Implications of Using Different Definitions on Outcomes in Worsening Heart Failure [Original Article]

Conclusions— A WHF definition that excluded the intensification of diuretics resulted in a lower event rate but a stronger association with outcomes. These data support the need for continued efforts to standardize WHF definitions in clinical trials. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00577135 (DOSE) and NCT01132846 (ROSE).

http://circheartfailure.ahajournals.org/cgi/content/short/9/8/e003048?rss=1

Source: Circulation: Heart Failure - August 10, 2016 Category: Cardiology Authors: Kelly, J. P., Cooper, L. B., Gallup, D., Anstrom, K. J., Chen, H. H., Redfield, M. M., OConnor, C. M., Mentz, R. J., Hernanadez, A. F., Felker, G. M. Tags: Heart Failure Original Article Source Type: research