Association Between Poorer Cognitive Function and Reduced Objectively Monitored Medication Adherence in Patients With Heart Failure [Original Articles]
Conclusions—
Poorer cognitive function, especially in regard to memory, predicted reduced medication adherence among patients with HF and no history of dementia. This effect remained after adjustment for factors known to predict adherence, such as depressed mood, social support, and disease severity level. Future studies should examine the link from cognitive impairment and medication nonadherence to clinical outcomes (eg, hospitalization and mortality).
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01461629. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 27, 2016 Category: Cardiology Authors: Dolansky, M. A., Hawkins, M. A. W., Schaefer, J. T., Sattar, A., Gunstad, J., Redle, J. D., Josephson, R., Moore, S. M., Hughes, J. W. Tags: Aging, Lifestyle, Secondary Prevention, Heart Failure, Treatment Original Articles Source Type: research
Constrictive Pericarditis and Protein-Losing Enteropathy: Is Extremely Severe Hypoalbuminemia Reversible by Pericardiectomy? [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 17, 2016 Category: Cardiology Authors: Moriyama, H., Kohno, T., Nishiyama, T., Hattori, O., Maekawa, Y., Yoshida, K., Murata, M., Okamoto, K., Sano, M., Shimizu, H., Fukuda, K. Tags: Heart Failure, Pericardial Disease Images and Case Reports in Heart Failure Source Type: research
Diagnosis of Left Ventricular Assist Device Outflow Graft Obstruction Using Intravascular Ultrasound [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 17, 2016 Category: Cardiology Authors: Muller Moran, H. R., Kass, M., Ravandi, A., Zieroth, S., Schaffer, S. A., Cordova, F. J., Pozeg, Z. I., Arora, R. C., Singal, R. K. Tags: Heart Failure, Ultrasound, Cardiovascular Surgery, Treatment, Complications Images and Case Reports in Heart Failure Source Type: research
Cobalt Cardiomyopathy: A Critical Reappraisal in Light of a Recent Resurgence [Advances in Heart Failure]
Cobalt can cause a distinctive, rapidly progressive and reversible depression of cardiac systolic function, which is readily distinguished from other causes of cardiomyopathy. Patients present with the subacute onset of severe heart failure, which is accompanied by hypotension and cyanosis, pericardial effusion, low voltage on the electrocardiogram, marked elevation of serum enzymes, and lactic acidosis. They typically have a history of lethargy, anorexia, and weight loss in the months preceding the illness and exhibit other evidence of cobalt’s effects on the body (eg, polycythemia and goiter). The course of cobalt-...
Source: Circulation: Heart Failure - November 14, 2016 Category: Cardiology Authors: Packer, M. Tags: Cardiomyopathy, Heart Failure Advances in Heart Failure Source Type: research
The Continuing Quest to Identify Ambulatory Patients With Advanced Heart Failure Who Benefit From Left Ventricular Assist Device Therapy [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 8, 2016 Category: Cardiology Authors: Wever-Pinzon, O., Drakos, S. G. Tags: Heart Failure Editorial Source Type: research
INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) Profiling Identifies Ambulatory Patients at High Risk on Medical Therapy After Hospitalizations for Heart Failure [Original Articles]
Conclusions—
Ambulatory patients with systolic HF, a heavy symptom burden, and at least 1 recent HF hospitalization are at high risk for death or left ventricular assist device rescue. INTERMACS profiles help identify ambulatory patients with advanced HF who may benefit from current mechanical support devices under existing indications. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 8, 2016 Category: Cardiology Authors: Stewart, G. C., Kittleson, M. M., Patel, P. C., Cowger, J. A., Patel, C. B., Mountis, M. M., Johnson, F. L., Guglin, M. E., Rame, J. E., Teuteberg, J. J., Stevenson, L. W. Tags: Heart Failure, Quality and Outcomes Original Articles Source Type: research
Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients [Original Articles]
Conclusions—
Higher concentration of sFlt1 with concomitant decreased circulating endothelial progenitor cell levels along with inappropriate attenuated vascular endothelial growth factor levels may imply an angiogenic imbalance that exists even after recovery and may thus predispose to PPCM. In addition, tissue Doppler imaging and 2D strain were able to identify residual myocardial injury in post-PPCM women with apparent recovery of LV systolic function. Both angiogenic imbalance and residual myocardial injury may play an important role in the recurrence of LV dysfunction during subsequent pregnancies. (Source: Circ...
Source: Circulation: Heart Failure - November 7, 2016 Category: Cardiology Authors: Goland, S., Weinstein, J. M., Zalik, A., Kuperstein, R., Zilberman, L., Shimoni, S., Arad, M., Ben Gal, T., George, J. Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Pregnancy, Cardiomyopathy, Echocardiography Original Articles Source Type: research
Reductions in N-Terminal Pro-Brain Natriuretic Peptide Levels Are Associated With Lower Mortality and Heart Failure Hospitalization Rates in Patients With Heart Failure With Mid-Range and Preserved Ejection Fraction [Original Articles]
Conclusions—
In HFmrEF and HFpEF during routine care, decreases in NT-proBNP were associated with improved mortality and morbidity. Studies to determine whether NT-proBNP changes in response to therapy predict drug efficacy are needed. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 7, 2016 Category: Cardiology Authors: Savarese, G., Hage, C., Orsini, N., Dahlstrom, U., Perrone-Filardi, P., Rosano, G. M. C., Lund, L. H. Tags: Biomarkers Original Articles Source Type: research
Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure [Original Articles]
Conclusions—
Patients with HF and SDB have more severe muscle vasoconstriction during hypoxia and hypercapnia than HF patients without SDB, which seems to be associated with endothelial dysfunction and, in part, increased MSNA response. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 7, 2016 Category: Cardiology Authors: Lobo, D. M. L., Trevizan, P. F., Toschi-Dias, E., Oliveira, P. A., Piveta, R. B., Almeida, D. R., Mady, C., Bocchi, E. A., Lorenzi-Filho, G., Middlekauff, H. R., Negrao, C. E. Tags: Heart Failure Original Articles Source Type: research
Hypoxia-Inducible Factor-1{alpha} Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-D-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure [Original Articles]
Conclusions—
These results uncover a critical role for HIF-1 in the upregulation of NMDA-NR1 to mediate sympathoexcitation in CHF. We conclude that subtle hypoxia within the PVN may act as a metabolic cue to modulate sympathoexcitation during CHF. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 2, 2016 Category: Cardiology Authors: Sharma, N. M., Cunningham, C. J., Zheng, H., Liu, X., Patel, K. P. Tags: Autonomic Nervous System, Basic Science Research, Mechanisms, Heart Failure Original Articles Source Type: research
Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction [Original Articles]
Conclusions—
These findings indicate that dual ET-A/ET-B receptor inhibition improves HFpEF by abrogating adverse cardiac remodeling via antihypertrophic mechanisms and by reducing stiffness. Additional studies are needed to explore the role of dual ET-1 receptor antagonists in patients with HFpEF. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 2, 2016 Category: Cardiology Authors: Valero-Munoz, M., Li, S., Wilson, R. M., Boldbaatar, B., Iglarz, M., Sam, F. Tags: Heart Failure, Hypertrophy, Remodeling Original Articles Source Type: research
First-in-Human Experience With Transcatheter Mitral Valve-in-Valve Implantation During Left Ventricular Assist Device Placement [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - November 1, 2016 Category: Cardiology Authors: Orasanu, G., Al-Kindi, S. G., Robinson, M. R., Oliveira, G. H., Ginwalla, M., Elamm, C., Zacharias, M., Farhoud, M., Medalion, B., Deo, S. V., Park, S. J., Attizzani, G. F., Sareyyupoglu, B. Tags: Heart Failure Images and Case Reports in Heart Failure Source Type: research
Variation in Hospital Use and Outcomes Associated With Pulmonary Artery Catheterization in Heart Failure in the United States [Original Articles]
Conclusions—
There is substantial hospital-level variability in PA catheterization in HF along with increasing volume at fewer hospitals over-represented by large, academic hospitals with advanced HF capabilities. This is accompanied by a decline in excess mortality associated with PA catheterization. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - October 24, 2016 Category: Cardiology Authors: Khera, R., Pandey, A., Kumar, N., Singh, R., Bano, S., Golwala, H., Kumbhani, D. J., Girotra, S., Fonarow, G. C. Tags: Hemodynamics, Heart Failure, Diagnostic Testing, Quality and Outcomes Original Articles Source Type: research
Impact of Statin Use After Heart Transplantation: A Meta-Analysis [Original Articles]
Conclusions—
The evidence from a pooled analysis suggests that statins improve survival in heart transplant recipients. Statins may prevent fatal rejection episodes, decrease terminal cancer risk, and reduce the incidence of coronary vasculopathy. Additional prospective studies are needed to further investigate and explain this association. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - October 10, 2016 Category: Cardiology Authors: Vallakati, A., Reddy, S., Dunlap, M. E., Taylor, D. O. Tags: Transplantation Original Articles Source Type: research
Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection Fraction [Original Articles]
Conclusions—
In early-stage hypertensive HFpEF, LA cardiomyocyte hypertrophy, titin hyperphosphorylation, and microvascular dysfunction occur in association with increased systolic and diastolic LA chamber stiffness, impaired atrioventricular coupling, and decreased left ventricular stroke volume. These data indicate that maladaptive LA remodeling occurs early during HFpEF development, supporting a concept of global myocardial remodeling. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - October 9, 2016 Category: Cardiology Authors: Zakeri, R., Moulay, G., Chai, Q., Ogut, O., Hussain, S., Takahama, H., Lu, T., Wang, X.-L., Linke, W. A., Lee, H.-C., Redfield, M. M. Tags: Animal Models of Human Disease, Hemodynamics, Heart Failure, Hypertension Original Articles Source Type: research
