A review on anti-bacterials to combat resistance: from ancient era of plants and metals to present and future perspectives of green nano technological combinations

Publication date: Available online 12 June 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Lakshmi Kalyani Ruddaraju, Sri Venkata Narayana Pammi, Guntuku Girija sankar, Veerabhadra Swamy Padavala, Venkata Ramana Murthy KolapalliAbstractIn the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance. Subsequently, nanoparticles (NPs) were proposed to cease the multi-drug resistant bacteria but were hindered due to toxicity issues. Recently, a novel adjuvant therapy employed metals and botanicals into innovative nanotechnology as nano-antibiotics. The combination of green synthesized metallic NPs with antibiotics seems to be a viable platform to combat against MDR bacteria by alleviating resistance and toxicity. This review focuses on the primitive to present era dealings with bacterial resistance mechanisms, newer innovations of nanotechnology and their multiple mechanisms to combat resistance. In addition, special focus is paid on greener NPs as antibiotic carriers, and their future prospects of controlled release and toxicity study.Graphical abstractMultidrug-resistant bacteria (MDR) became a global problem as they develop resistance by employing newer mechanisms for every known class of antibiotics. Green synthes...
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research