Multiphasic Regulation of Systemic and Peripheral Organ Metabolic Responses to Cardiac Hypertrophy [Original Article]

Conclusions—
Changes in insulin signaling, circulating natriuretic peptides and adipokines, and varied expression of adipose genes associated with altered insulin response/glucose handling and thermogenesis occurred prior to any functional decline in transverse aortic constriction hearts. The findings demonstrate multiphasic responses in extracardiac metabolism to pathogenic cardiac stress, with early iWAT browning providing potential metabolic benefits.

Source: Circulation: Heart Failure - April 12, 2017 Category: Cardiology Authors: Liew, C. W., Xu, S., Wang, X., McCann, M., Whang Kong, H., Carley, A. C., Pang, J., Fantuzzi, G., ODonnell, J. M., Lewandowski, E. D. Tags: Metabolism, Heart Failure, Hypertrophy, Metabolic Syndrome Original Article Source Type: research