Correlation between expressions of Cyclin-D1, EGFR and p53 with chemoradiation response in patients of locally advanced oral squamous cell carcinoma
Conclusion Expressions and coexpressions of Cyclin-D1 and p53 may serve as a prognostic marker in OSCC patients. (Source: BBA Clinical)
Source: BBA Clinical - November 28, 2014 Category: Biochemistry Source Type: research
Correlation between expression of Cyclin-D1, EGFR and p53 with chemoradiation response in patients of locally advanced oral squamous cell carcinoma
Conclusion Expressions and co expressions of Cyclin-D1 and p53 may serve as a prognostic marker in OSCC patients. (Source: BBA Clinical)
Source: BBA Clinical - November 22, 2014 Category: Biochemistry Source Type: research
A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population
Conclusions and general significance Since the optimized PFRM consistently outperformed BCRAT in all Caucasian study populations, it represents an improved personalized risk assessment tool. The finding of higher Marin County risk linked to a CYP11B2 aldosterone synthase SNP associated with essential hypertension offers a new genetic clue to sporadic breast cancer predisposition. (Source: BBA Clinical)
Source: BBA Clinical - November 13, 2014 Category: Biochemistry Source Type: research
The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation
Conclusions We interpret the elevated thyroid vascularization and low magnesium levels as signs of an inflammatory process related to the musculoskeletal changes. Improvement of thyroid function and morphology can be achieved after correcting the influence of stressors together with the supplementation regime. We hypothesize that the central biochemical event in thyroid disease is that of an acquired, altered mitochondrial function due to deficiency of magnesium, selenium, and coenzyme Q10. Graphical abstract (Source: BBA Clinical)
Source: BBA Clinical - November 12, 2014 Category: Biochemistry Source Type: research
O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
Conclusions Our results provide strong support for the hypotheses that MGMT activity promotes alkylator resistance and reflects promoter methylation status in malignant gliomas. General significance MGMT activity is an attractive target for anti-resistance therapy regardless of methylation status. (Source: BBA Clinical)
Source: BBA Clinical - November 11, 2014 Category: Biochemistry Source Type: research
Steroid Metabolizing Gene Variant in Polyfactorial Model Improves Risk Prediction in A High Incidence Breast Cancer Population
Conclusions and General Significance Since the optimized PFRM consistently outperformed BCRAT in all Caucasian study populations, it represents an improved personalized risk assessment tool. The finding of higher Marin County risk linked to a CYP11B2 aldosterone synthase SNP associated with essential hypertension offers a new genetic clue to sporadic breast cancer predisposition. (Source: BBA Clinical)
Source: BBA Clinical - November 8, 2014 Category: Biochemistry Source Type: research
Positivity of both plasma Epstein–Barr virus DNA and serum Epstein–Barr virus capsid specific immunoglobulin A is a better prognostic biomarker for nasopharyngeal carcinoma
Conclusion These data indicated that positivity for both EBV-DNA and VCA-IgA was a better biomarker for the prognosis of patients with NPC. Our findings may provide new references for clinical practice. (Source: BBA Clinical)
Source: BBA Clinical - November 7, 2014 Category: Biochemistry Source Type: research
Enumeration of circulating fibrocytes for clinical use in asthma by an optimized single-platform flow cytometry assay
Conclusions The novel assay for the enumeration of fibrocytes in the whole blood is reliable and clinically applicable. General significance This report demonstrates the validity and reliability of the first optimized assay for the enumeration of circulating fibrocytes in multicenter clinical trials. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Cerebrospinal fluid inflammatory markers in patients with Listeria monocytogenes meningitis
Conclusions Our data suggest that T-cell activation, complement activation, interferon- and endothelial growth factor production are important in the immune response to Listeria meningitis, and thereby influence outcome. General significance Our study provides target pathways for further studies in the pathophysiology of Listeria meningitis. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Mutation of EMG1 causing Bowen–Conradi syndrome results in reduced cell proliferation rates concomitant with G2/M arrest and 18S rRNA processing delay
Publication date: June 2014 Source:BBA Clinical, Volume 1 Author(s): Joy Armistead , Richard Hemming , Nehal Patel , Barbara Triggs-Raine Bowen–Conradi syndrome (BCS) is a lethal autosomal recessive disorder caused by a D86G substitution in the protein, Essential for Mitotic Growth 1 (EMG1). EMG1 is essential for 18S rRNA maturation and 40S ribosome biogenesis in yeast, but no studies of its role in ribosome biogenesis have been done in mammals. To assess the effect of the EMG1 mutation on cell growth and ribosomal biogenesis in humans, we employed BCS patient cells. The D86G substitution did not interfere with E...
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Screening of a healthy newborn identifies three adult family members with symptomatic glutaric aciduria type I
We report three adult sibs (one female, two males) with symptomatic glutaric acidura type I, who were diagnosed after a low carnitine level was found by newborn screening in a healthy newborn of the women. All three adults had low plasma carnitine, elevated glutaric acid levels and pronounced 3-hydroxyglutaric aciduria. The diagnosis was confirmed by undetectable glutaryl-CoA dehydrogenase activity in lymphocytes and two pathogenic heterozygous mutations in the GCDH gene (c.1060A>G, c.1154C>T). These results reinforce the notion that abnormal metabolite levels in newborns may lead to the diagnosis of adult me...
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Nerve growth factor and its receptor in schizophrenia
In conclusion, our results demonstrate association of schizophrenia with the rs6330, rs4839435 and rs734194, rs11466155, rs2072446 as well as with the decreased blood levels of corresponding proteins. Our findings indicate the implication of alterations in NGFR and NGFR genes in schizophrenia, particularly, in defects of synaptic plasticity. Furthermore, the data obtained suggests that at least in Armenian population the NGF rs6330*T and NGFR rs11466155*T, rs2072446*T alleles might be nominated as risk factors, whereas the NGF rs4839435*A and NGFR rs734194*G alleles might be protective against developing schizophrenia. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Cells from the skin of patients with systemic sclerosis secrete chitinase 3-like protein 1
Conclusions The emergence of cells primed to respond to OSM with increased Chi3L1 production appears to be associated with pathological processes active in SSc. General significance The presence of progenitor cells expressing the chilectin Chi3L1 in SSc skin appears to play a role in the initiation of the disease process. Graphical abstract (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Molecular profiling of childhood cancer: Biomarkers and novel therapies
Publication date: June 2014 Source:BBA Clinical, Volume 1 Author(s): Federica Saletta , Carol Wadham , David S. Ziegler , Glenn M. Marshall , Michelle Haber , Geoffrey McCowage , Murray D. Norris , Jennifer A. Byrne Background Technological advances including high-throughput sequencing have identified numerous tumor-specific genetic changes in pediatric and adolescent cancers that can be exploited as targets for novel therapies. Scope of review This review provides a detailed overview of recent advances in the application of target-specific therapies for childhood cancers, either as single agents or in combin...
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Association of mitochondrial dysfunction and fatigue: A review of the literature
Publication date: June 2014 Source:BBA Clinical, Volume 1 Author(s): Kristin Filler , Debra Lyon , James Bennett , Nancy McCain , Ronald Elswick , Nada Lukkahatai , Leorey N. Saligan Fatigue is often described by patients as a lack of energy, mental or physical tiredness, diminished endurance, and prolonged recovery after physical activity. Etiologic mechanisms underlying fatigue are not well understood; however, fatigue is a hallmark symptom of mitochondrial disease, making mitochondrial dysfunction a putative biological mechanism for fatigue. Therefore, this review examined studies that investigated the associ...
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
