Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection Fraction [Original Articles]

Conclusions—
In early-stage hypertensive HFpEF, LA cardiomyocyte hypertrophy, titin hyperphosphorylation, and microvascular dysfunction occur in association with increased systolic and diastolic LA chamber stiffness, impaired atrioventricular coupling, and decreased left ventricular stroke volume. These data indicate that maladaptive LA remodeling occurs early during HFpEF development, supporting a concept of global myocardial remodeling.

Source: Circulation: Heart Failure - October 9, 2016 Category: Cardiology Authors: Zakeri, R., Moulay, G., Chai, Q., Ogut, O., Hussain, S., Takahama, H., Lu, T., Wang, X.-L., Linke, W. A., Lee, H.-C., Redfield, M. M. Tags: Animal Models of Human Disease, Hemodynamics, Heart Failure, Hypertension Original Articles Source Type: research