Lipoprotein particles and size, total and high molecular weight adiponectin, and leptin in relation to incident coronary heart disease among severely obese postmenopausal women: The Women’s Health Initiative Observational Study
Conclusions : Higher CHD risk among severely obese postmenopausal women is strongly associated with modifiable concentrations of LDL-P and HDL-P, independent of diabetes, smoking, hypertension, physical activity, BMI and waist circumference. General Significance : Severely obese postmenopausal women should be considered high risk candidates for lipid lowering therapy. (Source: BBA Clinical)
Source: BBA Clinical - March 17, 2015 Category: Biochemistry Source Type: research
Calcitriol/Calcifediol ratio: an indicator of vitamin D hydroxylation efficiency?
In conclusion 1,25D/25D can reflect the efficiency of vitaminD hydroxylases more than separate evaluation of 25D and 1,25D and could facilitate the therapeutic choices in different patient populations. (Source: BBA Clinical)
Source: BBA Clinical - March 16, 2015 Category: Biochemistry Source Type: research
The Fate of Chemoresistance in Triple Negative Breast Cancer (TNBC)
Publication date: Available online 12 March 2015 Source:BBA Clinical Author(s): Elma A. O’Reilly , Luke Gubbins , Shiva Sharma , Riona Tully , Matthew Ho Zhing Guang , Karolina Weiner-Gorzel , John McCaffrey , Michele Harrison , Fiona Furlong , Malcolm Kell , Amanda McCann Background Treatment options for women presenting with triple negative breast cancer (TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with standard chemotherapy such as paclitaxel (Taxol®). Following chemotherapy, the ideal tumour response is apoptotic cell death. Post-chemotherapy, cells can maint...
Source: BBA Clinical - March 13, 2015 Category: Biochemistry Source Type: research
Truncated HSPB1 causes axonal neuropathy and impairs tolerance to unfolded protein stress
Conclusion Our results suggest that truncation of the non-conserved C-terminus impairs the function of HSPB1 in cellular stress response. General significance sHSPs have important roles in prevention of protein aggregates that induce toxicity. We showed that C-terminal part of HSPB1 is critical for tolerance of unfolded protein stress, and when lacking causes axonal neuropathy in patients. Graphical abstract (Source: BBA Clinical)
Source: BBA Clinical - March 12, 2015 Category: Biochemistry Source Type: research
Lowering blood glucose during hip surgery does not influence coagulation activation
Conclusion Although the human GLP-1 analogue liraglutide moderately reduced post-operative blood glucose levels in non-diabetic and prediabetic obese patients undergoing elective hip surgery, no changes were observed with respect to coagulation activation. (Source: BBA Clinical)
Source: BBA Clinical - March 12, 2015 Category: Biochemistry Source Type: research
Variation of fibrinogen oligosaccharide structure in the acute phase response: Possible haemorrhagic implications
Conclusions and implications The failure of incorporation Gal excludes the possibility of the hepatic NAcNeu Gal transferase capping the oligosaccharides with sialic acid. This has two desirable haemostatic outcomes: fibrin monomers will polymerise and form clots more rapidly, and two galactose residues can never be exposed diminishing uptake of the protein by the asialoglycoprotein receptor and ramping up concentration at a time of challenge. (Source: BBA Clinical)
Source: BBA Clinical - March 10, 2015 Category: Biochemistry Source Type: research
Variation of fibrinogen oligosaccharide structure in the acute phase response; possible haemorrhagic implications
Conclusions and implications The failure of incorporation Gal excludes the possibility of the hepatic NAcNeu Gal transferase capping the oligosaccharides with sialic acid. This has two desirable haemostatic outcomes, fibrin monomers will polymerise and form clots more rapidly, and two galactose residues can never be exposed diminishing uptake of the protein by the asisloglycoprotein receptor and ramping up concentration at a time of challenge. (Source: BBA Clinical)
Source: BBA Clinical - March 6, 2015 Category: Biochemistry Source Type: research
The role of magnesium and thyroid function in early pregnancy after in-vitro fertilization (IVF): new aspects in endocrine physiology
Conclusions In connection with the initiation of pregnancy following ovarian stimulation dynamic changes of magnesium and TSH levels can be observed. A positive correlation was found between fT4 and TSH in IVF pregnancies. In spontaneous pregnancies smaller increases of TSH levels are related to higher magnesium levels. General significance We propose that magnesium plays a role in early pregnancy as well as in pregnancy success independently from anti-Müllerian hormone. Neither thyroid hormones nor thyroid antibodies were related to outcome. (Source: BBA Clinical)
Source: BBA Clinical - March 6, 2015 Category: Biochemistry Source Type: research
Onco-proteogenomics identifies urinary S100A9 and GRN as potential combinatorial biomarkers for early diagnosis of hepatocellular carcinoma
Publication date: Available online 3 March 2015 Source:BBA Clinical Author(s): Chun-Hao Huang , Chao-Jen Kuo , Shih-Shin Liang , Shu-Wen Chi , Edward Hsi , Chi-Chao Chen , King-Teh Lee , Shyh-Horng Chiou Hepatocellular carcinoma (HCC), the major type of liver cancer, is among the most lethal cancers owing to its aggressive nature and frequently late detection. Therefore, the possibility to identify early diagnostic markers could be of significant benefit. Urine has especially become one of the most attractive body fluids in biomarker discovery as it can be obtained non-invasively in large quantities and is stab...
Source: BBA Clinical - March 3, 2015 Category: Biochemistry Source Type: research
Polymorphisms in IL-10 and INF-γ genes are associated with early atherosclerosis in coronary but not in carotid arteries: A study of 122 autopsy cases of young adults
In conclusion, we observed that the high prevalence of early atherosclerosis in young adults is associated with IFN-γ (p < 0.001) and IL-10 (p = 0.013) genotypes. This association is blood vessel dependent. Our findings suggest that the vascular system presents site specialization, and specific genetic variations may provide future biomarkers for early disease identification. (Source: BBA Clinical)
Source: BBA Clinical - March 3, 2015 Category: Biochemistry Source Type: research
First Pregnancy Characteristics, Postmenopausal Breast Density, and Salivary Sex Hormone Levels in a Population at High Risk for Breast Cancer
Conclusions and General Significance While reproductive characteristics, in particular parity, generally demonstrated independent associations with postmenopausal breast density and E, P and DHEA levels, T levels showed concordant inverse associations with age-at-first birth and breast density. These findings suggest that reproductive effects and later life salivary sex steroid hormone levels may have independent effects on later life breast density and cancer risk. (Source: BBA Clinical)
Source: BBA Clinical - February 20, 2015 Category: Biochemistry Source Type: research
Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy
Conclusions Enhanced FA uptake into hepatocytes and lipogenesis, up-regulation of PPARγ, and disruption of VLDL excretion into the circulation are possible mechanisms of steatogenesis after PD. General Significance These results provide a basis for understanding the pathogenesis of NAFLD/NASH following PD. (Source: BBA Clinical)
Source: BBA Clinical - February 19, 2015 Category: Biochemistry Source Type: research
Multiple Sclerosis retrovirus-like envelope gene: role of the chromosome 20 insertion
Conclusions The lack of association with MS risk of the identified polymorphisms together with the transcription results discard chromosome 20 as genomic origin of MSRV-like env. (Source: BBA Clinical)
Source: BBA Clinical - February 19, 2015 Category: Biochemistry Source Type: research
Cancer Metabolism and Oxidative Stress: Insights into Carcinogenesis and Chemotherapy via the Non-Dihydrofolate Reductase Effects of Methotrexate
Publication date: Available online 7 February 2015 Source:BBA Clinical Author(s): Joshua A. Hess , Mohamed Khasawneh Methotrexate has been in use as an anti-cancer agent for over 60 years. Though inhibition of dihydrofolate reductase is its best known mechanisms of action, it’s non-dihydrofolate reductase dependent mechanisms disrupt metabolic pathways resulting in a depletion of NAD(P)H and increasing oxidative stress. These mechanisms highlight a novel dependence of cancer cells on their metabolic abnormalities to buffer oxidative stress and chemotherapeutic agents interfere with these cellular abilities. Mitocho...
Source: BBA Clinical - February 7, 2015 Category: Biochemistry Source Type: research
High Density Lipoproteins: Measurement Techniques and Potential Biomarkers of Cardiovascular Risk
Publication date: Available online 31 January 2015 Source:BBA Clinical Author(s): Anouar Hafiane , Jacques Genest Plasma high density lipoproteins cholesterol (HDL) comprises a heterogeneous family of lipoprotein species, differing in surface charge, size and lipid and protein composition. While HDL cholesterol (C) mass is a strong, graded and coherent biomarker of cardiovascular risk, genetic and clinical trial data suggest that the simple measurement of HDL-C may not be causal in preventing atherosclerosis nor reflect HDL functionality. Indeed, the measurement of HDL-C may be a biomarker of cardiovascular health. T...
Source: BBA Clinical - January 31, 2015 Category: Biochemistry Source Type: research
