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Development of lamellar gel phase emulsion containing baru oil (Dipteryx alata Vog.) as a prospective delivery system for cutaneous application
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Cristhianne Moraes, Jorge L.V. Anjos, Monica Maruno, Antonio Alonso, Pedro Rocha-FilhoAbstractThe rational design of emulsions requires study of the main factors that influence their formation, physicochemical properties and, consequently, stability and performance. The use of vegetable oils in the pharmaceutical and cosmetic industries has recently become attractive. Dipteryx alata Vogel (D. alata) is an oleaginous species native to Brazil. The seeds of this species contain highly unsaturated oil with significant amo...
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex
This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.Graphical AbstractFor improving the utilization of NK, a complex of NK-TUDCA to reduce the toxicity of intravenous NK injection, was designed by using NK as the cationic moiety and TUDCA as the anionic moiety. The NK-TUDCA reduced toxicity by the delayed release of NK from the complex and still possessed the inherent powerful efficiency of NK. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery
In this study, spray freeze drying was employed to prepare dry powder of small nucleic acids. Mannitol and herring sperm DNA were used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration were produced. The scanning electron microscope (SEM) images showed that the porosity of the particles increased as the solute concentration decreased. Powders prepared with solute concentration of 5% w/v were found to maintain a balance between porosity and robustness. Increasing concentration of DNA improved the aerosol performance of th...
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Tunable and sustained-release characteristics of venlafaxine hydrochloride from chitosan–carbomer matrix tablets based on in situ formed polyelectrolyte complex film coating
In conclusion, CS–CBM matrix tablets are promising system to tune and control the release of highly water-soluble drugs with good system robustness.Graphical AbstractChitosan–carbomer matrix system is beneficial to tune and control drug release with good system robustness. The in vitro release method can be used as a tool for in vivo bioavailability predication, with level A in vitro and in vivo correlation (IVIVC) established successfully. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery
In this study, we investigated the nucleolus localization abilities and cellular internalization pathways of these two polymers in gene delivery. Each polymer condensed plasmid DNA (pDNA) and formed nanoparticle complexes, and then their transfection studies were performed in MCF-7 cells. Both complexes were found enriched in nucleolus after cellular transfection, and their transfection efficiencies were significantly improved when transfection was performed on MCF-7 cells arrested at M phase. The transfection efficiency of CAR-CBA-pDNA was inhibited by chlorpromazine, and cell endosomes were disrupted after being exposed ...
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research