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Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs
ConclusionIn the setting of advanced disease, dacarbazine appears to have modest activity against HS and warrants further investigation. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 1, 2017 Category: Veterinary Research Authors: K. A. Kezer, L. G. Barber, S. H. Jennings Tags: ORIGINAL ARTICLE Source Type: research

The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma
ConclusionThe JAK2/STAT5 pathway is a novel potential target of therapy in canine mastocytoma. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 1, 2017 Category: Veterinary Research Authors: Alexandra Keller, Bettina Wingelhofer, Barbara Peter, Karin Bauer, Daniela Berger, Susanne Gamperl, Martin Reifinger, Sabine Cerny ‐Reiterer, Richard Moriggl, Michael Willmann, Peter Valent, Emir Hadzijusufovic Tags: ORIGINAL ARTICLE Source Type: research

Bosutinib, an SRC inhibitor, induces caspase ‐independent cell death associated with permeabilization of lysosomal membranes in melanoma cells
ConclusionOur data suggest that Bosu induces the cell death through induction of LMP in melanoma cells and is a promising therapeutic agent for treatment of melanoma in both dogs and humans. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 1, 2017 Category: Veterinary Research Authors: S. Noguchi, S. Shibutani, K. Fukushima, T. Mori, M. Igase, T. Mizuno Tags: ORIGINAL ARTICLE Source Type: research

Melatonin and IL ‐25 modulate apoptosis and angiogenesis mediators in metastatic (CF‐41) and non‐metastatic (CMT‐U229) canine mammary tumour cells
ConclusionThis is the first study evaluating the potential use of these strategies in CF‐41 and CMT‐U229 cell lines and together encourages subsequent in vitro and in vivo studies for further exploration of clinical applications. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - February 28, 2017 Category: Veterinary Research Authors: G. B. Gelaleti, T. F. Borin, L. B. Maschio ‐Signorini, M. G. Moschetta, E. Hellmén, A. M. Viloria‐Petit, D. A. P. C. Zuccari Tags: ORIGINAL ARTICLE Source Type: research

The use of low ‐dose metronomic chemotherapy in dogs—insight into a modern cancer field
This article reviews the rationale for treatment with MC, its mechanism of action and the main studies conducted in veterinary medicine, and discusses the key challenges yet to be solved. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - February 28, 2017 Category: Veterinary Research Authors: T. B. Gaspar, J. Henriques, L. Marconato, F. L. Queiroga Tags: REVIEW ARTICLE Source Type: research