Steroid Metabolizing Gene Variant in Polyfactorial Model Improves Risk Prediction in A High Incidence Breast Cancer Population

Conclusions and General Significance Since the optimized PFRM consistently outperformed BCRAT in all Caucasian study populations, it represents an improved personalized risk assessment tool. The finding of higher Marin County risk linked to a CYP11B2 aldosterone synthase SNP associated with essential hypertension offers a new genetic clue to sporadic breast cancer predisposition.
Source: BBA Clinical - Category: Biochemistry Source Type: research