Mechanism of antagonistic effects of Andrographis paniculata methanolic extract against Staphylococcus aureus

Conclusions Taken together these results suggest that the low MIC of A. paniculata methanolic leaves extract (0.06 mg/mL) reduce H2O2 toxicity and more importantly, was in itself effectively inhibitory against S. aureus. Further, our observations suggest that a probable mode of its inhibitory mechanism against S. aureus is by reducing total SOD activity through downregulation of sodA and sodM expressions.
Source: Asian Pacific Journal of Tropical Medicine - Category: Tropical Medicine Source Type: research