Balancing Bleeding and Clotting: The Known Unknowns of Mechanically Assisted Circulation [Editorials]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 12, 2017 Category: Cardiology Authors: Rogers, J. G. Tags: Heart Failure, Anticoagulants, Cardiovascular Surgery, Treatment Editorials Source Type: research
Increased Thromboembolic Events With Dabigatran Compared With Vitamin K Antagonism in Left Ventricular Assist Device Patients: A Randomized Controlled Pilot Trial [Original Articles]
Conclusions—
Thromboembolic events on dabigatran led to early termination of a randomized controlled trial of dabigatran versus phenprocoumon in left ventricular assist device patients.
Clinical Trial Registration—
https://www.clinicaltrials.gov. Unique identifier: NCT02872649. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 12, 2017 Category: Cardiology Authors: Andreas, M., Moayedifar, R., Wieselthaler, G., Wolzt, M., Riebandt, J., Haberl, T., Angleitner, P., Schloglhofer, T., Wiedemann, D., Schima, H., Laufer, G., Zimpfer, D. Tags: Cardiomyopathy, Heart Failure, Anticoagulants, Cardiovascular Surgery Original Articles Source Type: research
The Heavy Heart: Metabolic Mechanisms and Myocardial Mechanics [Editorials]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 11, 2017 Category: Cardiology Authors: Vest, A. R., Patel, A. R. Tags: Obesity, Metabolic Syndrome, Echocardiography Editorials Source Type: research
Cardiometabolic Traits and Systolic Mechanics in the Community [Original Articles]
Conclusions—
Our findings highlight the association of central obesity and related cardiometabolic phenotypes above and beyond body mass index with subclinical measures of LV mechanical function. Interestingly, obesity-related traits were associated with distinct aspects of LV mechanics, underscoring potential differential effects along specific LV planes of deformation. These findings may shed light onto obesity-related cardiac remodeling and heart failure. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 11, 2017 Category: Cardiology Authors: Ho, J. E., McCabe, E. L., Wang, T. J., Larson, M. G., Levy, D., Tsao, C., Aragam, J., Mitchell, G. F., Benjamin, E. J., Vasan, R. S., Cheng, S. Tags: Obesity, Metabolic Syndrome, Echocardiography Original Articles Source Type: research
Percutaneous Mitral Valve Edge-to-Edge Repair Assisted by Hemodynamic Support Devices: A Case Series of Bailout Procedures [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 10, 2017 Category: Cardiology Authors: Seizer, P., Schibilsky, D., Sauter, R., Schreieck, J., Lausberg, H., Walker, T., Gawaz, M., Langer, H. F., Schlensak, C. Tags: Heart Failure, Valvular Heart Disease, Catheter-Based Coronary and Valvular Interventions Images and Case Reports in Heart Failure Source Type: research
Closing the Care Gap: A Primer on Quality Improvement for Heart Failure Clinicians [Advances in Heart Failure]
Quality improvement (QI) initiatives have become an integral part of patient-centered care. In this primer, we outline 6 steps for initiating, implementing, and monitoring improvement in heart failure care. These steps include acknowledging that improvement is needed and setting a culture for improvement; forming a QI team; understanding the local problem; generating improvement strategies that will fit with the local problem; monitoring; testing; and refining improvements, analysis of data, and interpretation of run charts. This primer provides tools and resources for clinicians who want to learn how to perform QI specifi...
Source: Circulation: Heart Failure - May 10, 2017 Category: Cardiology Authors: Moayedi, Y., Schofield, T., Etchells, E., Silver, S. A., Kobulnik, J., McQuillan, R., Bell, C., Linghorne, M., Ross, H. J. Tags: Heart Failure, Quality and Outcomes Advances in Heart Failure Source Type: research
Stiff Left Atrial Syndrome After Multiple Percutaneous Catheter Ablations: Role for Invasive Hemodynamic Exercise Testing [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 9, 2017 Category: Cardiology Authors: Urey, M. A., Darden, D., Stoller, D., Drazner, M. H., Horn, V., Sarma, S., Levine, B. D. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Exercise Testing Images and Case Reports in Heart Failure Source Type: research
Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic {beta}-Adrenoceptor Blockade in Experimental and Human Heart Failure [Original Articles]
Conclusions—
Chronic β-AR blocker therapy in patients and in a mouse model of CaMKII-induced HF is not associated with a change in CaMKII activity. Thus, our data suggest that the molecular effects of β-AR blockers are not based on a modulation of CaMKII. Directly targeting CaMKII may, therefore, further improve HF therapy in addition to β-AR blockade. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 9, 2017 Category: Cardiology Authors: Dewenter, M., Neef, S., Vettel, C., Lammle, S., Beushausen, C., Zelarayan, L. C., Katz, S., von der Lieth, A., Meyer-Roxlau, S., Weber, S., Wieland, T., Sossalla, S., Backs, J., Brown, J. H., Maier, L. S., El-Armouche, A. Tags: Animal Models of Human Disease, Mechanisms, Heart Failure, Pharmacology Original Articles Source Type: research
INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design [Advances in Clinical Trials]
Approximately half of patients with heart failure have preserved ejection fraction. There is no proven treatment that improves outcome. The pathophysiology of heart failure with preserved ejection fraction is complex and includes left ventricular systolic and diastolic dysfunction, pulmonary vascular disease, endothelial dysfunction, and peripheral abnormalities. Multiple lines of evidence point to impaired nitric oxide (NO)-cGMP bioavailability as playing a central role in each of these abnormalities. In contrast to traditional organic nitrate therapies, an alternative strategy to restore NO-cGMP signaling is via inorgani...
Source: Circulation: Heart Failure - May 5, 2017 Category: Cardiology Authors: Reddy, Y. N. V., Lewis, G. D., Shah, S. J., LeWinter, M., Semigran, M., Davila-Roman, V. G., Anstrom, K., Hernandez, A., Braunwald, E., Redfield, M. M., Borlaug, B. A. Tags: Clinical Studies, Endothelium/Vascular Type/Nitric Oxide, Hemodynamics, Pathophysiology, Heart Failure Advances in Clinical Trials Source Type: research
Accuracy of Seattle Heart Failure Model and HeartMate II Risk Score in Non-Inotrope-Dependent Advanced Heart Failure Patients: Insights From the ROADMAP Study (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients) [Original Articles]
Conclusions—
In non–inotrope-dependent advanced heart failure patients receiving optimal medical management, the SHFM was predictive of overall survival but underestimated the risk of clinical worsening and LVAD implantation. Among LVAD patients, the HMRS had marginal discrimination and underestimated survival post–LVAD implantation.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01452802. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 2, 2017 Category: Cardiology Authors: Lanfear, D. E., Levy, W. C., Stehlik, J., Estep, J. D., Rogers, J. G., Shah, K. B., Boyle, A. J., Chuang, J., Farrar, D. J., Starling, R. C. Tags: Heart Failure, Cardiovascular Surgery, Mortality/Survival Original Articles Source Type: research
True Anemia-Red Blood Cell Volume Deficit-in Heart Failure: A Systematic Review [Original Articles]
Conclusions—
Presence or absence of true anemia in patients with HF as determined by RBCV status mainly concurs with diagnosis based on [Hb] and presents negative relationships with age, female sex, left ventricular ejection fraction, and body mass index. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 28, 2017 Category: Cardiology Authors: Montero, D., Lundby, C., Ruschitzka, F., Flammer, A. J. Tags: Biomarkers, Pathophysiology Original Articles Source Type: research
Multiphasic Regulation of Systemic and Peripheral Organ Metabolic Responses to Cardiac Hypertrophy [Original Article]
Conclusions—
Changes in insulin signaling, circulating natriuretic peptides and adipokines, and varied expression of adipose genes associated with altered insulin response/glucose handling and thermogenesis occurred prior to any functional decline in transverse aortic constriction hearts. The findings demonstrate multiphasic responses in extracardiac metabolism to pathogenic cardiac stress, with early iWAT browning providing potential metabolic benefits. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 12, 2017 Category: Cardiology Authors: Liew, C. W., Xu, S., Wang, X., McCann, M., Whang Kong, H., Carley, A. C., Pang, J., Fantuzzi, G., ODonnell, J. M., Lewandowski, E. D. Tags: Metabolism, Heart Failure, Hypertrophy, Metabolic Syndrome Original Article Source Type: research
Adenosine Formed by CD73 on T Cells Inhibits Cardiac Inflammation and Fibrosis and Preserves Contractile Function in Transverse Aortic Constriction-Induced Heart Failure [Original Article]
Conclusions—
Our data provide first evidence that CD73 on T cells plays an important anti-inflammatory role in TAC-induced heart failure, which is associated with antifibrotic activity and reduced production of proinflammatory cytokines most likely by activation of the adenosine A2a receptor. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 12, 2017 Category: Cardiology Authors: Quast, C., Alter, C., Ding, Z., Borg, N., Schrader, J. Tags: Basic Science Research, Inflammation, Heart Failure, Hypertrophy, Remodeling Original Article Source Type: research
Pericardiectomy to Treat Heart Failure With Preserved Ejection Fraction: Unrestrained Enthusiasm? [Editorials]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 10, 2017 Category: Cardiology Authors: LeWinter, M. M. Tags: Hemodynamics, Pathophysiology, Physiology, Heart Failure, Hypertrophy Editorials Source Type: research
Mechanism of Progressive Heart Failure and Significance of Pulmonary Hypertension in Obstructive Hypertrophic Cardiomyopathy [Original Articles]
Conclusions—
Pulmonary hypertension was common in obstructive hypertrophic cardiomyopathy patients with advanced heart failure. Although possibly a contributor to preoperative heart failure, pulmonary hypertension did not significantly influence clinical and surgical outcome. Notably, a novel patient subgroup was identified with resting invasive hemodynamics consistent with pulmonary vascular disease. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 10, 2017 Category: Cardiology Authors: Covella, M., Rowin, E. J., Hill, N. S., Preston, I. R., Milan, A., Opotowsky, A. R., Maron, B. J., Maron, M. S., Maron, B. A. Tags: Pathophysiology, Cardiomyopathy Original Articles Source Type: research
