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Novel PCR primers to diagnose visceral leishmaniasis using peripheral blood, spleen or bone marrow aspirates
Conclusions The newly designed primer MK1F/R could be a better alternative for PCR based diagnosis of VL using less invasive sample, peripheral blood instead of bone marrow or spleen aspirates. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 22, 2017 Category: Tropical Medicine Source Type: research

Measurement of total phenolic content and antioxidant activity of aerial parts of medicinal plant Coronopus didymus
Conclusions The total phenolic content of extracts in decreasing order is ethanol extract (CDA Et) > acetone extract (CDA ACE)> phenolic extract (CDA MW)> n-hexane extract (CDA nHX)> chloroform extract (CDA CHL)> dichloromethane extract (CDA DCM). The ordering of extracts in terms of antioxidant activity from highest to lowest is CDA Et> CDA MW> CDA DCM> CDA CHL> CDA ACE> CDA nHX in DPPH, ABTS and FRAP assays. A significant relationship is found between antioxidant potential and total phenolic content, suggesting that phenolic compounds are the major con...
Source: Asian Pacific Journal of Tropical Medicine - August 20, 2017 Category: Tropical Medicine Source Type: research

Prediction of promiscuous T cell epitopes in RNA dependent RNA polymerase of Chikungunya virus
Conclusions Epitopes reported in this study showed promiscuity, antigenicity as well as good binding affinity for the HLA classes. These epitopes will provide the baseline for development of efficacious vaccine for CHIKV. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 20, 2017 Category: Tropical Medicine Source Type: research

Recent research advances on Chromobacterium violaceum
Publication date: Available online 19 August 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Vijay Kothari, Sakshi Sharma, Divya Padia Chromobacterium violaceum is a gram-negative bacterium, which has been used widely in microbiology labs involved in quorum sensing (QS) research. Among the QS-regulated traits of this bacterium, violacein production has received the maximum attention. Violacein production in this organism, however is not under sole control of QS machinery, and other QS-regulated traits of this bacterium also need to be investigated in better detail. Though not often involved in human ...
Source: Asian Pacific Journal of Tropical Medicine - August 20, 2017 Category: Tropical Medicine Source Type: research

Chemical composition, antioxidant, and antibacterial activity of essential oils from Etlingera sayapensis A.D. Poulsen & amp; Ibrahim
Conclusions The most components of the essential oils belong to oxygenated monoterpenes. Linalool formate, carvone, and α-terpineol are found as the most abundant compounds in the oils of the different parts of E. sayapensis. The rhizomes oil can prevent the growth of wide spectrum microorganisms; however, the oils are not highly potent in antioxidant assays. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 20, 2017 Category: Tropical Medicine Source Type: research

Medicinal plant products targeting quorum sensing for combating bacterial infections
Publication date: Available online 19 August 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Abdelhakim Bouyahya, Nadia Dakka, Abdeslam Et-Touys, Jamal Abrini, Youssef Bakri Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and bi...
Source: Asian Pacific Journal of Tropical Medicine - August 20, 2017 Category: Tropical Medicine Source Type: research

Growth inhibitory effect of phenolic extracts of Ziziphus jujuba Mill. in dengue vector Aedes aegypti (L) in parent and F1 generation
Conclusions It is concluded that the phenolic extract of the leaves of Ziziphus jujuba is a potential candidate for control of Aedes mosquitoes. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 20, 2017 Category: Tropical Medicine Source Type: research

Effect of tetramethylpyrazin combined with cisplatin on VEGF, KLF4 and ADAMTS1 in lewis lung cancer mice
Conclusion: KLF4 and ADAMTS1 may be synergically involved in the angiogenesis in mouse Lewis lung cancer through the different signal ways. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 19, 2017 Category: Tropical Medicine Source Type: research

In  vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype
Conclusions siRNAs directed against NS3 gene significantly decreased mRNA and protein expression in stable cell clones. Viral replication was also vividly decreased in serum infected Huh-7 cells. Stable Huh-7 cells expressing NS3 gene is helpful to develop anti-hepatitis C drug screening assays. siRNA therapeutic potential along with other anti-HCV agents can be considered against hepatitis C. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 18, 2017 Category: Tropical Medicine Source Type: research

In vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype
Conclusions siRNAs directed against NS3 gene significantly decreased mRNA and protein expression in stable cell clones. Viral replication was also vividly decreased in serum infected Huh-7 cells. Stable Huh-7 cells expressing NS3 gene is helpful to develop anti-hepatitis C drug screening assays. siRNA therapeutic potential along with other anti-HCV agents can be considered against hepatitis C. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 9, 2017 Category: Tropical Medicine Source Type: research

Solvent –solvent fractionations of Combretum erythrophyllum (Burch.) leave extract: Studies of their antibacterial, antifungal, antioxidant and cytotoxicity potentials
Conclusions It can be concluded that the extracts of C. erythrophyllum are safe for medicinal use in folk medicine for treating infectious and stress related diseases. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 2, 2017 Category: Tropical Medicine Source Type: research

Chemical analysis and in  vitro antimicrobial effects and mechanism of action of Trachyspermum copticum essential oil against Escherichia coli
Conclusions These results indicate that T. copticum EO is a good natural antibacterial agent for food-borne pathogens. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - August 2, 2017 Category: Tropical Medicine Source Type: research

Mechanism of antagonistic effects of Andrographis paniculata methanolic extract against Staphylococcus aureus
Conclusions Taken together these results suggest that the low MIC of A. paniculata methanolic leaves extract (0.06 mg/mL) reduce H2O2 toxicity and more importantly, was in itself effectively inhibitory against S. aureus. Further, our observations suggest that a probable mode of its inhibitory mechanism against S. aureus is by reducing total SOD activity through downregulation of sodA and sodM expressions. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - July 29, 2017 Category: Tropical Medicine Source Type: research

Retraction notice to: Effect of thioredoxin-interacting protein on Wnt/ β-catenin signaling pathway and diabetic myocardial infarction [Asian Pac J Trop Med 8(11) (2015) 976–982]
Publication date: June 2017 Source:Asian Pacific Journal of Tropical Medicine, Volume 10, Issue 6 Author(s): Hui Yu, Xian-Xian Zhao, Xing-Hua Shan, Pan Li, Tao Chen (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - July 28, 2017 Category: Tropical Medicine Source Type: research

Retraction notice to: Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats [Asian Pac J Trop Med 8(12) (2015) 1060 –1063]
Publication date: June 2017 Source:Asian Pacific Journal of Tropical Medicine, Volume 10, Issue 6 Author(s): Zhen-Lv Lin, Guang-Wei Zheng, Lin Zhang, Jian-Tao Zheng, Hui Chen (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - July 28, 2017 Category: Tropical Medicine Source Type: research