Asian Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tablets of paliperidone using compression-coated technology for controlled ascending release
This study describes a method of preparation of paliperidone tablets using compression-coated technology for controlled ascending release. The core layer is made up of high viscosity HPC-H and coating layer of HPMC-K100M. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi TakeuchiAbstractWe previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Here, we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation. W...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Role of clove oil in solvent exchange-induced doxycycline hyclate-loaded Eudragit RS in situ forming gel
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Thawatchai Phaechamud, Sai Myo Thurein, Takron ChantadeeAbstractSolvent exchange induced in situ forming gel (ISG) is the promising drug delivery system for periodontitis treatment owing to the prospect of maintaining an effective high drug level in the gingival crevicular fluid. In the present study, the influence of clove oil (CO) on the characteristics of doxycycline hyclate (DH)-loaded ISG comprising Eudragit RS (ERS) was investigated including viscosity/rheology, syringeability, in vitro gel formation/drug releas...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Two kinds of ketoprofen enteric gel beads (CA and CS-SA) using biopolymer alginate
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Bingchao Cheng, Dongyang Li, Qiye Huo, Qianqian Zhao, Qi Lan, Mengsuo Cui, Weisan Pan, Xinggang YangAbstractTo obtain expected rapid-release and sustained-release of ketoprofen gel beads, this paper adopted biopolymer alginate to prepare alginate beads and chitosan-alginate gel beads. Formulation factors were investigated and optimized by the single factor test. The release of ketoprofen from calcium alginate gel beads in pH 1.0 hydrochloric acid solution was less than 10% during 2 h, then in pH6.8 was about 95% dur...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

ROS-responsive drug delivery systems for biomedical applications
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Wenhui Tao, Zhonggui HeAbstractIn the field of biomedicine, stimuli-responsive drug delivery systems (DDSs) have become increasingly popular due to their site-specific release ability in response to a certain physiological stimulus, which may result in both enhanced treatment outcome and reduced side effects. Reactive oxygen species (ROS) are the unavoidable consequence of cell oxidative metabolism. ROS play a crucial part in regulating biological and physiological processes, whereas excessive intracellular ROS usuall...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Combretastatin A4/poly(L-glutamic acid)-graft-PEG conjugates self-assembled to nanoparticles
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Yang Ou, Zhao-hui Tang, Lu Sun, Hai-yang Yu, Jia Li, Mei-hui Zhao, Hui XuAbstractCombretastatin A4 (CA4) possesses varying ability to cause vascular disruption in tumors, while the short half-life, low water solubility and deactivation of many CA4 analogs during storage limited its antitumor efficacy and drug stability. A novel macromolecular conjugate of CA4 (CA4-PL) was synthesized by covalent bonding of CA4 onto poly(L-glutamic acid)-graft-polyethylene glycol (PLG-g-PEG) via Yamaguchi reaction. The obtained CA4-PL ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Development of lamellar gel phase emulsion containing baru oil (Dipteryx alata Vog.) as a prospective delivery system for cutaneous application
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Cristhianne Moraes, Jorge L.V. Anjos, Monica Maruno, Antonio Alonso, Pedro Rocha-FilhoAbstractThe rational design of emulsions requires study of the main factors that influence their formation, physicochemical properties and, consequently, stability and performance. The use of vegetable oils in the pharmaceutical and cosmetic industries has recently become attractive. Dipteryx alata Vogel (D. alata) is an oleaginous species native to Brazil. The seeds of this species contain highly unsaturated oil with significant amo...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex
This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.Graphical AbstractFor improving the utilization of NK, a complex of NK-TUDCA to reduce the toxicity of intravenous NK injection, was designed by using NK as the cationic moiety and TUDCA as the anionic moiety. The NK-TUDCA reduced toxicity by the delayed release of NK from the complex and still possessed the inherent powerful efficiency of NK. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery
In this study, spray freeze drying was employed to prepare dry powder of small nucleic acids. Mannitol and herring sperm DNA were used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration were produced. The scanning electron microscope (SEM) images showed that the porosity of the particles increased as the solute concentration decreased. Powders prepared with solute concentration of 5% w/v were found to maintain a balance between porosity and robustness. Increasing concentration of DNA improved the aerosol performance of th...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Tunable and sustained-release characteristics of venlafaxine hydrochloride from chitosan–carbomer matrix tablets based on in situ formed polyelectrolyte complex film coating
In conclusion, CS–CBM matrix tablets are promising system to tune and control the release of highly water-soluble drugs with good system robustness.Graphical AbstractChitosan–carbomer matrix system is beneficial to tune and control drug release with good system robustness. The in vitro release method can be used as a tool for in vivo bioavailability predication, with level A in vitro and in vivo correlation (IVIVC) established successfully. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery
In this study, we investigated the nucleolus localization abilities and cellular internalization pathways of these two polymers in gene delivery. Each polymer condensed plasmid DNA (pDNA) and formed nanoparticle complexes, and then their transfection studies were performed in MCF-7 cells. Both complexes were found enriched in nucleolus after cellular transfection, and their transfection efficiencies were significantly improved when transfection was performed on MCF-7 cells arrested at M phase. The transfection efficiency of CAR-CBA-pDNA was inhibited by chlorpromazine, and cell endosomes were disrupted after being exposed ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Influence of solvent mixtures on HPMCAS-celecoxib microparticles prepared by electrospraying
This study demonstrated that electrospraying can be used to produce microparticles with tailored properties for pharmaceutical application by adjusting solvent selection.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Development of cryptotanshinone-loaded pellets for angina chronotherapy: In vitro/in vivo prediction and evaluation
In conclusion, this deconvolution-based method could be applied to adjust the in vivo performance of drugs for angina chronotherapy.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug
Publication date: Available online 13 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Patel Mayank, Hirlekar RajashreeAbstractThe purpose of the present study was to investigate the interaction of Cinnarizine (CIN) with Hydroxypropyl-β-Cyclodextrin (HPβCD) in the presence of Hydroxy Acids (HA). Various binary and ternary systems of CIN with HPβCD and HA were prepared by kneading and coevaporation methods. For the ternary systems HA were tried in three different concentrations. The interaction in solution phase was studied in detail by the phase solubility method and the solid phase interactions were...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Creation of an assessment system for measuring the bitterness of azithromycin-containing reverse micelles
In conclusions, a system for assessing bitterness was developed using an in vitro drug release evaluation method and a human taste test panel. We found that the bitterness of azithromycin was successfully masked by reverse micelles, which also improved the oral bioavailability of azithromycin compared to that of Zithromax®.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research