Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure [Original Article]

Conclusions— Kindlin-2 is required to maintain integrin β1D protein stability. Postnatal loss of Kindlin-2 from cardiac myocytes leads to progressive heart failure, showing the importance of costameric proteins like Kindlin-2 for homeostasis of normal heart function.

http://circheartfailure.ahajournals.org/cgi/content/short/9/8/e003129?rss=1

Source: Circulation: Heart Failure - August 7, 2016 Category: Cardiology Authors: Zhang, Z., Mu, Y., Veevers, J., Peter, A. K., Manso, A. M., Bradford, W. H., Dalton, N. D., Peterson, K. L., Knowlton, K. U., Ross, R. S., Zhou, X., Chen, J. Tags: Heart Failure Original Article Source Type: research