An assessment of differences in costs and health benefits of serology and NAT screening of donations for blood transfusion in different Western countries
ConclusionThere are substantial differences in costs per QALY between countries for various HIV, HBV and HCV screening strategies. These differences are primarily caused by costs of screening tests and infection rates in the donor population. Within each country, similar cost per QALY results for serology and NAT compared to no screening, coupled with evidence of limited value of serology and NAT together prompts the need for further discussion on the acceptability of parallel testing by serology and NAT. (Source: Vox Sanguinis)
Source: Vox Sanguinis - June 1, 2017 Category: Hematology Authors: M. P. Janssen, M. Hulst, B. Custer, Tags: Original Paper Source Type: research
Prothrombin complex concentrate for emergent reversal of warfarin: an international survey of hospital protocols
For emergent warfarin reversal, four‐factor prothrombin complex concentrates (4FPCCs) are recommended by many international guidelines. We surveyed international clinical sites including members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Most sites have emergent warfarin reversal protocols (53% use PCC, 25% use PCC+ plasma and 2% use plasma alone); however, variation between adjusted dosing and fixed dosing was observed. (Source: Vox Sanguinis)
Source: Vox Sanguinis - June 1, 2017 Category: Hematology Authors: J. Gorlin, S. Kinney, M. K. Fung, A. Tinmouth, Tags: Short Report Source Type: research
Assessing the impact of perioperative blood transfusions on the survival of adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for appendiceal carcinomatosis
ConclusionsIn this retrospective study of adults who had undergone CRS‐HIPEC for appendiceal carcinomatosis, PBT was not significantly associated with survival. (Source: Vox Sanguinis)
Source: Vox Sanguinis - June 1, 2017 Category: Hematology Authors: P. Owusu ‐Agyemang, A. M. Zavala, U. U. Williams, A. Van Meter, J. Soliz, R. Kapoor, A. Shah, M. Hernandez, V. Gottumukkala, J. P. Cata Tags: Original Paper Source Type: research
Prehospital parameters can help to predict coagulopathy and massive transfusion in trauma patients
ConclusionsPrehospital parameters including the SI and resuscitation may help to better identify the severity of bleeding in trauma patients and the need for blood product administration at admission. (Source: Vox Sanguinis)
Source: Vox Sanguinis - June 1, 2017 Category: Hematology Authors: J. ‐S. David, E.‐J. Voiglio, E. Cesareo, O. Vassal, E. Decullier, P.‐Y. Gueugniaud, S. Peyrefitte, K. Tazarourte Tags: Original Paper Source Type: research
Development of RBC transfusion indications and the collection of patient ‐specific pre‐transfusion information
(Source: Vox Sanguinis)
Source: Vox Sanguinis - May 19, 2017 Category: Hematology Authors: M. H. Yazer, L. Watering, M. Lozano, Shreerang Sirdesai, Kylie Rushford, Erica M. Wood, Ana P. Yokoyama, Jose M. Kutner, Yulia Lin, Jeannie Callum, Christine Cserti ‐Gazdewich, Lani Lieberman, Jacob Pendergrast, Kate Pendry, Michael F. Murphy, Kathleen Tags: International Forum Source Type: research
Multiple red blood cell transfusions and iron overload in very low birthweight infants
ConclusionThere was a higher risk of iron overload in exposed infants in comparison with non‐exposed infants. Severe iron overload in VLBW infants may occur with a total transfusion volume >120 ml/kg. (Source: Vox Sanguinis)
Source: Vox Sanguinis - May 18, 2017 Category: Hematology Authors: J. D. Trevi ño‐Báez, E. Briones‐Lara, J. Alamillo‐Velázquez, M. I. Martínez‐Moreno Tags: Original Paper Source Type: research
Diary of Events
(Source: Vox Sanguinis)
Source: Vox Sanguinis - May 8, 2017 Category: Hematology Tags: Diary of Events Source Type: research
Issue Information
(Source: Vox Sanguinis)
Source: Vox Sanguinis - May 8, 2017 Category: Hematology Tags: Issue Information Source Type: research
Are there ethical differences between stopping and not starting blood safety measures?
ConclusionUnless stronger ethical objections can be found, blood system operators and regulators should be more willing to withdraw inefficient safety measures. (Source: Vox Sanguinis)
Source: Vox Sanguinis - May 2, 2017 Category: Hematology Authors: K. Kramer, M. F. Verweij, H. L. Zaaijer Tags: Original Paper Source Type: research
Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation
ConclusionOur results suggest that assaying T‐cell function before HSCT could determine individual risks for infectious complications and thus aid in clinical decision‐making regarding prophylactic and pre‐emptive anti‐infective therapy. (Source: Vox Sanguinis)
Source: Vox Sanguinis - May 2, 2017 Category: Hematology Authors: J. Nilsson, I. Granrot, J. Mattsson, B. Omazic, M. Uhlin, S. Thunberg Tags: Original Paper Source Type: research
Comparison of haemostatic function of PAS ‐C–platelets vs. plasma–platelets in reconstituted whole blood using impedance aggregometry and thromboelastography
ConclusionOur findings demonstrate that the function – aggregation and CD62P responsiveness – of PAS‐C–platelets in reconstituted whole blood is inferior to that of plasma–platelets, which may have implications in the setting of massive transfusions. (Source: Vox Sanguinis)
Source: Vox Sanguinis - May 1, 2017 Category: Hematology Authors: F. M. A. van Hout, I. J. Bontekoe, L. A. E. Laleijne, J. ‐L. Kerkhoffs, D. Korte, J. Eikenboom, J. G. Bom, P. F. Meer Tags: Original Paper Source Type: research
Autologous blood salvage in the era of patient blood management
Almost 150 years after the first autologous blood transfusion was reported, intraoperative blood salvage has become an important method of blood conservation. The primary goal of autologous transfusion is to reduce or avoid allogeneic red blood cell transfusion and the associated risks and costs. Autologous salvaged blood does not result in immunological challenge and its consequences, provides a higher quality red blood cell that has not been subjected to the adverse effects of blood storage, and can be more cost‐effective than allogeneic blood when used for carefully selected surgical patients. Cardiac, orthopaedic and...
Source: Vox Sanguinis - May 1, 2017 Category: Hematology Authors: R. A. Sikorski, N. A. Rizkalla, W. W. Yang, S. M. Frank Tags: Review Article Source Type: research
Oral antiplatelet therapy: impact for transfusion medicine
Patients on antiplatelet therapy, be it aspirin only, or aspirin in combination with oral adenosine diphosphate (ADP) receptor inhibitors like clopidogrel, prasugrel and ticagrelor, or the protease‐activated receptor‐1 inhibitor vorapaxar, may develop bleeding or need transient reversal of platelet blockade for acute interventions. In this review, we summarize reports on patients with antiplatelet therapy receiving platelet concentrates due to bleeding, and in vitro experiments estimating the feasibility to restore platelet function by spiking blood from healthy individuals or patients on antiplatelet treatment with no...
Source: Vox Sanguinis - May 1, 2017 Category: Hematology Authors: T. Gremmel, S. Panzer Tags: Review Article Source Type: research
Development of RBC transfusion indications and the collection of patient ‐specific pre‐transfusion information: summary
(Source: Vox Sanguinis)
Source: Vox Sanguinis - May 1, 2017 Category: Hematology Authors: M. H. Yazer, L. Watering, M. Lozano, S. Sirdesai, K. Rushford, E. M. Wood, A. P. Yokoyama, J. M. Kutner, Y. Lin, J. Callum, C. Cserti ‐Gazdewich, L. Lieberman, J. Pendergrast, K. Pendry, M. F. Murphy, K. Selleng, A. Greinacher, N. Marwaha, R. Sharma, A. Tags: International Forum Source Type: research
A prospective observational study on effects of fever on red cell transfusion outcome
The effects of fever on red cell transfusions are not well documented. In this pilot study, we have compared the outcome of red‐blood‐cell transfusions in haematologic patients with and without fever. The results indicate that haemoglobin increment per unit is significantly lower in febrile patients receiving red cell transfusions than in patients without fever. These findings are in line with earlier findings in preclinical studies. Larger studies are necessary to confirm our results, and laboratory studies should be conducted to investigate the underlying mechanisms. (Source: Vox Sanguinis)
Source: Vox Sanguinis - May 1, 2017 Category: Hematology Authors: Ø. Wendelbo, E. Netland Opheim, T. H. Felli Lunde, Ø. Bruserud, T. Hervig, H. Reikvam Tags: Short Report Source Type: research
