Asian Journal of Pharmaceutical Sciences 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Non-isothermal dehydration kinetic study of aspartame hemihydrate using DSC, TGA and DSC-FTIR microspectroscopy
Publication date: May 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 3Author(s): Wei-hsien Hsieh, Wen-ting Cheng, Ling-chun Chen, Shan-yang LinAbstractThree thermal analytical techniques such as differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) using five heating rates, and DSC-Fourier Transform Infrared (DSC-FTIR) microspectroscopy using one heating rate, were used to determine the thermal characteristics and the dehydration process of aspartame (APM) hemihydrate in the solid state. The intramolecular cyclization process of APM anhydrate was also examined. One exothermic a...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
DEM modeling of high shear wet granulation of a simple system
Publication date: May 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 3Author(s): Saurabh Sarkar, Bodhisattwa ChaudhuriAbstractHigh shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with high predictive capacity to improve process insight. The DEM model is used to predict agglomeration as a function of impeller speed and liquid addition rate in a high shear wet granulator. The DEM model tracks dynamic formation...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis
In conclusion, intra-articular injection of TMP loaded microspheres was a promising therapeutic method in the treatment of OA.Graphical Abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Preparation of glutinous rice starch/polyvinyl alcohol copolymer electrospun fibers for using as a drug delivery carrier
This study demonstrated a potential application of GRS combining with PVA as an oral drug delivery carrier. Therefore, it can be a promised step that expands the application GRS in pharmaceuticals and related areas.Graphical Abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Succinylated whey protein isolate as a sustained-release excipient of puerarin derivative oral tablets: preparation, optimization and pharmacokinetics
ConclusionThe findings demonstrated that spray-dried S-WPIs has potential as a promising functional excipient for the design of PR-5 oral sustained-release tablets which can fully improve sustained-release effect and oral bioavailability. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization
Publication date: Available online 10 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Jafar Mosafer, Amir-Hossein Sabbaghi, Ali Badiee, Solmaz Dehghan, Mohsen TafaghodiAbstractFor efficient mucosal vaccine delivery, nanoparticulate antigens are better taken by microfold cells in the nasal associated lymphoid tissue and also dendritic cells. Nanoparticles based on polymers such as chitosan (CHT) and its water soluble derivative, trimethylchitosan (TMC), could be successfully used as carrier/adjuvant for this purpose. Sodium alginate, a negatively charged biopolymer, could modify the immunostimulatory p...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis
Publication date: Available online 10 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yang Pan, Xiahui Wang, Zongning YinAbstractTo achieve targeted thrombolysis, a targeted delivery system of lumbrokinase (LK) was constructed using RGDfk-conjugated hybrid micelles. Based on the specific affinity of RGDfk to glycoprotein complex of GPⅡb/Ⅲa expressed on the surface of membrane of activated platelet, LK loaded targeted micelles (LKTM) can be delivered to thrombus. The hybrid micelles were composed of polycaprolactone-block-poly (2-(dimethylamino) ethyl methacrylate) (PCL-PDMAEMA), methoxy polyethyle...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer
Publication date: Available online 10 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yan Liu, Shiya Zhou, Yanlin Gao, Yinglei ZhaiAbstractsDiabetes is one of the most prevalent diseases in the world with high mortality and complex complications including diabetic foot ulcer (DFU). It has been reported that the difficulties in repairing the wound related to DFU has much relationship with the wound infection, change of inflammatory responses, lack of extracellular matrix (ECM), and the failure of angiogenesis. Following the development of medical materials and pharmaceutical technology, nanofibers has bee...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines
This study utilizes, additive manufacturing for rapid prototyping of elements for continuously operating mixing geometries including interfaces with process analytical technology (PAT) tools, to show that 3D printing can be used for prototyping of both parts of production line and PAT interfacing solution. An additional setup was designed for measuring the dynamic calibration samples for a semi-quantitative near infrared (NIR) spectroscopic model. The powder was filled in a small calibration chamber and in-line NIR spectra of calibration samples were collected from moving material while mimicking the powder flow dynamics i...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
A donepezil/cyclodextrin complexation orodispersible film: effect of cyclodextrin on taste-masking based on dynamic process and in vivo drug absorption
Publication date: Available online 24 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Tingting Liu, Xiaocao Wan, Zheng Luo, Chao Liu, Peng Quan, Dongmei Cun, Liang FangAbstractThe aim of this study was to develop a palatable donepezil (DP) orodispersible film (ODF) to facilitate the swallowing process and investigate the effect of cyclodextrin on taste-masking based on dynamic process and in vivo drug absorption. Complexation of DP with hydroxypropyl-β-cyclodextrin (HP-β-CD) was applied to mask the bitter taste then the prepared complexes were incorporated into ODF using solvent casting method. The tas...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Research Progress in In-situ Gelling Ophthalmic Drug Delivery System
Publication date: Available online 24 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe, Bing Zhang, Jing Ren, Jun Lu, Jiawei Li, Shouying Du, Zhidong LiuABSTRACTBlindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein
Publication date: Available online 26 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Jiaxin Pi, Shuya Wang, Wen Li, Dereje Kebebe, Ying Zhang, Bing Zhang, Dongli Qi, Pan Guo, Nan Li, Zhidong LiuAbstractBaicalein (BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but its very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailabilit...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Effect of silicone oil on the microstructure, gelation and rheological properties of sorbitan monostearate-sesame oil oleogels
Publication date: Available online 29 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mya Thet Htar Swe, Panida AsavapichayontAbstractOleogels contain oil or a non-polar liquid which is gelled with an agent called an organogelator. The aim of this study was to evaluate the effects of the addition of silicone oil (cyclopentasiloxane) to the gelation process and to the properties of sorbitan monostearate (SMS)-sesame oil oleogel and compared with that of SMS-sesame oil oleogel and SMS-cyclopentasiloxane oleogel. Three different oil phases; sesame oil phase, cyclopentasiloxane phase and a mixture of cyclope...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Enhanced drug loading efficiency of contact lenses via salt-induced modulation
Publication date: Available online 1 June 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Qiang Zhu, Shirui MaoAbstractLow drug loading efficiency is one of the main obstacles hindering the application of contact lenses (CLs) as the carrier for extended ocular drug delivery. Here in this study, a simple and effective drug loading method based on salt induced modulation was proposed and demonstrated with mechanism elucidation. First of all, using poly (2-hydroxyethyl methacrylate) (p-HEMA) as the contact lens material, betaxolol hydrochloride, diclofenac sodium and betaxolol base as the model drugs with diffe...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Optimization of taste-masking on ibuprofen microspheres with selected structure features
Publication date: Available online 9 June 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Wei Qin, Yuanzhi He, Zhen Guo, Liu Zhang, Li Wu, Xianzhen Yin, Shailendra Shakya, Abi Maharjan, Yan Tang, Weifeng Zhu, Jiwen ZhangAbstractThe microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-coolin...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
