Hypoxia-Inducible Factor-1{alpha} Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl-D-Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure [Original Articles]
Conclusions—
These results uncover a critical role for HIF-1 in the upregulation of NMDA-NR1 to mediate sympathoexcitation in CHF. We conclude that subtle hypoxia within the PVN may act as a metabolic cue to modulate sympathoexcitation during CHF.
Source: Circulation: Heart Failure - Category: Cardiology Authors: Sharma, N. M., Cunningham, C. J., Zheng, H., Liu, X., Patel, K. P. Tags: Autonomic Nervous System, Basic Science Research, Mechanisms, Heart Failure Original Articles Source Type: research
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