Frequency of Poor Outcome (Death or Poor Quality of Life) After Left Ventricular Assist Device for Destination Therapy: Results From the INTERMACS Registry [Original Article]
Conclusions—
Nearly one third of patients die or have a persistently poor quality of life during the year after LVAD. We identified several factors associated with a poor outcome, which may inform discussions before LVAD implantation to enable more realistic expectations of recovery. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 8, 2016 Category: Cardiology Authors: Arnold, S. V., Jones, P. G., Allen, L. A., Cohen, D. J., Fendler, T. J., Holtz, J. E., Aggarwal, S., Spertus, J. A. Tags: Heart Failure, Quality and Outcomes Original Article Source Type: research
Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor [Original Article]
Conclusions—
Contractility is reduced via the EP3 receptor but increased via EP4. These effects may be mediated through changes in phospholamban phosphorylation and has relevance to detrimental effects of inflammation. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 7, 2016 Category: Cardiology Authors: Gu, X., Xu, J., Zhu, L., Bryson, T., Yang, X.-P., Peterson, E., Harding, P. Tags: Contractile Function, Growth Factors/Cytokines, Inflammation, Heart Failure Original Article Source Type: research
Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure [Original Article]
Conclusions—
Kindlin-2 is required to maintain integrin β1D protein stability. Postnatal loss of Kindlin-2 from cardiac myocytes leads to progressive heart failure, showing the importance of costameric proteins like Kindlin-2 for homeostasis of normal heart function. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 7, 2016 Category: Cardiology Authors: Zhang, Z., Mu, Y., Veevers, J., Peter, A. K., Manso, A. M., Bradford, W. H., Dalton, N. D., Peterson, K. L., Knowlton, K. U., Ross, R. S., Zhou, X., Chen, J. Tags: Heart Failure Original Article Source Type: research
Comprehensive Hemodynamic Assessment in a Single Echocardiography Still Frame [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 4, 2016 Category: Cardiology Authors: Niederseer, D., Frank, M., Tanner, F. C., Stampfli, S. F. Tags: Heart Failure, Echocardiography Images and Case Reports in Heart Failure Source Type: research
Glycogen Storage Disease Because of a PRKAG2 Mutation Causing Severe Biventricular Hypertrophy and High-Grade Atrio-Ventricular Block [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 4, 2016 Category: Cardiology Authors: Yogasundaram, H., Paterson, I. D., Graham, M., Sergi, C., Oudit, G. Y. Tags: Cardiomyopathy, Hypertrophy Images and Case Reports in Heart Failure Source Type: research
First Reported Case of MitraClip Placement Due to Mitral Valve Flail in the Setting of Cardiac Amyloidosis [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - August 2, 2016 Category: Cardiology Authors: Krishnaswamy, A., Hanna, M., Goodman, A., Kapadia, S. R. Tags: Valvular Heart Disease, Echocardiography, Catheter-Based Coronary and Valvular Interventions Images and Case Reports in Heart Failure Source Type: research
Targeting the Cardiac Myofibroblast Secretome to Treat Myocardial Fibrosis in Heart Failure [Development of Therapeutics for Heart Failure: Expedited Commentary]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 27, 2016 Category: Cardiology Authors: Weber, K. T., Diez, J. Tags: Heart Failure Development of Therapeutics for Heart Failure: Expedited Commentary Source Type: research
Variations on a Precision Medicine Theme: One Size Fits Some [Development of Therapeutics for Heart Failure: Expedited Commentary]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 27, 2016 Category: Cardiology Authors: Hauptman, P. J., Gong, T. A., Vidic, A. Tags: Heart Failure, Health Services Development of Therapeutics for Heart Failure: Expedited Commentary Source Type: research
Fluid Volume Overload and Congestion in Heart Failure: Time to Reconsider Pathophysiology and How Volume Is Assessed [Advances in Heart Failure]
Volume regulation, assessment, and management remain basic issues in patients with heart failure. The discussion presented here is directed at opening a reassessment of the pathophysiology of congestion in congestive heart failure and the methods by which we determine volume overload status. Peer-reviewed historical and contemporary literatures are reviewed. Volume overload and fluid congestion remain primary issues for patients with chronic heart failure. The pathophysiology is complex, and the simple concept of intravascular fluid accumulation is not adequate. The dynamics of interstitial and intravascular fluid compartm...
Source: Circulation: Heart Failure - July 18, 2016 Category: Cardiology Authors: Miller, W. L. Tags: Pathophysiology, Physiology, Heart Failure, Diagnostic Testing Advances in Heart Failure Source Type: research
Hashing It Out Over Cannabis: Moving Toward a Standard Guideline on Substance Use for Cardiac Transplantation Eligibility That Includes Marijuana [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2016 Category: Cardiology Authors: Allen, L. A., Ambardekar, A. V. Tags: Heart Failure, Transplantation Editorial Source Type: research
Heart Failure With a Better Ejection Fraction: Why Should We Care? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2016 Category: Cardiology Authors: Basuray, A., Fang, J. C. Tags: Cardiomyopathy, Heart Failure, Remodeling Editorial Source Type: research
Heart Failure, Diabetes Mellitus, and Chronic Kidney Disease: A Clinical Conundrum [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2016 Category: Cardiology Authors: Aguilar, D. Tags: Heart Failure Editorial Source Type: research
A Rare Pericardial Malignancy [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2016 Category: Cardiology Authors: Fatima, U., Gupta, S., Firchau, D. J., Stolpen, A. H., Sah, R. Tags: Heart Failure, Pericardial Disease Images and Case Reports in Heart Failure Source Type: research
Zooming in on the Microvasculature in Heart Failure With Preserved Ejection Fraction [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2016 Category: Cardiology Authors: Mohammed, S. F., Majure, D. T., Redfield, M. M. Tags: Heart Failure Editorial Source Type: research
Heart Failure With Improved Ejection Fraction: Clinical Characteristics, Correlates of Recovery, and Survival: Results From the Valsartan Heart Failure Trial [Original Article]
Conclusions—
Our data support HFiEF as a stratum of HF with reduced ejection fraction with a more favorable outcome, which occurs in a minority of patients with HF with reduced ejection fraction who have a lower prevalence of ischemic heart disease, a less severe hemodynamic, biomarker, and neurohormonal profile, and who are treated with a more intense HF medication regimen.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00336336. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2016 Category: Cardiology Authors: Florea, V. G., Rector, T. S., Anand, I. S., Cohn, J. N. Tags: Heart Failure, Remodeling Original Article Source Type: research
