Tags: Heart Failure Editorial Source Type: research
Multistate Model to Predict Heart Failure Hospitalizations and All-Cause Mortality in Outpatients With Heart Failure With Reduced Ejection Fraction: Model Derivation and External Validation [Original Article]
Conclusions—
Our findings illustrate the advantages of a multistate modeling approach, providing estimates of HF hospitalization and death in the same model, comparison of predictors for the different outcomes and demonstrating the different trajectories of patients based on baseline characteristics and intermediary events.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00000609 and NCT00090259. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 10, 2016 Category: Cardiology Authors: Upshaw, J. N., Konstam, M. A., Klaveren, D. v., Noubary, F., Huggins, G. S., Kent, D. M. Tags: Cardiomyopathy, Heart Failure, Mortality/Survival, Quality and Outcomes Original Article Source Type: research
Implications of Using Different Definitions on Outcomes in Worsening Heart Failure [Original Article]
Conclusions—
A WHF definition that excluded the intensification of diuretics resulted in a lower event rate but a stronger association with outcomes. These data support the need for continued efforts to standardize WHF definitions in clinical trials.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00577135 (DOSE) and NCT01132846 (ROSE). (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 10, 2016 Category: Cardiology Authors: Kelly, J. P., Cooper, L. B., Gallup, D., Anstrom, K. J., Chen, H. H., Redfield, M. M., OConnor, C. M., Mentz, R. J., Hernanadez, A. F., Felker, G. M. Tags: Heart Failure Original Article Source Type: research
Validation and Comparison of Seven Mortality Prediction Models for Hospitalized Patients With Acute Decompensated Heart Failure [Original Article]
Conclusions—
Four clinically derived, inpatient, HF mortality models exhibited similar performance, with C statistics near 0.70. Three other models, 1 developed in electronic health record data and 2 developed in administrative data, also were predictive, with C statistics from 0.76 to 0.80. Because every model performed acceptably, the decision to use a given model should depend on practical concerns and intended use. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 10, 2016 Category: Cardiology Authors: Lagu, T., Pekow, P. S., Shieh, M.-S., Stefan, M., Pack, Q. R., Amin Kashef, M., Atreya, A. R., Valania, G., Slawsky, M. T., Lindenauer, P. K. Tags: Heart Failure Original Article Source Type: research
Association of Weight and Body Composition on Cardiac Structure and Function in the ARIC Study (Atherosclerosis Risk in Communities) [Original Article]
Conclusions—
In a large, biracial cohort of older adults free of clinically overt coronary heart disease or heart failure, obesity was associated with subclinical abnormalities in cardiac structure in both men and women and with adverse LV remodeling and impaired LV systolic function in women. These data highlight the association of obesity and subclinical abnormalities of cardiac structure and function, particularly in women. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 9, 2016 Category: Cardiology Authors: Bello, N. A., Cheng, S., Claggett, B., Shah, A. M., Ndumele, C. E., Roca, G. Q., Santos, A. B. S., Gupta, D., Vardeny, O., Aguilar, D., Folsom, A. R., Butler, K. R., Kitzman, D. W., Coresh, J., Solomon, S. D. Tags: Obesity, Remodeling, Echocardiography Original Article Source Type: research
Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure) [Original Article]
Conclusions—
In this post hoc analysis of ROSE AHF, the response to vasoactive therapies differed in patients with heart failure with reduced EF and heart failure with preserved EF. Investigations of AHF therapies should assess the potential for differential responses in AHF with preserved versus reduced EF.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01132846. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 9, 2016 Category: Cardiology Authors: Wan, S.-H., Stevens, S. R., Borlaug, B. A., Anstrom, K. J., Deswal, A., Felker, G. M., Givertz, M. M., Bart, B. A., Tang, W. H. W., Redfield, M. M., Chen, H. H. Tags: Cardiorenal Syndrome, Heart Failure Original Article Source Type: research
Putting Life in the Years: Incorporating Quality of Life Into Left Ventricular Assist Devices Outcomes [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 8, 2016 Category: Cardiology Authors: Stewart, G. C. Tags: Heart Failure, Quality and Outcomes Editorial Source Type: research
Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights [Original Article]
Conclusions—
Hypochloremia is associated with neurohormonal activation and diuretic resistance with chloride depletion as a candidate mechanism. Sodium-free chloride supplementation was associated with increases in serum chloride and changes in several cardiorenal parameters.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT02031354. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 8, 2016 Category: Cardiology Authors: Hanberg, J. S., Rao, V., ter Maaten, J. M., Laur, O., Brisco, M. A., Perry Wilson, F., Grodin, J. L., Assefa, M., Samuel Broughton, J., Planavsky, N. J., Ahmad, T., Bellumkonda, L., Wilson Tang, W. H., Parikh, C. R., Testani, J. M. Tags: Cardiorenal Syndrome, Heart Failure Original Article Source Type: research
Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure [Original Article]
Conclusions—
Low serum chloride at AHF hospital admission was strongly associated with impaired decongestion. New or persistent hypochloremia 14 days later was independently associated with reduced survival, whereas hypochloremia that resolved by day 14 was not.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00354458. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 8, 2016 Category: Cardiology Authors: ter Maaten, J. M., Damman, K., Hanberg, J. S., Givertz, M. M., Metra, M., OConnor, C. M., Teerlink, J. R., Ponikowski, P., Cotter, G., Davison, B., Cleland, J. G., Bloomfield, D. M., Hillege, H. L., van Veldhuisen, D. J., Voors, A. A., Testani, J. M. Tags: Heart Failure Original Article Source Type: research
