Preventive and therapeutic effect of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage
Conclusions Simvastatin can inhibit the expressions of NF-κB, TLR4 and IL-1β proteins in rats with cerebral hemorrhage, and protect neurons and reduce secondary inflammatory damages by down-regulating the above protein-mediated inflammatory responses. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Targeted inhibition of Notch1 gene enhances the killing effects of Paclitaxel on triple-negative breast cancer cells
Conclusions Targeted inhibition of Notch1 gene may enhance the killing effects of paclitaxel on triple-negative breast cancer cells by up-regulating the expression of Caspase-3 and Caspase-9 and inhibiting the expression of Bcl-2. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Immunological reactive rate to Zika virus in canine sera: a report from a tropical area and concern on pet, zoonosis and reservoir host
Publication date: Available online 19 January 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Beuy Joob, Viroj Wiwanitkit This letter to editor discusses and describes Zika virus IgG seropositivity rate in canine sera from endemic area. This is the first world report and it raises an urgent concern on pet, zoonosis and reservoir host regarding Zika virus. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

A cross-sectional study into the correlation of common household risk factors and allergic rhinitis in Taiwan ’s tropical environment
Conclusions Use of bedroom shower is a potential risk factor for allergic rhinitis development. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Expression and clinical significance of high risk human papillomavirus and invasive gene in cervical carcinoma
Conclusions The expression of the detection of cervical cancer in high-risk human papilloma virus HPV-18 E6 and E7 mRNA, and the invasion, migration, proliferation inhibition gene, epithelial mesenchymal transition and proliferation related gene protein content, HPV expression rate of mRNA increased with the development of cervical cancer, the expression is also enhanced. The expression has a certain correlation between the level and development of cervical cancer. Through the above indicators, the development of cervical cancer monitoring and treatment to provide important clinical guidance. (Source: Asian Pacific Journal...
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Phytochemical and ethnopharmacological review of Elephantorrhiza goetzei (Harms) Harms
Publication date: Available online 20 January 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Alfred Maroyi Elephantorrhiza goetzei (E. goetzei) commonly known as Goetze’s elephantorrhiza, is traditionally used as a decoction in the treatment of a variety of conditions such as pain, sores, sexually transmitted infections (STIs), gastro-intestinal disorders, microbial infections and genito-urinary system disorders. On the basis of its wide distribution in south central Africa, E. goetzei has a long history of applications among the different ethnic groups. A total of 23 ethnomedicinal uses of E. goetz...
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Natural variability of essential oil and antioxidants in the medicinal plant Turnera diffusa
Conclusions Results suggest that climatic differences and origin influence the phytochemicals in the medicinal plant T. diffusa, and thus, it is worth to consider such effects for industrial and medicinal purposes. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Effect of curcumin on expressions of NF- κBp65, TNF-α and IL-8 in placental tissue of premature birth of infected mice
Conclusions Curcumin can effectively prevent the active pathway of NF-κB in pregnant tissue of premature birth of infected mice, reduce the expression of TNF-α and IL-8 and relieve the damage of lipid peroxide of oxidative stress of LPS on mother-fetus and further to achieve the objective of preventing and curing premature birth induced with infection. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Sevoflurane pretreatment inhibits the myocardial apoptosis caused by hypoxia reoxygenation through AMPK pathway: An experimental study
Conclusions Sevoflurane pretreatment can activate AMPK signaling pathway to inhibit the myocardial apoptosis caused by hypoxia reoxygenation. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Homozygosity for the CD1E*02 allele is associated with a resistance to Plasmodium falciparum malaria infection in Gabonese school children
Conclusion Our results suggest a possible role of CD1E polymorphisms in malaria protection among school children and that CD1e molecules are involved in anti-malarial immunity. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Prostatic abscess of Klebsiella  pneumonia complicating septic pulmonary emboli and meningitis: A case report and brief review
Publication date: Available online 28 December 2016 Source:Asian Pacific Journal of Tropical Medicine Author(s): Jai-Wen Liu, Tzu-Chieh Lin, Yao-Tien Chang, Che-An Tsai, Sung-Yuan Hu Prostatic abscess is a rare entity with an incidence of 0.5%–2.5% in all prostate diseases and usually occurs in the 5th and 6th decades of life with immunocompromised status. Prostatic abscess might be a process of evolution from acute prostatitis. Klebsiella pneumoniae is the leading microorganism in the diabetic patients of prostatic abscess in Taiwan. A 60-year-old diabetic man, with a one-week history of acute bacterial prostatit...
Source: Asian Pacific Journal of Tropical Medicine - January 3, 2017 Category: Tropical Medicine Source Type: research

Situation analysis of cutaneous leishmaniasis in an endemic area, south of Iran
Conclusions This study revealed that CL is present in Kazerun country. Thus, effective monitoring and sustained surveillance system is crucial in counteracting the disease, and if possible, to eliminate it. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - January 1, 2017 Category: Tropical Medicine Source Type: research

Zika virus from a Southeast Asian perspective
Publication date: Available online 27 December 2016 Source:Asian Pacific Journal of Tropical Medicine Author(s): Nitwara Wikan, Duncan R. Smith Phylogenic evidence suggests that the strain of Zika virus causing an unprecedented outbreak of disease in the Americas had its origin in Southeast Asia, where reports of isolated cases of Zika virus infection have occurred since 2010. Why there has been no large outbreak of Zika infection in Southeast Asia remains unclear and whether such an outbreak will occur in the future is a question of significant concern. This review looks at Zika virus from a Southeast Asian perspectiv...
Source: Asian Pacific Journal of Tropical Medicine - December 27, 2016 Category: Tropical Medicine Source Type: research

Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance
Conclusions The high expression of RUNX3 could inhibit tumor microvascular generation in order to have negative control response on invasion and distant metastasis. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 27, 2016 Category: Tropical Medicine Source Type: research

First isolation of glutinol and a bioactive fraction with good anti-inflammatory activity from n-hexane fraction of Peltophorum africanum leaf
Conclusions Bioactive sub-fractions (F3.3 and F3.3.0) derived from the n-hexane fraction of PA had good anti-inflammatory activity, and the isolated compound, and glutinol may be useful as a template for the development of new anti-inflammatory drugs. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - December 27, 2016 Category: Tropical Medicine Source Type: research