Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights [Original Article]

Conclusions— Hypochloremia is associated with neurohormonal activation and diuretic resistance with chloride depletion as a candidate mechanism. Sodium-free chloride supplementation was associated with increases in serum chloride and changes in several cardiorenal parameters. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02031354.

http://circheartfailure.ahajournals.org/cgi/content/short/9/8/e003180?rss=1

Source: Circulation: Heart Failure - August 8, 2016 Category: Cardiology Authors: Hanberg, J. S., Rao, V., ter Maaten, J. M., Laur, O., Brisco, M. A., Perry Wilson, F., Grodin, J. L., Assefa, M., Samuel Broughton, J., Planavsky, N. J., Ahmad, T., Bellumkonda, L., Wilson Tang, W. H., Parikh, C. R., Testani, J. M. Tags: Cardiorenal Syndrome, Heart Failure Original Article Source Type: research