Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry

Conclusion Based on our results, we propose the best biochemical parameters predictive for defects of respiratory complexes I, IV and V manifesting in peripheral blood lymphocytes. General significance The noninvasiveness, reliability and speed of an approach utilizing novel biochemical criteria demonstrate the high potential of isolated lymphocytes for diagnostics of oxidative phosphorylation disorders in pediatric patients.
Source: BBA Clinical - Category: Biochemistry Source Type: research