Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex

This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.Graphical AbstractFor improving the utilization of NK, a complex of NK-TUDCA to reduce the toxicity of intravenous NK injection, was designed by using NK as the cationic moiety and TUDCA as the anionic moiety. The NK-TUDCA reduced toxicity by the delayed release of NK from the complex and still possessed the inherent powerful efficiency of NK.
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research