Gender ‐related differences in antiplatelet treatment patterns and outcome: Insights from the GReekAntiPlatElet Registry
ConclusionsIn a contemporary “real‐life” cohort of patients with ACS treated with PCI and focusing on antiplatelet treatment 1‐year ischemic outcome does not differ by gender, while women do present more frequently not actionable bleeding events. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - July 14, 2017 Category: Cardiology Authors: Ioanna Xanthopoulou, Periklis Davlouros, Spyridon Deftereos, Michalis Hamilos, George Sitafidis, Ioannis Kanakakis, Manolis Vavouranakis, John Goudevenos, John Lekakis, Dimitrios Alexopoulos Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Ivabradine vs metoprolol in patients with acute inferior wall myocardial infarction —“Expanding arena for ivabradine”
ConclusionsIvabradine is well tolerated and equally effective as metoprolol in acute inferior wall ST elevation myocardial infarction patients for lowering the heart rate with lesser risk of AV blocks. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - July 14, 2017 Category: Cardiology Authors: Kumari Priti, Bhanwar L. Ranwa, Rajendra K. Gokhroo, Kamal Kishore, Devendra Singh Bisht, Sajal Gupta Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Pulmonary vein isolation with concomitant renal artery denervation is associated with reduction in both arterial blood pressure and atrial fibrillation burden: Data from implantable cardiac monitor
ConclusionsRenal artery denervation when added to PVI decreases AF recurrences, AF burden, and mean BP. Reduction in mean BP is associated with both AF burden and recurrences. Further large‐scale studies are needed to define the mechanistic pathway(s) of the antiarrhythmic effects of RDN. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - July 14, 2017 Category: Cardiology Authors: Alexander Romanov, Evgeny Pokushalov, Dmitry Ponomarev, Artem Strelnikov, Vitaliy Shabanov, Denis Losik, Alexander Karaskov, Jonathan S. Steinberg Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Effects of clopidogrel on inflammatory cytokines and adhesion molecules in human endothelial cells: Role of nitric oxide mediating pleiotropic effects
ConclusionsOur results support new evidence for pleiotropic effects of clopidogrel on inflammation and endothelial function. Reduction in ICAM‐1 and MCP‐1 in human endothelium is an important extent of the use of this drug for treatment of cardiovascular diseases, and NO has an important role in this process. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - July 14, 2017 Category: Cardiology Authors: Alvaro Cerda, Monica Pavez, Victor Manriquez, Andre Ducati Luchessi, Pamela Leal, Felipe Benavente, Cristina Moreno Fajardo, Luis Salazar, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Issue Information
(Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - July 14, 2017 Category: Cardiology Tags: ISSUE INFORMATION Source Type: research
Pitavastatin Up ‐regulate eNOS production by Suppressing miR‐155 Expression in Lipopolysaccharide‐Stimulated Human Umbilical Vein Endothelial Cells
ConclusionPitavastatin increases eNOS expression and inhibits of LPS‐induced miR‐155 expression.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 30, 2017 Category: Cardiology Authors: Changqin Jing, Menglong Guo, Xiaodan Bao, Tianhan Li, Juntang Lin, Xinjie Lu, Wenfeng Wang Tags: Original Research Article Source Type: research
Comparative evaluation of torasemide and spironolactone on adverse cardiac remodeling in a rat model of dilated cardiomyopathy
ConclusionTorasemide treatment has benefits against adverse cardiac remodeling in CHF rats, which was better than the protection offered by spironolactone.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 30, 2017 Category: Cardiology Authors: Somasundaram Arumugam, Remya Sreedhar, Vengadeshprabhu Karuppagounder, Meilei Harima, Masahiko Nakamura, Hiroshi Suzuki, Hirohito Sone, Kenichi Watanabe Tags: Original Research Article Source Type: research
MiR ‐195 Promotes Abdominal Aortic Aneurysm Media Remodeling by Targeting Smad3
ConclusionMiR‐195 promotes media remodeling by targeting Smad3 in AAA progression. This study suggests that miR‐195 contributes to the pathogenesis of AAA and reveals a new targeted therapy strategy for AAA patients.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 30, 2017 Category: Cardiology Authors: Bing Liang, Jianbo Che, Hui Zhao, Zhi Zhang, Gongning Shi Tags: Original Research Article Source Type: research
Pioglitazone attenuates atrial remodeling and vulnerability to atrial fibrillation in alloxan ‐induced diabetic rabbits
ConclusionPioglitazone attenuates diabetes‐induced structural and electrophysiological remodeling in the atria, thereby reducing the vulnerability to AF.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 30, 2017 Category: Cardiology Authors: Changle Liu, Ruimeng Liu, Huaying Fu, Jian Li, Xinghua Wang, Lijun Cheng, Panagiotis Korantzopoulos, Gary Tse, Guangping Li, Tong Liu Tags: Original Research Article Source Type: research
Impact on Survival of Warfarin in Patients with Pulmonary Arterial Hypertension Receiving Subcutaneous Treprostinil
ConclusionsLong‐term anticoagulation with warfarin was not associated with any significant effect on survival in PAH or idiopathic PAH patients treated with SQ treprostinil.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 23, 2017 Category: Cardiology Authors: Mona Ascha, Xuan Zhou, Youlan Rao, Omar A. Minai, Adriano R. Tonelli Tags: Original Research Article Source Type: research
Critical role of TNF inhibition in combination therapy for elderly mice with atherosclerosis
This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 23, 2017 Category: Cardiology Authors: Kyung ‐Yeon Park, Tae‐Hwe Heo Tags: Original Research Article Source Type: research
Pharmacokinetics, Pharmacodynamics of Bococizumab, a monoclonal antibody to PCSK9, After Single Subcutaneous Injection at 3 Sites [NCT 02043301]
ConclusionsSimilar PK profiles and robust LDL‐C reductions were observed following single 150‐mg s.c. injections of bococizumab administered to the abdomen, thigh, or upper arm in untreated subjects with LDL‐C ≥130 mg/dL. Bococizumab was generally well‐tolerated following a single 150‐mg s.c. administration in this subject population.ClinicalTrials. gov identifier: NCT02043301 (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 21, 2017 Category: Cardiology Authors: Ellen Q. Wang, Anna Plotka, Joanne Salageanu, Catherine Sattler, Carla Yunis Tags: Original Research Article Source Type: research
Inhibition of mevalonate pathway prevents ischemia ‐induced cardiac dysfunction in rats via RhoA‐independent signaling pathway
ConclusionsThe present findings indicate that mevalonate pathway inhibition by rosuvastatin and alendronate prevent cardiac remodeling and dysfunction possibly through RhoA‐independent mechanisms.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 1, 2017 Category: Cardiology Authors: Ying Yang, Xiqing Rong, Xue Lv, Wenbing Jiang, Yuan Yang, Dongwu Lai, Shiming Xu, Guosheng Fu Tags: Original Research Article Source Type: research
Post conditioning with Metformin attenuates apoptotic events in cardiomyoblasts associated with ischemic reperfusion injury
This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 1, 2017 Category: Cardiology Authors: Rajesh Ramachandran, Mini S Tags: Original Research Article Source Type: research
Sulforaphane Protection against the Development of Doxorubicin ‐Induced Chronic Heart Failure is associated with Nrf2 Upregulation
ConclusionWe arrived at the conclusion that DOX‐induced CHF can be prevented by SFN through the upregulation of Nrf2 expression and transcriptional function.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - June 1, 2017 Category: Cardiology Authors: Yang Bai, Qiang Chen, Yun ‐Peng Sun, Xuan Wang, Li Lv, Li‐Ping Zhang, Jin‐Sha Liu, Song Zhao, Xiao‐Lu Wang Tags: Original Research Article Source Type: research
