Heart-type Fatty Acid Binding Protein and High-Sensitivity Troponin T are Myocardial Damage Markers that Could Predict Adverse Clinical Outcomes in Patients with Peripheral Artery Disease
Conclusion The myocardial damage markers H-FABP and hsTnT were increased in PAD patients with CLI and could predict MACCEs in PAD patients. (Source: BBA Clinical)
Source: BBA Clinical - June 19, 2015 Category: Biochemistry Source Type: research
Treatment of non-muscle invasive bladder cancer with Bacillus Calmette–Guerin (BCG): Biological markers and simulation studies
Publication date: Available online 10 June 2015 Source:BBA Clinical Author(s): Alex Kiselyov , Svetlana Bunimovich-Mendrazhitsky , Vladimir Startsev Intravesical Bacillus Calmette–Guerin (BCG) vaccine is the preferred first line treatment for non-muscle invasive bladder carcinoma (NMIBC) in order to prevent recurrence and progression of cancer. There is ongoing need for the rational selection of i) BCG dose, ii) frequency of BCG administration along with iii) synergistic adjuvant therapy and iv) a reliable set of biochemical markers relevant to tumor response. In this review we evaluate cellular and molecular mark...
Source: BBA Clinical - June 13, 2015 Category: Biochemistry Source Type: research
Treatment of Non-muscle invasive bladder cancer with Bacillus calmette-guerin (BCG): Biological markers and simulation studies
Publication date: Available online 10 June 2015 Source:BBA Clinical Author(s): Alex Kiselyov , Svetlana Bunimovich-Mendrazhitsky , Vladimir Startsev Intravesical Bacillus Calmette-Guerin (BCG) vaccine is the preferred first line treatment for non-muscle invasive bladder carcinoma (NMIBC) in order to prevent recurrence and progression of cancer. There is ongoing need for the rational selection ofi) BCG dose, ii) frequency of BCG administration along with iii) synergistic adjuvant therapy and iv) a reliable set of biochemical markers relevant to tumor response. In this review we evaluate cellular and molecular markers...
Source: BBA Clinical - June 12, 2015 Category: Biochemistry Source Type: research
Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients
Publication date: Available online 10 June 2015 Source:BBA Clinical Author(s): Sergio J. Montano , Jacob Grünler , Deepika Nair , Michael Tekle , Aristi P. Fernandes , Xiang Hua , Arne Holmgren , Kerstin Brismar , Johanna S. Ungerstedt (Source: BBA Clinical)
Source: BBA Clinical - June 12, 2015 Category: Biochemistry Source Type: research
A multifunctional ELISA to measure oxidised proteins: oxPin1 in Alzheimer's brain as an example
Publication date: December 2015 Source:BBA Clinical, Volume 4 Author(s): Megan K. Herbert , Marcel M. Verbeek , Benno Küsters , H. Bea Kuiperij (Source: BBA Clinical)
Source: BBA Clinical - June 5, 2015 Category: Biochemistry Source Type: research
Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: a randomized placebo controlled trial
Conclusions Three months of caloric restriction with DHA+EPA supplementation exerts beneficial effects on insulin resistance, GIP and triglycerides. General Significance Combining caloric restriction and n-3 PUFA improves insulin sensitivity, which may be related to a decrease of GIP levels. This trial was registered at isrctn.com as ISRCTN11445521. (Source: BBA Clinical)
Source: BBA Clinical - May 23, 2015 Category: Biochemistry Source Type: research
A multifunctional ELISA to measure oxidised proteins: oxPin1 in Alzheimer brain as an example
Publication date: Available online 30 April 2015 Source:BBA Clinical Author(s): Megan K. Herbert , Marcel M. Verbeek , Benno Küsters , H. Bea Kuiperij (Source: BBA Clinical)
Source: BBA Clinical - May 5, 2015 Category: Biochemistry Source Type: research
Cardiometabolic and vascular risks in young and adolescent girls with Turner syndrome
Publication date: Available online 30 April 2015 Source:BBA Clinical Author(s): Meenal Mavinkurve , Clodagh S. O'Gorman Background Turner syndrome (TS) is the most common chromosomal abnormality in females and is associated with several co-morbidities. It commonly results from X monosomy which is diagnosed on a 30 cell karyotype. Congenital heart disease is a clinical feature in 30% of cases. It is becoming evident that TS patients have an increased risk of cardiovascular and cerebrovascular diseases. Scope of review This review provides a detailed overview of the literature surrounding cardiometabolic health in ch...
Source: BBA Clinical - May 3, 2015 Category: Biochemistry Source Type: research
Cardiometabolic and vascular risk in young and adolescent girls with Turner Syndrome
Conclusions Current epidemiological evidence suggests that young women and girls with TS have unfavourable cardiometabolic risk factors which predispose them to adverse cardiac and cerebrovascular outcomes in young adulthood. It remains unclear whether this risk is the result of unidentified factors which are intrinsic to TS, or whether modifiable risk factors (obesity, hypertension, hyperglycaemia) are contributing to this risk. General Significance From a clinical perspective, this review highlights the importance of regular screening and pro-active management of cardiometabolic risk from childhood in TS cohorts and th...
Source: BBA Clinical - April 30, 2015 Category: Biochemistry Source Type: research
A multifunctional ELISA to measure oxidized proteins: oxPin1 in Alzheimer brain as an example
Publication date: Available online 30 April 2015 Source:BBA Clinical Author(s): Megan K. Herbert , Marcel M. Verbeek , Benno Küsters , H. Bea Kuiperij (Source: BBA Clinical)
Source: BBA Clinical - April 30, 2015 Category: Biochemistry Source Type: research
Multifactorial determinants of cognition — Thyroid function is not the only one
Publication date: Available online 22 April 2015 Source:BBA Clinical Author(s): Roy Moncayo , Karina Ortner Background Since the 1960s hypothyroidism together with iodine deficiency have been considered to be a principal determinant of cognition development. Following iodine supplementation programs and improved treatment options for hypothyroidism this relation might not be valid in 2015. On the other hand neurosciences have added different inputs also related to cognition. Scope of review We will examine the characteristics of the original and current publications on thyroid function and cognition and also add so...
Source: BBA Clinical - April 27, 2015 Category: Biochemistry Source Type: research
Multifactorial determinants of cognition – Thyroid function is not the only one
Conclusions Recent studies have failed to show an influence of thyroid medication during pregnancy on intellectual development. Neuroscience offers a better explanation of cognition than hypothyroidism and iodine deficiency. Additional factors relevant to cognition are nutrition, infection, prenatal stress, and early life stress. In turn stress is related to low magnesium levels. Magnesium supplementation can correct both latent hypothyroidism and acquired mild cognitive deficits. General significance Cognition is a complex process that depends on many determinants and not only on thyroid function. Magnesium deficiency app...
Source: BBA Clinical - April 24, 2015 Category: Biochemistry Source Type: research
Cognitive impairment as a central cholinergic deficit in patients with Myasthenia Gravis
Conclusions VCmax and ACmax are governed mainly by the action of the Parasympathetic Nervous System, through acetylcholine. The results of this study demonstrate that the CNS may be affected in MG and support the hypothesis that MG has central cholinergic effects manifested by cognitive dysfunction. (Source: BBA Clinical)
Source: BBA Clinical - April 24, 2015 Category: Biochemistry Source Type: research
Recent advances in the field of anti-cancer immunotherapy
Publication date: Available online 18 April 2015 Source:BBA Clinical Author(s): Henrique Neves , Hang Fai Kwok Background : The main goal of anti-cancer therapy is to specifically inhibit the malignant activity of cancer cells, whilst leaving healthy cells unaffected. As such, for every proposed therapy, it is important to keep in mind the therapeutic index – the ratio of the toxic dose over the therapeutic dose. The use of immunotherapy has allowed a means to both specifically block protein-protein interaction and deliver cytotoxic events to a tumor-specific antigen. Review scope: It is the objective of this r...
Source: BBA Clinical - April 19, 2015 Category: Biochemistry Source Type: research
Effect of nadroparin on Anti-Xa activity during nocturnal hemodialysis
Conclusion Dosing of nadroparin according to Dutch guidelines in patients on nocturnal hemodialysis does not lead to accumulation of nadroparin. We therefore consider the Dutch dosage guidelines for nadroparin an effective and safe strategy. General Significance this article is the first to present data on anti-Xa activity during nocturnal hemodialysis which is a widely used and potentially dangerous therapie. (Source: BBA Clinical)
Source: BBA Clinical - March 31, 2015 Category: Biochemistry Source Type: research
