Variation of fibrinogen oligosaccharide structure in the acute phase response; possible haemorrhagic implications

Conclusions and implications The failure of incorporation Gal excludes the possibility of the hepatic NAcNeu Gal transferase capping the oligosaccharides with sialic acid. This has two desirable haemostatic outcomes, fibrin monomers will polymerise and form clots more rapidly, and two galactose residues can never be exposed diminishing uptake of the protein by the asisloglycoprotein receptor and ramping up concentration at a time of challenge.

Source: BBA Clinical - March 6, 2015 Category: Biochemistry Source Type: research