Hypoxia-Inducible Factor-1{alpha} Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-D-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure [Original Articles]

Conclusions— These results uncover a critical role for HIF-1 in the upregulation of NMDA-NR1 to mediate sympathoexcitation in CHF. We conclude that subtle hypoxia within the PVN may act as a metabolic cue to modulate sympathoexcitation during CHF.
Source: Circulation: Heart Failure - Category: Cardiology Authors: Tags: Autonomic Nervous System, Basic Science Research, Mechanisms, Heart Failure Original Articles Source Type: research