Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects
Conclusions As far as we know, this is the first report which could demonstrate the impact of blood transaminase levels on blood glutamate concentration and memory functions in human. These findings are important for the interpretation of obesity-induced metabolic syndrome with elevated transaminases and cognitive dysfunction. Graphical abstract (Source: BBA Clinical)
Source: BBA Clinical - February 24, 2016 Category: Biochemistry Source Type: research
Reduced Inflammatory and Muscle Damage Biomarkers following Oral Supplementation with Bioavailable Curcumin
Conclusions Collectively, the findings demonstrated that consumption of curcumin reduced biological inflammation, but not quadriceps muscle soreness, during recovery after EIMD. The observed improvements in biological inflammation may translate to faster recovery and improved functional capacity during subsequent exercise sessions. General Significance These findings support the use of oral curcumin supplementation to reduce the symptoms of EIMD. The next logical step is to evaluate this further the efficacy of in an inflammatory clinical disease model. (Source: BBA Clinical)
Source: BBA Clinical - February 20, 2016 Category: Biochemistry Source Type: research
Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and Henoch-Schönlein purpura nephritis
Conclusions Determination of CD89 and TG2 in urine samples can be useful to identify patients with active IgAN/HSPN. (Source: BBA Clinical)
Source: BBA Clinical - February 17, 2016 Category: Biochemistry Source Type: research
Up-regulation of the human-specific CHRFAM7A gene in inflammatory bowel disease
Conclusion: The human-specific CHRFAM7A gene is up-regulated, and its target, CHRNA7, down-regulated, in IBD. Differences between ulcerative colitis and Crohn's disease tie to location of disease. Significance: The appearance of IBD in modern humans may be consequent to the emergence of CHRFAM7A, a human-specific α7-nAChR antagonist. CHRFAM7A could present a new, unrecognized target for development of IBD therapeutics. (Source: BBA Clinical)
Source: BBA Clinical - February 9, 2016 Category: Biochemistry Source Type: research
Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese
Conclusions Hepatic lipid parameters in MO patients change based on their comorbidities. The gene expression and lipid levels after bariatric surgery were less prominent in the diabetic patients. Lipid receptor overexpression could enable the liver to capture circulating lipids, thus favouring the steatosis typically observed in diabetic and dyslipidaemic MO individuals. (Source: BBA Clinical)
Source: BBA Clinical - February 9, 2016 Category: Biochemistry Source Type: research
Involvement of mirror neuron system in prodromal Alzheimer's disease
Conclusions High EEG alpha3/alpha2 frequency power ratio was associated with atrophy of IPL areas in MCI subjects. General significance The scientific hypothesis is divided into the following main points: 1) the theoretical background considering two recent theories, an evolutionary perspective theory and the theory of mind (ToM), which both track a possible relationship between prodromal AD and mirror system; 2) the relationship has been focused on the prodromal stage of Alzheimer's disease, that is a peculiar and very debated phase of the disease itself; and 3) not a generical relationship, but a focused anatomo-functi...
Source: BBA Clinical - February 9, 2016 Category: Biochemistry Source Type: research
Analysis of single nucleotide polymorphisms implicate mTOR signalling in the development of new-onset diabetes after transplantation
Conclusion This study represents a replication study of candidate SNPs associated with developing NODAT and implicates mTOR as the central regulator via altered insulin sensitivity, pancreatic β cell, and mitochondrial survival and dysfunction as evidenced by the five SNPs. General significance 1) Highlights the importance of careful biochemical phenotyping with oral glucose tolerance tests to diagnose NODAT in reducing time to diagnosis and missed cases. 2) This alters potential genotype:phenotype association. 3) The replication study generates the hypothesis that mTOR signalling pathway may be involved in NODAT...
Source: BBA Clinical - February 9, 2016 Category: Biochemistry Source Type: research
Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD)
Conclusions These represent the first serum biochemical data to stratify MCI and LOAD patients, advancing efforts to biochemically define patient heterogeneity in cognitive disorders. General Significance Lipidomics offers a new approach for identifying biomarkers and biological targets in cognitive disorders. (Source: BBA Clinical)
Source: BBA Clinical - November 17, 2015 Category: Biochemistry Source Type: research
The mTOR pathway in obesity driven gastrointestinal cancers: Potential targets and clinical trials
Publication date: Available online 12 November 2015 Source:BBA Clinical Author(s): Cian O. Malley, Graham P. Pidgeon The mechanistic target of rapamycin (mTOR) is a crucial point of convergence between growth factor signalling, metabolism, nutrient status and cellular proliferation. The mTOR pathway is heavily implicated in the progression of many cancers and is emerging as an important driver of gastrointestinal (GI) malignancies. Due to its central role in adapting metabolism to environmental conditions, mTOR signalling is also believed to be critical in the development of obesity. Recent research has delineated ...
Source: BBA Clinical - November 13, 2015 Category: Biochemistry Source Type: research
Glioblastomas with copy number gains in EGFR and RNF139 show increased expressions of carbonic anhydrase genes transformed by ENO1
Conclusions Glioblastomas with CN increases in EGFR had elevated CA3 expression. Similarly, tumors with RNF149 CN gains had elevated CA12 expression. General Significance In larger studies, subgroups of glioblastomas may emerge according to oncogene-related effects on glycolysis, such as control of pH via effects on carbonic anhydrases, with prognostic and treatment implications. Graphical abstract (Source: BBA Clinical)
Source: BBA Clinical - November 11, 2015 Category: Biochemistry Source Type: research
Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links
In conclusion, IBD, CRC and T2DM are commonly occurring interrelated clinical problems. They share a common basis influenced by an inflammatory process, an imbalance in intestinal microbiota, and a crosstalk between various signaling pathways. Would probiotics interrupt the crosstalk or orient it in the physiological direction? (Source: BBA Clinical)
Source: BBA Clinical - November 6, 2015 Category: Biochemistry Source Type: research
Baseline white matter microstructural integrity is not related to cognitive decline after 5years: The RUN DMC study
Publication date: December 2015 Source:BBA Clinical, Volume 4 Author(s): I.W.M. van Uden, H.M. van der Holst, P. Schaapsmeerders, A.M. Tuladhar, A.G.W. van Norden, K.F. de Laat, D.G. Norris, J.A.H.R. Claassen, E.J. van Dijk, E. Richard, R.P.C. Kessels, F.-E. de Leeuw (Source: BBA Clinical)
Source: BBA Clinical - November 4, 2015 Category: Biochemistry Source Type: research
Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study
Publication date: Available online 28 October 2015 Source:BBA Clinical Author(s): Dunja Westhoff, Joost Witlox, Corneli van Aalst, Rikie M. Scholtens, Sophia E. de Rooij, Barbara C. van Munster, Jos F.M. de Jonghe, Alexander P.J. Houdijk, Piet Eikelenboom, David J. van Westerloo, Diederik van de Beek, Willem A. van Gool, Leo Koenderman (Source: BBA Clinical)
Source: BBA Clinical - October 28, 2015 Category: Biochemistry Source Type: research
Baseline white matter microstructural integrity is not related to cognitive decline after 5years; The RUN DMC study
Publication date: Available online 26 October 2015 Source:BBA Clinical Author(s): I.W.M. van Uden, H.M. van der Holst, P. Schaapsmeerders, A.M. Tuladhar, A.G.W. van Norden, K.F. de Laat, D.G. Norris, J.A.H.R. Claassen, E.J. van Dijk, E. Richard, R.P.C. Kessels, F.-E. de Leeuw (Source: BBA Clinical)
Source: BBA Clinical - October 26, 2015 Category: Biochemistry Source Type: research
Knowledge of carbohydrate counting and insulin dose calculations in paediatric patients with type 1 diabetes mellitus
Conclusions This study demonstrates that in a representative Irish regional paediatric T1DM clinic, knowledge of carbohydrates and insulin is better among patients treated with CSII compared with MDI. However, knowledge in both groups is poorer than in the original US sample. General Significance. This study demonstrates that in a representative Irish regional paediatric T1DM clinic, knowledge of carbohydrates and insulin is poorer than in a US based sample, although this knowledge is better among patients treated with CSII compared with MDI. this highlights the need for improved resources for diabetes and carbohydrate ...
Source: BBA Clinical - September 17, 2015 Category: Biochemistry Source Type: research
