Highlights from Gastro Update Europe – Prague, June 2018
Publication date: Available online 30 November 2018Source: Arab Journal of GastroenterologyAuthor(s): Guido N.J. Tytgat (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - December 1, 2018 Category: Gastroenterology Source Type: research
Characterization of PI3KCA and BRAF mutations in gastric adenocarcinoma: An approach to a personalized targeted therapy for Moroccan HER2 overexpressed patients
ConclusionThe association between HER2 expression and PI3KCA alteration in gastric adenocarcinoma is most probably necessary to identify trastuzumab responders. Consequently, the 83,64% rate of HER2-positive patients harboring wild-type mutations possibly represents the portion of patients responding to trastuzumab while the 16,36% rate of patients carrying at least one of the studied mutations represents the portion of potentially non responsive patients to the targeted therapy, and thus may be considered as good candidates for multi-drug targeted therapy. (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - November 29, 2018 Category: Gastroenterology Source Type: research
Managing diabetes and liver disease association
Publication date: Available online 9 November 2018Source: Arab Journal of GastroenterologyAuthor(s): Abd Elkhalek Hamed, Medhat Elsahar, Nadia M. Elwan, Sara Elnakib, Mervat Naguib, Hanan Hamed Soliman, Ashraf Ahmed Aboubakr, Amany AbdelMaqsod, Heba Sedrak, Samir N. Assaad, Reda Elwakil, Gamal Esmat, Samira Salh, Taymour Mostafa, Sherif Mogawer, Sameh Emil Sadek, Maha M. Saber, Hanan Ezelarab, Asem Ashraf Mahmoud, Souad SultanAbstractThere is strong association between liver diseases and diabetes (DM) which is higher than expected by a chance association of two very common disorders. It can be classified into three categor...
Source: Arab Journal of Gastroenterology - November 11, 2018 Category: Gastroenterology Source Type: research
Editorial Board
Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - October 13, 2018 Category: Gastroenterology Source Type: research
Retroperitoneal choriocarcinoma diagnosed by endoscopic ultrasonography-guided fine needle aspiration biopsy
Publication date: Available online 24 September 2018Source: Arab Journal of GastroenterologyAuthor(s): Hiroyuki Matsubayashi, Ryo Yamashita, Keiko Sasaki, Tomohiro Iwai, Hirotoshi Ishiwatari, Kenichiro Imai, Hiroyuki OnoAbstractA 25-year-old man, with a retroperitoneal bulky mass invading the posterior pancreas head, was referred to investigate and treat his rapidly advancing disease. An endoscopic ultrasonography guided-fine needle aspiration biopsy (EUS-FNAB), performed the next day, and followed by immunostaining for human chorionic gonadotropin (hCG), led to a histological diagnosis of choriocarcinoma. An elevated leve...
Source: Arab Journal of Gastroenterology - October 5, 2018 Category: Gastroenterology Source Type: research
Tomosynthesis for colonic localization of patency capsules
Publication date: Available online 24 September 2018Source: Arab Journal of GastroenterologyAuthor(s): Teppei Omori, Ayumi Ito, Shinichi Nakamura, Katsutoshi Tokushige (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - October 5, 2018 Category: Gastroenterology Source Type: research
Evaluation of interleukin 23 (IL-23) as a non-invasive test of disease severity in patients with ulcerative colitis
ConclusionOur findings confirm the suggestion that IL-23 level measurement may be of value as a non-invasive test in the diagnosis and disease severity assessment in patients with UC. (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - October 5, 2018 Category: Gastroenterology Source Type: research
Occult hepatitis C virus infection among haemodialysis patients
ConclusionThese results highlight the potential risk of hepatitis C virus transmission from patients within haemodialysis units in Egypt. Isolation of patients on dialysis machines depending on the results of hepatitis serological markers is not enough. Testing for hepatitis C virus -RNA in peripheral blood mononuclear cells is more reliable in identifying patients with an OCI when a liver biopsy is not available. (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - September 21, 2018 Category: Gastroenterology Source Type: research
Two novel SNPs in the promoter region of PKR gene in hepatitis C patients and their impact on disease outcome and response to treatment
ConclusionThis study is a pioneer clinical study on these two functional SNPs (rs62133148T>G and rs12992188 C>T). The rs62133148 polymorphism does not show any association with response to treatment. The TT genotype in rs12992188 polymorphism shows association with response to treatment. Therefore, patients with TT genotypes were more likely to achieve SVR. (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - September 21, 2018 Category: Gastroenterology Source Type: research
Expression of epidermal growth factor receptor (EGFR) in colorectal cancer: An immunohistochemical study
ConclusionsEGFR expression by immunohistochemistry in CRC is variably correlated with clinicopathological parameters. Its assessment by this method has still not proved its predictive value. (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - September 20, 2018 Category: Gastroenterology Source Type: research
Giant duodenal Brunner’s gland hamartoma successfully treated via endoscopic mucosal resection
We describe a patient with a giant Brunner’s gland hamartoma in the duodenum who was safely treated by endoscopic mucosal resection (EMR). A 64-year-old woman visited our hospital for a workup of severe anaemia (haemoglobin level: 5 g/dL). Oesophagogastroduodenoscopy revealed a large pedunculated and elongated polypoid lesion measuring approximately 70 mm in longitudinal diameter, located at the anterior wall of the duodenal bulb. We diagnosed her as having gastrointestinal bleeding originating from this lesion. Although we considered surgical intervention initially, en bloc EMR, a less invasive treatment, was finall...
Source: Arab Journal of Gastroenterology - September 20, 2018 Category: Gastroenterology Source Type: research
Editorial Board
Publication date: June 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 2Author(s): (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - July 12, 2018 Category: Gastroenterology Source Type: research
The effect of premedication with peppermint oil capsules (Colpermin) prior to colonoscopy: A double blind randomized placebo-controlled trial
ConclusionThis randomized controlled trial does not support the routine use of peppermint oil capsules prior to colonoscopy as a tool for procedure optimization, and patients’ and endoscopist’s satisfaction. (Source: Arab Journal of Gastroenterology)
Source: Arab Journal of Gastroenterology - July 10, 2018 Category: Gastroenterology Source Type: research
A difficult diagnosis of coeliac disease: Repeat duodenal histology increases diagnostic yield in patients with concomitant causes of villous atrophy
We report a case of a woman with anaemia, weight loss and diarrhoea with an initial diagnosis of seronegative CD and a histological documented villous atrophy who did not improve on gluten-free diet due to the concomitant presence of common variable immunodeficiency (CVID) and Giardia lamblia infection. This case report confirms that CD diagnosis in CVID patients is difficult; the combination of anti-endomysial antibodies (EmA-IgA), anti-tissue transglutaminase antibodies (tTG-IgAb) antibodies and total IgA is obligatory in basic diagnostic of CD but in CVID are negative. Furthermore, the typical histological aspects of th...
Source: Arab Journal of Gastroenterology - July 10, 2018 Category: Gastroenterology Source Type: research
Gastric submucosal haematoma caused by an amyloidoma in the setting of multiple myeloma
Publication date: December 2017Source: Arab Journal of Gastroenterology, Volume 18, Issue 4Author(s): Stella C. Pak, John-Phillip T. MarkovicAbstractThis is a case of a 67-year-old woman with a history of multiple myeloma with amyloidosis who presented with massive hematemesis. Emergent upper endoscopy revealed a mass on the greater curvature of the stomach, which measured approximately 3 cm in width and 7 cm in length. The patient underwent a wedge resection of the gastric mass without complication. Microscopic examination of the gastric mass revealed amorphous deposits that were congophilic in nature and stained posi...
Source: Arab Journal of Gastroenterology - July 10, 2018 Category: Gastroenterology Source Type: research
