Molecular profiling of childhood cancer: Biomarkers and novel therapies

Publication date: June 2014 Source:BBA Clinical, Volume 1 Author(s): Federica Saletta , Carol Wadham , David S. Ziegler , Glenn M. Marshall , Michelle Haber , Geoffrey McCowage , Murray D. Norris , Jennifer A. Byrne Background Technological advances including high-throughput sequencing have identified numerous tumor-specific genetic changes in pediatric and adolescent cancers that can be exploited as targets for novel therapies. Scope of review This review provides a detailed overview of recent advances in the application of target-specific therapies for childhood cancers, either as single agents or in combination with other therapies. The review summarizes preclinical evidence on which clinical trials are based, early phase clinical trial results, and the incorporation of predictive biomarkers into clinical practice, according to cancer type. Major conclusions There is growing evidence that molecularly targeted therapies can valuably add to the arsenal available for treating childhood cancers, particularly when used in combination with other therapies. Nonetheless the introduction of molecularly targeted agents into practice remains challenging, due to the use of unselected populations in some clinical trials, inadequate methods to evaluate efficacy, and the need for improved preclinical models to both evaluate dosing and safety of combination therapies. General significance The increasing recognition of the heterogeneity of molecular causes of cancer favor...
Source: BBA Clinical - Category: Biochemistry Source Type: research