Preparation and characterization of nanoparticles from quaternized cyclodextrin-grafted chitosan associated with hyaluronic acid for cosmetics
Publication date: Available online 15 June 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sakhiran Sakulwech, Nattaya Lourith, Uracha Ruktanonchai, Mayuree KanlayavattanakulAbstractHyaluronic acid (HA, 20–50 kDa) is a hydrophilic macromolecule with anti-wrinkle effects and moisturizing properties. However, its high molecular weight prevents it from penetrating into the deeper layers of the skin and, thus, limits its benefits to topical effects. Thus, the objective of this study is to prepare nanoparticles of quaternized cyclodextrin-grafted chitosan (QCD-g-CS) associated with HA in different molar ratios ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Study of penetration mechanism of Labrasol on rabbit cornea by ussing chamber, RT-PCR assay, werstern blot and immunohistochemistry
This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Wes...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of micelles incorporated into thermosensitive hydrogels for intratumoral delivery and controlled release of docetaxel: A dual approach for in situ treatment of tumors
In conclusion, the DTX-MM-hydrogels prepared in this study have considerable potential as a drug delivery system, with higher tumor inhibition effects and are less toxic to normal tissues.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
Publication date: Available online 1 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xin Wang, Chang Li, Na Fan, Jing Li, Haotian Zhang, Lei Shang, Zhonggui He, Jin SunAbstractIn the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanopartic...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Welcome to this special issue of AJPS on Inhalation drug delivery
Publication date: Available online 8 September 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Philippe Rogueda, Hui Xin Ong, Oscar Liu, Darragh Murnane (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Antiurolithiatic activity of Alternanthera tenella Colla in ethylene glycol induced urolithiasis in rats
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sahithi Adepu, Raviraj Anand Devkar, Shilpee Chaudhary, Manganahalli Manjunath Setty (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Phytochemical investigation and antihyperglycemic activity of leaves of Aegle marmelos (L.) Correa
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Soe Sandar Phyo, Win Myint, Khine Khine Lwin, Aye Kyi, Myint Myint Than (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective action of Gmelina arborea (bark) and Punica granatum (peel) extracts
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Pai Vasudev, C.S. Shreedhara, K.S. Chandrashekar, D. Yamini (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Physiological and gene expressional alternation in obesity animal model for ADME/PK characterization
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sung-Hoon Ahn (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Determination of N-trans-feruloyltyramine content and nitric oxide inhibitory and antioxidant activities of Tinospora crispa
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Attawadee SaeYoon, Bhudsaban Sukkarn, Wichit Nosoongnoen, Chutima Jantarat, Poonsit Hiransai, Pajaree Sakdiset, Jiraporn Chingunpitak, Sunita Makchuchit, Arunporn Itharat (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Factors affecting formation of microemulsions containing modified coconut oil
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sirikarn Pengon, Chutima Limmatvapirat, Sontaya Limmatvapirat (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation and optimization of fenofibrate loaded self-microemulsifying drug delivery system (SMEDDS) by application of box-behnken design
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Jin Wook Tak, Bijay Kumar Poudel, Pathak Shiva, Toe Kyung Go, Kyu bong Woo, Dong Shik Kim, Han-Gon Choi, Jee-Heon Jeong, Chul Soon Yong, Jong Oh Kim (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Optimization of trans-resveratrol extraction from peanut kernels using supercritical fluid extraction
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Kritamorn Jitrangsri, Amornrut Chaidedgumjorn, Malai Satiraphan (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design
Publication date: Available online 13 October 2017Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Thuy Tran, Thomas Rades, Anette MüllertzAbstractThe development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs is usually based on traditional one-factor-at-a-time approaches. These approaches may be inadequate to analyse the effect of each excipient and their potential interactions on the emulsion droplet size formed when dispersing the SNEDDS in an aqueous environment. The current study investigates the emulsion droplet sizes formed from SNEDDS conta...
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Development and bioequivalence study of potassium chloride extended release tablets
Publication date: Available online 23 October 2017Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Thu Van Le Thi, Nghiem Le Quan, Hau LeAbstractThe purposes of this study are to prepare the generic extended release tablet of potassium chloride (PC) 600 mg and to compare the absorption of potassium ion from the experimental tablets to that of Kaleorid® LP 600 mg (Leo Pharmaceutical Products, Denmark). Carnauba wax was used as retardant in the matrix core tablets. The core tablets were coated with blends of ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) to modulate the drug release. Results of...
Source: Asian Journal of Pharmaceutical Sciences - July 5, 2018 Category: Drugs & Pharmacology Source Type: research