Asian Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy
Publication date: Available online 5 July 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Zhenbao Li, Jiaojiao Zhu, Yongqi Wang, Mei Zhou, Dan Li, Shunzhe Zheng, Cong Luo, Huicong Zhang, Lu Zhong, Wei Li, Jian Wang, Shuangying Gui, Biao Cai, Yongjun Wang, Jin SunAbstractThe therapeutic efficiency of active targeting nanoparticulate drug delivery systems (nano-DDS) is highly compromised by the plasma proteins adsorption on nanoparticles (NPs) surface, which significantly hinders cell membrane receptors to recognize the designed ligands, and provokes the off-target toxicity and rapid clearance of NPs in vivo. ...
Source: Asian Journal of Pharmaceutical Sciences - July 6, 2019 Category: Drugs & Pharmacology Source Type: research

Fluidised bed granulation of two APIs: QbD approach and development of a NIR in-line monitoring method
Publication date: Available online 16 June 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Alexandru Gavan, Sonia Iurian, Tibor Casian, Alina Porfire, Sebastian Porav, Ioana Voina, Alexandru Oprea, Ioan TomutaAbstractThe study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale. The work aimed to prove that an accurate control of the critical granulation parameters can level the input material variability and offer a user-friendly process control strategy. Moreover, an in-line Ne...
Source: Asian Journal of Pharmaceutical Sciences - July 2, 2019 Category: Drugs & Pharmacology Source Type: research

Transdermal Drug Delivery Systems in Diabetes Management: A Review
Publication date: Available online 22 June 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Li Ching Ng, Manish GuptaAbstractDiabetes mellitus is a chronic disease in which there is an insufficient production of insulin by the pancreas, or the insulin produced is unable to be utilized effectively by the body. Diabetes affects more than 415 million people globally and is estimated to strike about 642 million people in 2040. The WHO reported that diabetes will become the seventh biggest cause of mortality in 2030. Insulin injection and oral hypoglycemic agents remain the primary treatments in diabetes managemen...
Source: Asian Journal of Pharmaceutical Sciences - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel
In conclusion, the observed improvement in antinociceptive and anti-inflammatory effects from proniosome carriers signifies its potential to be a suitable alternative to oral therapy of tramadol with greater efficacy.Graphical Abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

Fluidized bed granulation of two APIs: QbD approach and development of a NIR in-line monitoring method
Publication date: Available online 16 June 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Alexandru Gavan, Sonia Iurian, Tibor Casian, Alina Porfire, Sebastian Porav, Ioana Voina, Alexandru Oprea, Ioan TomutaAbstractThe study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale. The work aimed to prove that an accurate control of the critical granulation parameters can level the input material variability and offer a user-friendly process control strategy. Moreover, an in-line Ne...
Source: Asian Journal of Pharmaceutical Sciences - June 16, 2019 Category: Drugs & Pharmacology Source Type: research

A review on anti-bacterials to combat resistance: from ancient era of plants and metals to present and future perspectives of green nano technological combinations
Publication date: Available online 12 June 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Lakshmi Kalyani Ruddaraju, Sri Venkata Narayana Pammi, Guntuku Girija sankar, Veerabhadra Swamy Padavala, Venkata Ramana Murthy KolapalliAbstractIn the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance. Subsequently, nanoparticles (NPs) were proposed to cease the mu...
Source: Asian Journal of Pharmaceutical Sciences - June 12, 2019 Category: Drugs & Pharmacology Source Type: research

Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy
Publication date: Available online 12 June 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yongbing Sun, Wen Ma, Yuanyuan Yang, Mengxue He, Aimin Li, Lei Bai, Bin Yu, Zhiqiang YuAbstractHepatocellular carcinoma (HCC) is one of the deadliest cancers due to its complexities, reoccurrence after surgical resection, metastasis and heterogeneity. In addition to sorafenib and lenvatinib for the treatment of HCC approved by FDA, various strategies including transarterial chemoembolization, radiotherapy, locoregional therapy and chemotherapy have been investigated in clinics. Recently, cancer nanotechnology has got g...
Source: Asian Journal of Pharmaceutical Sciences - June 12, 2019 Category: Drugs & Pharmacology Source Type: research

Simvastatin Nanoliposome Induces Myocardial and Hepatic Toxicities Due to Its Absorption Enhancement in Mice
In this study, organ toxicity of SMV-Lipo was evaluated in mice in the presence and absence of isoproterenol and compared to those of free SMV. Results demonstrated that compared to free SMV, the SMV-Lipo administrated at an equal dose of 25 mg/kg/d led to severe myocardiotoxicity, hepatotoxicity at baseline and more pronounced liver injury with elevation of alanine aminotransferase. In addition, muscular adverse effect was also observed in SMV-Lipo treated group but not in SMV group. Pharmacokinetic studies revealed that compared to free SMV, the SMV-Lipo administration significantly improved the plasma SMV concentration,...
Source: Asian Journal of Pharmaceutical Sciences - May 26, 2019 Category: Drugs & Pharmacology Source Type: research

Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation
Publication date: Available online 24 May 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sha Xiong, Wei Liu, Yile Zhou, Yousheng Mo, Yao Liu, Xiaojia Chen, Huafeng Pan, Dongsheng Yuan, Qi Wang, Tongkai ChenAbstractResveratrol (RES), a non-flavonoid polyphenol extracted from a wide variety of plants, exhibits neuroprotective activities against Parkinson's disease (PD). However, undesirable water solubility of RES reduces its oral bioavailability and demonstrates low efficacy in blood and brain, thus limiting its application. In present study, a nanocrystal formulation of RES (RES-NCs) was developed to enhanc...
Source: Asian Journal of Pharmaceutical Sciences - May 25, 2019 Category: Drugs & Pharmacology Source Type: research

The Functions and Applications of A7R in Anti-angiogenic Therapy, Imaging and Drug Delivery Systems
Publication date: Available online 25 May 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang, Fengshan WangAbstractVascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells. Therefore, targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy. A7R, a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries, can preferentially target VEGFR-2 and NRP-1 and...
Source: Asian Journal of Pharmaceutical Sciences - May 25, 2019 Category: Drugs & Pharmacology Source Type: research

Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells
In conclusion, the targeting tLyp-1 exosomes are successfully engineered, and can be used for gene therapy with a high transfection efficiency. Therefore, the engineered targeting tLyp-1 exosomes offer a promising gene delivery platform for future cancer therapy.Graphical AbstractThe tLyp-1-lamp2b plasmid transfected HEK293T cells can secreted tumor targeting tLyp-1 exosomes. By electroporation technology, targeting tLyp-1 exosomes were loaded with siRNA. When targeting tLyp-1 exosome ruptured in cytoplasm, siRNA was loaded into the RNA-induced silencing complex (RISC). The sense (passenger) strand was degraded while the a...
Source: Asian Journal of Pharmaceutical Sciences - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Let-7 miRNA and CDK4 siRNA co-encapsulated in Herceptin-conjugated liposome for breast cancer stem cells
In conclusion, an efficient liposomal delivery system for the combination of miRNA and siRNA to target the BCSCs was developed and could be used as an efficacious therapeutic modality for breast cancer.Graphical AbstractHerceptin-conjugated cationic liposome can enhance the cellular uptake of let-7 miRNA and CDK4 siRNA toward the HER-2 expressing breast cancer stem cells. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Current multifunctional albumin-based nanoplatforms for cancer multi-mode therapy
Publication date: Available online 1 March 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Chang Li, Xin Wang, Hang Song, Shuai Deng, Wei Li, Jing Li, Sun JinAbstractAlbumin has been widely applied for rational design of drug delivery complexes as natural carriers in cancer therapy due to its distinct advantages of biocompatibility, abundance, low toxicity and versatile property. Hence, various types of multifunctional albumin-based nanoplatforms (MAlb-NPs) that adopt multiple imaging and therapeutic techniques have been developed for cancer diagnosis and treatment. Stimuli-responsive release, including redu...
Source: Asian Journal of Pharmaceutical Sciences - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
Publication date: Available online 25 April 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yixin Sun, Dongyang Zhao, Gang Wang, Qikun Jiang, Mengran Guo, Qiming Kan, Zhonggui He, Jin SunAbstractMonocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs. However, potential application of MCT1 to facilitate the oral delivery is still unclear. Irregular oral absorption, poor permeability and bioavailability greatly limit the oral delivery efficiency o...
Source: Asian Journal of Pharmaceutical Sciences - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Development of composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles for sustained drug release
This study aimed to prepare poly (D, L-lactic-co-glycolic acid) microspheres (PLGA-Ms) by a modified solid-in-oil-in-water (S/O/W) multi-emulsion technique in order to achieve sustained release with reduced initial burst and maintain efficient drug concentration for a prolonged period of time. Composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles (Ex-NPs-PLGA-Ms) were obtained by initial fabrication of exenatide-loaded lecithin nanoparticles (Ex-NPs) via the alcohol injection method, followed by encapsulation of Ex-NPs into PLGA microspheres. Compared to Ms prepared by the conventional water-...
Source: Asian Journal of Pharmaceutical Sciences - April 11, 2019 Category: Drugs & Pharmacology Source Type: research