Launch of BBA Clinical: Translating molecular insights to clinical research
Publication date: June 2014 Source:BBA Clinical, Volume 1 Author(s): Jeffrey N. Keller (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Clinical spectrum of non-alcoholic fatty liver disease in diabetic and non-diabetic patients
Conclusion Patients with DM have more severe NAFLD based on histology. However, NASH and advanced fibrosis also occur in a considerable proportion of NAFLD patients without DM. The lower utility of the NFS in NAFLD patients without DM emphasises the heterogeneous nature of the NAFLD phenotype. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Positivity of both plasma Epstein-Barr virus DNA and serum Epstein-Barr virus capsid specific immunoglobulin A is a better prognostic biomarker for nasopharyngeal carcinoma
Conclusion These data indicated that positivity for both EBV-DNA and VCA-IgA was a better biomarker for the prognosis of patients with NPC. Our findings may provide new references for clinical practice. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo
Conclusions: Taken together, these data suggest that serum fortilin levels reflect the degree and extent of apoptosis occurring in vivo. General significance: Fortilin is a viable serum biomarker of in vivo apoptosis and can be utilized to noninvasively assess the status of in vivo apoptosis in humans. Graphical abstract (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension
Publication date: December 2014 Source:BBA Clinical, Volume 2 Author(s): Vittoria Matafora , Laura Zagato , Mara Ferrandi , Isabella Molinari , Gianpaolo Zerbini , Nunzia Casamassima , Chiara Lanzani , Simona Delli Carpini , Francesco Trepiccione , Paolo Manunta , Angela Bachi , Giovambattista Capasso Hypertension is a prevalent disorder in the world representing one of the major risk factors for heart attack and stroke. These risks are increased in salt sensitive individuals. Hypertension and salt sensitivity are complex phenotypes whose pathophysiology remains poorly understood and, remarkably, salt sensi...
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Viral load is associated with abnormal serum levels of micronutrients and glutathione and glutathione-dependent enzymes in genotype 3 HCV patients
Conclusion As a significant correlation was detected between the study parameters in genotype 3 HCV patients, it is concluded that the studied micronutrients and glutathione and glutathione-dependent enzymes are the biomolecular targets of HCV to induce oxidative stress. General significance Constant monitoring and regulation of the recommended biomolecular targets of HCV can improve the plight of more than 170 million patients suffering from hepatitis C virus around the globe. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry
Conclusion Based on our results, we propose the best biochemical parameters predictive for defects of respiratory complexes I, IV and V manifesting in peripheral blood lymphocytes. General significance The noninvasiveness, reliability and speed of an approach utilizing novel biochemical criteria demonstrate the high potential of isolated lymphocytes for diagnostics of oxidative phosphorylation disorders in pediatric patients. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
An altered GABA-A receptor function in spinocerebellar ataxia type 6 and familial hemiplegic migraine type 1 associated with the CACNA1A gene mutation
Conclusions Cerebellar glucose hypometabolism and an altered GABA-A receptor function are characteristic of FHM1 and SCA6. General significance An altered GABA-A receptor function has previously been reported in models of inherited murine cerebellar ataxia caused by a mutation in the CACNA1A gene. This study showed novel clinical characteristics of alteration in the GABA-A receptor in vivo, which may provide clinical evidence indicating a pathological mechanism common to neurological disorders associated with CACNA1A gene mutation. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Age-specific non-invasive transcutaneous Doppler ultrasound derived haemodynamic reference ranges in elderly Chinese adults
Conclusions Ageing does not have any significant effect on resting haemodynamics in the elderly population studied. Mild chronic disease does not adversely affect resting haemodynamics in this population. General Significance Reference ranges were established for 21 haemodynamic parameters, as measured by USCOM, for an elderly Chinese population but not for non-Chinese populations. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Left atrial strain as evaluated by two-dimensional speckle tracking predicts left atrial appendage dysfunction in patients with acute ischemic stroke
Conclusion Decreased LA peak systolic strain was independently associated with LAA dysfunction in patients with acute ischemic stroke. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide
Conclusions Buccal cells can predict exposure to ROS through increased levels of S-glutathionylation of proteins. These post-translationally modified proteins serve as biomarkers for the effects of H2O2 in the oral cavity and in the future, may be adaptable as extrapolated pharmacodynamic biomarkers for assessing the impact of other systemic drugs that cause ROS and/or impact redox homeostasis. General significance S-glutathionylation of buccal cell proteins can be used as a quantitative measure of exposure to ROS. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients
Conclusions The area under the curve value for Fibrinogen compared favourably with cancer antigen 15-3, an established breast cancer tumour marker. A combination of all three biomarkers improved accuracy when comparing control/benign to stage IV breast cancer patient groups. General significance Mass spectrometry profiling of Transferrin-bound proteins has revealed serum proteins that can distinguish between serum from advanced breast cancer patients and healthy control subjects with high confidence. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood
Conclusion We present absolute quantitative data on the TIF-to-plasma gradient of selected proteins in the tumor microenvironment, and demonstrate a substantial and stage dependent gradient for CA-125 between TIF and plasma, suggesting a relation between total tumor burden and tissue-to-plasma gradient. General significance We present novel quantitative data on biomarker concentration in the tumor microenvironment, and a new strategy for biomarker selection, applicable in future biomarker studies. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers
Conclusions ATM, ATR and DNA-PKcs expressions may have prognostic and predictive significances in epithelial ovarian cancer. General significance The data presented here provides evidence that ATM, ATR and DNA-PKcs involved in DDR are not only promising biomarkers but are also rational targets for personalized therapy in ovarian cancer. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly
Conclusion Although plasma zinc level is inversely related to systemic inflammatory activity, its plasma levels of daily intake are not associated to alterations in structure or function of the arterial wall. General significance In the very elderly plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis or atherosclerotic burden at coronary or carotid arteries. (Source: BBA Clinical)
Source: BBA Clinical - November 1, 2014 Category: Biochemistry Source Type: research
