Anti ‐HCV immunoblot indeterminate results in blood donors: non‐specific reactivity or past exposure to HCV?
ConclusionThe results of this study indicate that PRISM ChLIA s/co ratios >2·00 with IB indeterminate results predict exposure to HCV, particularly in the presence of putative risk factors for HCV infection. These findings may be applied to optimizing counselling of donors with indeterminate HCV results. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 29, 2017 Category: Hematology Authors: P. Kiely, C. Styles Tags: Original Paper Source Type: research
Issue Information
(Source: Vox Sanguinis)
Source: Vox Sanguinis - August 29, 2017 Category: Hematology Tags: Issue Information Source Type: research
Hepatitis E virus RNA in Australian blood donors: prevalence and risk assessment
ConclusionHepatitis E virus viremia is rare in Australia and lower than the published RNA prevalence estimates of other developed countries. The risk of TT‐HEV adverse outcomes is negligible, and HEV RNA donor screening is not currently indicated. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 18, 2017 Category: Hematology Authors: V. C. Hoad, C. R. Seed, J. J. Fryk, R. Harley, R. L. P. Flower, B. M. Hogema, P. Kiely, H. M. Faddy Tags: Original Paper Source Type: research
The antioxidant capacity of erythrocyte concentrates is increased during the first week of storage and correlated with the uric acid level
ConclusionThe marked increase in AOP during the first week of storage suggests that RBCs are impacted early by the modification of their environment. The AOP behaviour reflects the changes in metabolism activity following the adjustment of the extracellular uric acid level. Knowing the origin, interdonor variability and the effects of the AOP on the RBCs could be beneficial for the storage quality, which will have to be further studied. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 18, 2017 Category: Hematology Authors: M. Bardyn, S. Maye, A. Lesch, J. Delobel, J. ‐D. Tissot, F. Cortés‐Salazar, P. Tacchini, N. Lion, H. H. Girault, M. Prudent Tags: Original Paper Source Type: research
Blood donor show behaviour after an invitation to donate: The influence of collection site factors
ConclusionIn addition to individual factors, collection site characteristics are important in explaining variation in donor show behaviour, thus presenting clues for blood bank policies and interventions to improve donor show. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 18, 2017 Category: Hematology Authors: E. ‐M. Merz, B. J. H. Zijlstra, W. L. A. M. Kort Tags: Original Paper Source Type: research
Prevention of transfusion ‐associated graft‐versus‐host disease with pathogen‐reduced platelets with amotosalen and ultraviolet A light: a review
ConclusionPathogen‐reduced platelets with amotosalen and UVA light can be used as a measure to prevent TA‐GVHD. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 18, 2017 Category: Hematology Authors: J. Cid Tags: Review Article Source Type: research
Evolution of MNC and lymphocyte collection settings employing different Spectra Optia ® Leukapheresis systems
ConclusionThe Spectra Optia® CMNC device using lower centrifugal force (PF4·0) showed similar target cell yield and composition as well as collection efficiencies with superior performance parameters and lower PLT contamination compared to the MNC setting. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 14, 2017 Category: Hematology Authors: M. Punzel, A. Kozlova, A. Quade, A. H. Schmidt, R. Smith Tags: Original Paper Source Type: research
Preceding haemorrhagic shock as a detrimental risk factor for respiratory distress after excessive allogeneic blood transfusion
ConclusionThe lung and the heart can tolerate volume overloads with HES, CR and even transfused blood. However, a preceding HS may induce an inflammatory response, making the lung vulnerable to subsequent blood overloads. In this study, a preceding haemorrhagic shock mediated respiratory distress following massive transfusion in a swine model. (247 words) (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: R. Masuda, T. Iijima, R. Kondo, Y. Itoda, M. Matsuhashi, S. Hashimoto, T. Kohira, N. Kobayashi, H. Okazaki Tags: Original Paper Source Type: research
Correlation between plasma fibrinogen and FIBTEM thromboelastometry during liver transplantation: a comprehensive assessment
ConclusionFIBTEM MCF is not a good indicator of plasma fibrinogen values after graft reperfusion. FIBTEM MCF >8 mm during the LT procedure is associated with less RBC transfusion. FIBTEM MCF values over 10 mm could lead to unnecessary fibrinogen administration. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: A. Blasi, A. Sabate, J. Beltran, M. Costa, R. Reyes, F. Torres Tags: Original Paper Source Type: research
Safety of leucodepleted salvaged blood in oncological surgery: an in vitro model
Intra‐operative blood cell salvage (IOCS) is mainly avoided in onco surgery due to the suspicion that it could increase metastasis’ risk. We simulated IOCS followed by leucodepletion: HCT116 (human colorectal cancer) cells were inoculated into packed red blood cells units, and their distribution was evaluated, step‐by‐step, by flow cytometry and immunohistochemistry. Most of HCT116 cells were lost during washing, and almost completely removed after filtration. IOCS plus leucodepletion could be of great advantage for oncological patients, where allogenic blood transfusion could influence tumour progression. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: C. Marraccini, L. Merolle, P. Berni, K. Boito, I. Tamagnini, E. Kuhn, M. Ragazzi, R. Baricchi, T. A. Pertinhez Tags: Short Report Source Type: research
Evaluation of droplet digital PCR for quantification of residual leucocytes in red blood cell concentrates
ConclusionDroplet digital PCR to enumerate leucocytes offers an alternative for quality control of leucoreduced blood products. Sensitivity, specificity and reproducibility are comparable to flow‐cytometry. The option to collect samples over an extended period of time and the automatization introduce attractive features for routine quality control. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: A. Doescher, U. Loges, E. K. Petershofen, T. H. M üller Tags: Original Paper Source Type: research
Agonist ‐induced platelet reactivity correlates with bleeding in haemato‐oncological patients
ConclusionAgonist‐induced platelet reactivity was significantly correlated to bleeding. Platelet function testing could provide a basis for a personalized transfusion regimen, in which platelet transfusions are limited to those at risk of bleeding. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: B. Batman, E. R. Bladel, M. Hamersveld, P. C. M. Pasker ‐de Jong, S. J. A. Korporaal, R. T. Urbanus, M. Roest, L. A. Boven, R. Fijnheer Tags: Original Paper Source Type: research
Enlargement of the WHO international repository for platelet transfusion ‐relevant bacteria reference strains
ConclusionThe WHO ECBS approved all bacterial strains (except M. morganiiPEI‐B‐P‐74 and S. choleraesuisPEI‐B‐P‐78) for repository enlargement. The strains were stable, suitable for spiking with low CFU numbers, and proliferation was independent of the PC donor. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: E. Spindler ‐Raffel, R. J. Benjamin, C. P. McDonald, S. Ramirez‐Arcos, K. Aplin, I. Bekeredjian‐Ding, D. Korte, C. Gabriel, B. Gathof, K.‐M. Hanschmann, K. Hourfar, C. Ingram, M. R. Jacobs, S. D. Keil, Y. Kou, B. Lambrecht, J. Marcelis, Z. Mukhtar Tags: Original Paper Source Type: research
Bacterial testing of platelets – has it prevented transfusion‐transmitted bacterial infections in Australia?
ConclusionBCS has been successful in detecting platelet units containing pathogenic bacteria. The incidence of TTBI from platelets has fallen since the introduction of BCS, but the risk has not been eliminated due to rare false‐negative results. In the absence of a pathogen inactivation system for red blood cells, BCS provides ‘surrogate’ testing of red blood cells from which platelets have been manufactured. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: J. Thyer, Z. Perkowska ‐Guse, S. L. Ismay, A. J. Keller, H. T. Chan, P. M. Dennington, B. Bell, G. Kotsiou, J. M. Pink Tags: Original Paper Source Type: research
Transfusion ‐related acute lung injury risk mitigation: an update
We describe the measures taken by blood collection facilities to reduce the risk of TRALI in the United States, Canada and European countries. We also review the literature for the effectiveness of these measures. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2017 Category: Hematology Authors: Z. K. Otrock, C. Liu, B. J. Grossman Tags: Review Article Source Type: research
