Onset ‐to‐device time of patients who arrive at off‐hours: Importance of prehospital management and public awareness for patients with ST‐segment elevation myocardial infarction
ConclusionsThe OTD time might be markedly longer in STEMI patients who arrive at the hospital during on‐hours than in those who arrive at the hospital during off‐hours because of the underuse of emergency medical services at STEMI onset. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 11, 2016 Category: Cardiology Authors: Yukio Mizuguchi, Hiroki Shibutani, Sho Hashimoto, Takeshi Yamada, Norimasa Taniguchi, Shunsuke Nakajima, Tetsuya Hata, Akihiko Takahashi Tags: Original Research Article Source Type: research
Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction
ConclusionsHumanin analogue pretreatment exerted cardioprotective effects against I/R injury through the attenuation of cardiac mitochondrial dysfunction. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 11, 2016 Category: Cardiology Authors: Savitree Thummasorn, Nattayaporn Apaijai, Sasiwan Kerdphoo, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn Tags: Original Research Article Source Type: research
Preprocedural but not periprocedural high ‐sensitive Troponin T levels predict outcome in patients undergoing transcatheter aortic valve implantation
ConclusionElevated preprocedural hsTNT represents an independent risk predictor of all‐cause death while periprocedural hsTNT elevation failed to show prognostic relevance. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 11, 2016 Category: Cardiology Authors: Wiebke M. K öhler, Sandra Freitag‐Wolf, Moritz Lambers, Matthias Lutz, Philip Maximilian Niemann, Rainer Petzina, Georg Lutter, Peter Bramlage, Norbert Frey, Derk Frank Tags: Original Research Article Source Type: research
Issue Information
(Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - November 11, 2016 Category: Cardiology Tags: Issue Information Source Type: research
Salidroside Protects against Homocysteine ‐induced Injury in HUVECs via The Regulation of Endoplasmic Reticulum Stress
ConclusionsTaken together, these findings implicate that SAL could regulate ER‐stress pathway on the viability of endotheliocyte induced by Hcy in vitro. Our findings provide the first evidence that SAL plays an important role in endotheliocyte protection via suppressing ER‐stress pathway in HUVEC cells, and that it may be a promising therapeutic target for atherosclerosis and cardiovascular disease.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 30, 2016 Category: Cardiology Authors: Lin Zhu, Fang Jia, Jiang Wei, Yang Yu, Tianhong Yu, Yanjun Wang, Jianhui Sun, Guanghua Luo Tags: Original Research Article Source Type: research
Platelet Activating Factor (PAF): A potential biomarker in Acute Coronary Syndrome?
This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 30, 2016 Category: Cardiology Authors: P R Anand Vijaya Kumar, Treesa P. Varghese, Sreedevi Vanapalli, N K Nair, Menge Denis Mingate Tags: Commissioned Article Review Source Type: research
A U ‐Shaped Association of Body Mass Index (BMI) and All‐cause Mortality in Heart Failure Patients: A Dose‐response Meta‐analysis of Prospective Cohort Studies
ConclusionHF patients with higher BMI (>28kg/m2) have a better survival, whereas underweight and those with severe obesity (e.g. BMI >37 kg/m2) have a higher mortality.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 30, 2016 Category: Cardiology Authors: Wei Qin, Feng Liu, Chen Wan Tags: Original Research Article Source Type: research
Serelaxin in Acute Heart Failure: Most Recent Update on Clinical and Preclinical Evidence
This article summarizes the most updated published preclinical and clinical study data on serelaxin, including pharmacokinetic, pharmacodynamic, safety studies in hepatic, renal impaired patients, phase II and phase III trials.
This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 30, 2016 Category: Cardiology Authors: Raktim Kumar Ghosh, Kinjal Banerjee, Ramyashree Tummala, Somedeb Ball, Keyvan Ravakhah, Anjan Gupta Tags: Commissioned Article (Review) Source Type: research
Adenosine triphosphate postconditioning is associated with better preserved global and regional cardiac function during myocardial ischemia and reperfusion: a speckle tracking imaging ‐based echocardiologic study
ConclusionsIPostC and ATP‐PPostC may exert cardioprotective functions by better preservation of cardiac function during the I/R process and at least partly via attenuation of myocardial apoptosis. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 27, 2016 Category: Cardiology Authors: Min Ren, Yujie Liu, Huiya Zhao, Shixia Dong, Zhonghui Jiang, Keting Li, Jiawei Tian Tags: Original Research Article Source Type: research
Oral administration of recombinant Mycobacterium smegmatis expressing a tripeptide construct derived from endogenous and microbial antigens prevents atherosclerosis in ApoE −/− mice
ConclusionsOur results suggest that M. smegmatis can be developed as an oral carrier of recombinant proteins to treat inflammatory autoimmune diseases. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 27, 2016 Category: Cardiology Authors: Vrushali Deshpande, Rameshkumar Krishnan, Sheena Philip, Ildiko Faludi, Thiruvelselvan Ponnusamy, Lakshmi Narasimha Rao Thota, Valeria Endresz, Xinjie Lu, Vijay V. Kakkar, Lakshmi A. Mundkur Tags: Original Research Article Source Type: research
Issue Information
(Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 27, 2016 Category: Cardiology Tags: Issue Information Source Type: research
Impact of stent diameter and length on in ‐stent restenosis after DES vs BMS implantation in patients needing large coronary stents – a clinical and health‐economic evaluation
ConclusionIn the BASKET‐PROVE study population, the strongest predictor of ISR is the use of a BMS, even in patients in need of stents ≥3.0mm and ≤15mm lesion length and DES were cost‐effective. This should prompt the NICE to reevaluate its recommendation to use DES instead of BMS only in vessels <3.0mm and lesions >15mm length.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 22, 2016 Category: Cardiology Authors: Rainer Zbinden, Stefanie von Felten, Bastian Wein, David Tueller, David J Kurz, Ivano Reho, Soren Galatius, Hannes Alber, David Conen, Matthias Pfisterer, Christoph Kaiser, Franz R Eberli Tags: Original Research Article Source Type: research
Cytochrome P450 2C9 gene polymorphism and warfarin maintenance dosage in pediatric patients: A systematic review and meta ‐analysis
ConclusionsWe found that CYP2C9 gene polymorphism(referring to the presence of *1/*2, *1/*3, and variant genotypes in the population in addition to the wild type) was significantly associated with decreased warfarin maintenance dose requirements. Additionally, a specific indication for warfarin, the Fontan procedure, was associated with a lower daily warfarin dose. However, the results of our study require confirmation from more research with larger numbers of pediatric patients.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - September 22, 2016 Category: Cardiology Authors: Jinhua Zhang, Lihong Tian, Jinlong Huang, Sihan Huang, Tingting Chai, Jianzhen Shen Tags: Original Research Article Source Type: research
Colchicine for prevention and treatment of cardiac diseases: a meta ‐analysis
ConclusionColchicine appears to be efficacious and well tolerated for recurrent pericarditis/post‐pericardiotomy syndrome and recurrence of post procedural atrial fibrillation. However, its efficacy may be limited by its gastrointestinal adverse events and treatment discontinuation rates particularly in post‐operative patients.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - August 30, 2016 Category: Cardiology Authors: Nikos Papageorgiou, Alexandros Briasoulis, George Lazaros, Massimo Imazio, Dimitris Tousoulis Tags: Original Research Article Source Type: research
Warfarin persistence among atrial fibrillation patients – why is treatment ended?
ConclusionsAlthough persistence to warfarin among AF patients proves higher than previously reported, there is room for improvement since half of the discontinuers have questionable reasons for treatment stop and the majority of them receive no other efficient stroke prophylaxis.This article is protected by copyright. All rights reserved. (Source: Cardiovascular Therapeutics)
Source: Cardiovascular Therapeutics - August 26, 2016 Category: Cardiology Authors: Fredrik Bj örck, E k Agnes, Lars Johansson, Anders Själander Tags: Original Research Article Source Type: research
