Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines? [Original Article]

Conclusions— Our findings suggest, for the first time, that skeletal muscle alterations are exacerbated in HFrEF compared with HFpEF, which predominantly reside in limb, rather than in respiratory, muscle. This disparity may be mediated, in part, by the different circulating inflammatory cytokines that were elevated between HFpEF and HFrEF.

http://circheartfailure.ahajournals.org/cgi/content/short/9/9/e003027?rss=1

Source: Circulation: Heart Failure - September 7, 2016 Category: Cardiology Authors: Seiler, M., Bowen, T. S., Rolim, N., Dieterlen, M.-T., Werner, S., Hoshi, T., Fischer, T., Mangner, N., Linke, A., Schuler, G., Halle, M., Wisloff, U., Adams, V. Tags: Basic Science Research, Growth Factors/Cytokines, Oxidant Stress, Pathophysiology, Heart Failure Original Article Source Type: research